Reproduced with permission of Palgrave Macmillan. This is taken from the author's original manuscript andhas not been reviewed or edited. The definitive, published version of this work can be found atwww.palgrave-journals.com. This article was published in the Geneva Papers on Risk and Insurance: Issuesand Practice.

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www.fda.gov/cder/drug/infopage/vioxx/vioxxgraham.pdf