LFA-1 signaling

T cell

T cell receptor

LFA-1

Ser 1140

intracellularsignaling

HLA

antigen

APCcell

TalinCalpainPtdIns(4,5)P2

TalinHead

LFA-1 signaling

LFA-1

Ser 1140

T cell

intracellularsignaling

T cell receptor

HLA

antigen

APCcell

LFA-1

increased affinity

for ICAM-1

PKC

LFA-1 signaling

Ser 1140

T cell

Thr 758

intracellularsignaling

T cell receptor

HLA

antigen

APCcell

increased affinity

for ICAM-1

14-3-3 ? GEFactin reorganization

LFA-1 signaling

LFA-1

Ser 1140

T cell

Thr 758

Rac1GDP

GTP Rac1LFA-1

clustering

intracellularsignaling

T cell receptor