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Global Emerging Fungal Infection Registry
Initiated in 2003
Report September 2012
Working group of the
Under the auspices of
Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer
Report September 2012 Page 2 of 34
Study Coordinators ........................................................................... 3
Introduction .................................................................................... 6
Current Results ............................................................................... 10
Achievements and Goals .................................................................. 17
Presentations 2012, 2011, 2010 ..................................................... 17
Publications ................................................................................. 18
Awards ........................................................................................ 18
Recent Accomplishments ............................................................... 18
2012 Goals .................................................................................. 19
Contact Information ......................................................................... 20
Participating Institutions................................................................... 21
Report September 2012 Page 3 of 34
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Austria
Elisabeth Presterl, MD Allgemeines Krankenhaus -Universitätskliniken Wien Währinger Gürtel 18-20 1090 Wien T +43-1-40400-4440 F +43-1-4400-4418 elisabeth.presterl@meduni wien.ac.at
Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str. 3 6020 Innsbruck T +43-512-9003-70725 F +43-512-9003-73700 cornelia.lass-floerl@uibk.ac.at
Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz 4 8010 Graz T +43-316-380-7719 F +43-316-380-9648 walter.buzina@meduni-graz.at
Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T +43-512-9003-71304 F +43-512-582-088 ulrich.strasser@i-med.ac.at
Brazil
Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky S/N 21941-590 Rio de Janeiro T +55-21-2562-2463 F +55-21-2562-2460 mnucci@hucff.ufrj.br
Czech Republic
Zdeněk Ráčil, MD Dept. of Internal Medicine University Hospital Brno Jihlavska 20, 62500 Brno T +420-53223-2830/3642 F +420-53223-3603 zracil@fnbrno.cz
Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska 20, 62500 Brno T +420 53223 2974 ikocmanova@fnbrno.cz
Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20, 62500 Brno T +420 53223 3642 mlengerova@nbrno.cz
Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska 20, 62500 Brno T +420 53223 1111 mmoulis@fnbrno.cz
Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska 20, 62500 Brno T. +420 53223 3073 lmalas@fnbrno.cz
Report September 2012 Page 4 of 34
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Germany
Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin 50924 Köln T +49-221-478-6494 F +49-221-478-3611 oliver.cornely@ctuc.de
Guido Fischer, MS, PhD Landesgesundheitsamt Baden-Württemberg Referat 96 - Arbeitsmedizin, umweltbezogener Gesundheitsschutz Nordbahnhofstraße 135 70191 Stuttgart T +49-711-904-39620 F +49-711-904-37105 guido.fischer@rps.bwl.de
Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg 25 24106 Kiel T +49-431-388-252 bialek@labor-krause.de
Carsten Müller, MD Klinikum der Universität Institut für Pharmakologie 50924 Köln T +49-221-478-5066 F +49 221 478 7184 c.mueller@uni-koeln.de
Axel Hamprecht, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr. 19-2 D-50935 Köln T +49-221-478 32023 F +49-(0)221-478-32134 axel.hamprecht@uk-koeln.de
India
Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, 600 116 T +91-944-523-9196 F +91 44 2476 5608 anupmalakra@yahoo.com
Report September 2012 Page 5 of 34
Study Coordinators
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Israel
Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St. 49100 Petah Tikva T +972-3-937-7377 F +972-3-937-6365 Moradv@clalit.org.il
Italy
Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito 1 00168 Roma T +39-6-355-03953 F +39-630-51343 lpagano@rm.unicatt.it
Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito 1 00168 Roma T +39-06-3015-4964 F +39-06-3051-152 msanguinetti@rm.unicatt.it
Annamaria Tortorano, MD Dip. Sanità Pubblica-Microbiologia-Virologia Milano Università di Milano Via Pascal, 36/38 20133 Milano T +39-2-503-15145 F +39-2-503-15146 annamaria.tortorano@unimi.it
Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, 6 50139 Firenze T +39-055-4271-286 F +39-055-4271-280 andrea.novelli@unifi.it
Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/38 20133 Milano T +39 0285994869 F +39 0285994800 Gianluca.vago@unimi.it
Turkey
Sevtap Arikan-Akdagli, MD Mycology Laboratory (Ankara) Hacettepe University 06100 Ankara F +90 (312) 3115250 sevtap.arikan@gmail.com
Report September 2012 Page 6 of 34
Introduction The incidence of invasive fungal infections (IFI) is increasing in all parts of the world. The etiology for this ongoing epidemiological development is not completely understood. However, major contributing factors are the increasing number of transplantation procedures undertaken around the world (estimated at 500,000 per year), a widening of the indications for intensive chemotherapy, and the growing number of other clinical conditions requiring immunosuppressive treatment.
Therapeutic standards have been developed for the most frequent IFI, i.e. candidiasis, aspergillosis and cryptococcosis. However, the so called “emerging fungi” are also a reason for the increased number of IFIs. Thus, clinicians are now facing infections due to a variety of different fungi without any reliable treatment recommendations and therapeutic decision making is not evidence based. Prevalence of “emerging fungi” is virtually unknown and there is an additional knowledge gap in pathogen biology, since isolates have not been collected systematically.
In order to overcome the lack of knowledge on epidemiology, clinical course, biology and pathomechanisms, and finally to develop an evidence based diagnostic-therapeutic integrated approach of IFI caused by “emerging fungi”, A Global Emerging Fungal Infection Registry – Fungiscope™ has been created.
Fungiscope™ uses a web-based electronic case form accessible via www.fungiscope.net. For inclusion into the registry patients require cultural, histopathological, serological or molecular evidence of IFI and the associated clinical symptoms and signs. The clinical data on underlying disorder and IFI will be collected and stored in an internet-based database. Additionally, the pathogen strains and samples of infected tissue are collected, examined and stored in a bio-bank – the Fungithek. The clinical and biological data are subsequently evaluated and analysed. Figure 1a and b present the data / sample flow and overall project structure. The clinical database and the bio-bank are connected and accessable to the public via a web-based search engine - FungiQuest (figure 2).
In the following report we introduce the most current results and achievements. We also discuss future goals and ongoing developments of the project.
Report September 2012 Page 7 of 34
Figure 1a: Project structure
Report September 2012 Page 8 of 34
Figure 1b: Material flow
Report September 2012 Page 9 of 34
Figure 2: FungiQuest database search engine
Report September 2012 Page 10 of 34
Current Results Until now, 299 cases have been documented and considered valid. The most frequently registered pathogens were Mucorales (previously termed Zygomycetes) (n=118; 39.5%), Fusarium spp. (n=51; 17.1%), yeasts (n=43; 14.4%), and Dematiaceae (n=34; 11.4%) followed by Penicillinum spp. / Paecilomyces spp. (n=15; 5.0%) and Scedosporium spp. (n=13; 4.3%) (figure 3). The majority of patients were Caucasian followed by Asian and North/South American Indian origins (figure 4). The contribution of cases by country is shown in figure 5.
Sites of infection differ among pathogens, see figure 6. In patients with invasive mucormycosis, the lungs were the most commonly involved organs with an incidence of 66.9%. Other involved sites were the paranasal sinuses (22.0%), deep soft tissues (13.6%) and the central nervous system (13.6%). Fusarium spp. infections most frequently presented as blood stream infections (51.0%) or skin infections (47.1%). Other commonly affected sites were lungs (35.3%) and deep soft tissues (21.6%). Infections with Dematiaceae mostly involved the eyes, paranasal sinuses, deep soft tissues, and skin (range from 11.8% - 32.4%). By contrast, yeasts were most often diagnosed from blood cultures (approximately 65%) followed by pulmonary infections (30.2%).
The evaluation of risk factors for the development of IFI revealed differences between individual pathogens shown in figure 7. The most common risk factors for developing an infection with Mucorales and Fusarium spp. were chemotherapy (approximately 54%) or haematopoetic stem cell transplantation (HSCT) (approximately 30%) followed by stay at an intensive care unit and diabetes mellitus, with rates of 13.7 – 18.6%.
Chemotherapy was also the most common risk factors in patients presenting with yeast infections (44.2%). In addition, 34.9% of patients were treated in intensive care units. Further risk factors were diabetes mellitus (14%) and solid organ transplantation (14%).
By contrast, patients with a Dematiaceae infection presented most frequently with diabetes mellitus (47.1%) and/or chronic renal disease (17.2%).
Mortality, attributable mortality and response to treatment differed among individual pathogens and are shown in figure 8. The highest overall mortality was observed in patients with mucormycosis (58.5%), followed by patients with yeast (53.5%) and Fusarium spp. infections (47.1%). In more than 70% of cases the cause of death was the fungal infection irrespective of causative species. By contrast, the lowest overall mortality was revealed in patients with Dematiaceae, equaling only 5.9%. None of these deaths was due to the fungal infection. The highest rates of complete and partial remissions were observed in patients with IFI caused by Dematiaceae and Penicillium/Paecilomyces spp (73%). Patients with a Mucorales infection displayed the lowest rate of response to treatment (44.9%).
In conclusion, the clinical relevance of invasive fungal infections by emerging fungi is increasing. In a short time, actual cases from several countries world-wide could be documented and showed a broad spectrum of pathogens. Further investigators and coordinators are encouraged to contribute to the success of Fungiscope™.
Report September 2012 Page 11 of 34
Figure 3: Distribution of 299 pathogens by major groups
Report September 2012 Page 12 of 34
Figure 4: Ethnicities
Report September 2012 Page 13 of 34
Figure 5: Case contributions by country
Report September 2012 Page 14 of 34
Figure 6: Risk factors for major groups
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Figure 7: Sites of infection for major groups
Report September 2012 Page 16 of 34
Figure 8: Outcomes for major groups
Report September 2012 Page 17 of 34
Achievements and Goals Presentations 2012, 2011 and 2010
October 19-23, 2012 Annual Congress of the German Society for Hematology and Oncology (DGHO), Stuttgart, Germany
September 9-12, 2012 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, USA
June 23-26, 2012 18th Congress of the International Society for Human and Animal Mycology, Berlin, Germany
April 25-28, 2012 11th Congress of Infectious Diseases and Tropical Medicine, Cologne, Germany
March 31-April 3, 2012 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), London, UK
January 24-25, 2012 3rd WATL-Congress, Berlin, Germany
October 2-5, 2011 5th Trends in Medical Mycology (TIMM), Valencia, Spain
September 30-Oct. 4, 2011 Annual Congress of the German Society for Hematology and Oncology (DGHO), Basel, Switzerland
September 17-21, 2011 51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, USA
September 1-3, 2011 45th Congress of the German Society for Mycology (DMykG e.V.), Kiel, Germany
May 7-10, 2011 21st ECCMID/27th ICC, Joint Congress of the European Society of Clinical Microbiology and Infectious Diseases and the International Society of Chemotherapy20th, Milan, Italy
March 31-April 2, 2011 Annual Congress of the German Society for Infectious Diseases (DGI), Leipzig, Germany
October 1-5, 2010 Annual Congress of the German Society for Hematology and Oncology (DGHO), Berlin, Germany
September 12-15, 2010 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), MA, Boston, USA
September 9-11, 2010 44th Congress of the German Society for Mycology (DMykG e.V.), Vienna, Austria
June 23-26, 2010 10th Congress of Infectious Diseases and Tropical Medicine, Cologne, Germany
June 18-19, 2010 MSD Workshop „Infektionen in der Hämatologie“, Munich, Germany
May 7-8, 2010 Paul-Ehrlich-Gesellschaft für Chemotherapie e.V., Spring Meeting of the “Sektion Antimykotische Chemotherapie”, Bonn, Germany
April 10-13, 2010 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Vienna, Austria
Report September 2012 Page 18 of 34
Publications
August 2012 Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ.Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia. Mycoses 2012, Aug 13. Doi: 10.1111/j.1439-0507.2012.02231.x. Epub ahead of print
October 2011 de Hoog GS, Robert V, Lackner M, Vehreschild MJ, Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia-Hermoso D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, Buzina W, Cornely OA, Guarro J, Cano J, Horré R Making moulds meet. Information retrieval as a basis for understanding Pseudallescheria and Scedosporium Mycoses. 2011 Oct;54 Suppl 3:1-4
December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V. Rickerts, C. Lass-Flörl, C. Beisel, R. Herbrecht, Y. Roth, G. Silling, A.J. Ullmann, K. Borchert, G. Egerer, J. Maertens, G. Maschmeyer, A. Simon, M. Wattad, G. Fischer, J.J. Vehreschild, O.A. Cornely Forty-one Recent Cases of Invasive Zygomycosis from a Global Clinical Registry J Antimicrob Chemother. 2010 Feb;65(2):296-302
July 2008 Rüping M.J.G.T., Albermann N., Ebinger F., Burckhard I., Beisel C., Müller C., Vehreschild J.J., Kochanek M., Fätkenheuer G., Bangard C., Ullmann A.J., Herr W., Kolbe K., Hallek M., Cornely O.A. Posaconazole concentrations in the central nervous system. J Antimicrob Chemother 2008 Dec;62 (6):1468-70
Awards
Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology (DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on Fungiscope
Recent Accomplishments
Initiation of the MSG Phaeohyphomycosis Registry by use of the Fungiscope database in October 2012.
Abstract on the Fusarium spp. Infections joint analysis in cooperation with the Brazilian Fusarium spp. Group (Prof. Marcio Nucci, Rio de Janeiro, Brazil) presented as an oral presentation at the ICAAC 2012. Manuscript in preparation.
Newly established cooperation with the Robert Koch Institute in (Dr. Volker Rickerts, Berlin, Germany) for extended diagnostics on paraffin embedded specimens of patients
Report September 2012 Page 19 of 34
with suspected emerging invasive fungal infections by use of sequencing plus ribosomal RNA FISH
Initiation of an analysis of combination treatment with liposomal Amphotericin B plus posaconazole for mucormycosis infections in co-operation with the SEIFEM study group (Prof. Livio Pagano, Rome, Italy)
Agreement with the ECMM signed to use the Fungiscope clinical database for conducting the ECMM TriReg Study on Trichosporon spp. infections
Database restructuring including:
o Re-evaluation of all cases with respect to infection vs. colonization
o Harmonizing different wording used for documentation
o Structural adjustments facilitating data export and analysis
Initiation of an epidemiological online survey to monitor trends
2012 Goals
Publication of a subset analysis on rare yeasts, including resistance patterns
Publication of a comparison between sequencing and morphological results for the first 100 Fungiscope isolates
Extending the FungiQuest™ platform (online since April 2010):
o Faster inclusion of new cases
o Inclusion of FungiThek / isolate information
o Improved search-engine
Report September 2012 Page 20 of 34
Contact Information
Chair:
Oliver A. Cornely, MD, FIDSA, FACP
oliver.cornely@ctuc.de
Coordinating Physicians:
Maria J.G.T. Vehreschild (née Rüping), MD
maria.vehreschild@ctuc.de
Kerstin Wahlers, MD
kerstin.wahlers@ctuc.de
Technical advisor, site operator clinicalsurveys.net:
Jörg J. Vehreschild, MD
janne.vehreschild@ctuc.de
Uniklinik Köln
Infectious Diseases – Clinical Trials Unit II
BH E15 R64
Kerpener Strasse 62
50937 Köln
Germany
T +49-221-478-6494
F +49-221-478-3611
www.fungiscope.net
Report September 2012 Page 21 of 34
Participating Institutions
Argentina
El Centro de Internación de FUNDALEU, Departamento Medico, Buenos Aires, Argentina Maria Cecilia Dignani
Instituto Nacional de Enfermedades Infecciosas "Dr. C. G. Malbrán", Buenos Aires, Argentina Susana Cordoba
Centro de Referencia de Micología Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
Marisa Biasoli
Centro de Trasplante de Médula Ósea de Rosario (CETRAMOR), Rosario, Argentina. José Anibal Cozzi
Australia
Department of Microbiology & Infectious Diseases, Royal Perth Hospital, Perth, Australia Christopher Heath
Austria
Abt. f. Anästhesie und Intensivmedizin, Wilhelminenspital Wien, Wien, Austria Peter Wimmer
Anästhesiologie und Intensivmedizin, Landesklinikum Thermenregion Baden, Baden, Austria Franz Schwameis
Infektionen und Tropenmedizin, Universitätsklinik I für Innere Medizin, Medizinische Universität Wien, Wien, Austria
Christina Kratzer, Elisabeth Presterl
Institut für Anästhesie und Intensivmedizin, Landeskrankenhaus Steyr, Steyr, Austria Achim von Goedecke
Institut für Hygiene, klinische Bakteriologie und Mykologie, Medizinische Universität Graz, Graz, Austria
Walter Buzina
Institut für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria
Cornelia Lass-Flörl, Anna Huppert, Isabella Schalk
Institut für Pathologie, Medizinische Universität Innsbruck, Innsbruck, Austria Ulrich Strasser
Kinder- Herzzentrum Linz, Allgemeines Krankenhaus Linz, Linz, Austria Werner Moosbauer
Klinik für Anästhesiologie, Wagner-Jauregg Nervenklinik, Linz, Austria Udo Illievich
Klinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Austria Sebastian Ott
Report September 2012 Page 22 of 34
Krankenhaushygiene, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria Ulrich Zerlauth
Section of Infectious Diseases, Department of Medicine, Medical University of Graz, Austria Martin Hoenigl
Universitätsinstitut für Medizinische Mikrobiologie, Hygiene und Infektiologie - SALK Labor GmbH, Salzberger Universitätsklinikum, Salzberg, Austria
Markus Hell
Universitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Austria Katharina Pfistershammer
Belgium
University Hospital Gasthuisberg , Leuven, Belgium Katrien Lagrou, Johan, Maertens, Isabel Spriet
Brazil
Hematology and Mycology Laboratory, Hospital Universitário Clementino Fraga, UFRJ, Rio de Janeiro, Brazil
Marcio Nucci
Infection Control Dept., Santa Casa Complexo Hospitalar, Universidade Federal do Rio Grande do Sul, Brazil
Alessandro Pasqualotto
Laboratory of Mycology, Hospital das Clinicas, Federal University of Paraná, Curitiba, Brazil Flávio de Queiroz Telles
Serviço de Oncohematologia / TMO, Hospital Univ. Prof. Edgard Santos - UFBA, Salvador, Bahia, Brazil
Marco Aurélio Salvino, Monica Botura
Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Denise Pereira
Canada
Department of Medicine, Peter Lougheed Center, Calgary, Canada Andrew Johnson
Departments of Medicine & Microbiology and Immunology, McGill University, Montreal, Canada
Don Sheppard
Microbiology and Infectious Diseases, SMBD - Jewish General Hospital, Montreal, Canada Mark Miller
Service de Maladies Infectieuses, Département de Pédiatrie, McGill University, Montreal, Canada
Philipe Ovetchkine
Laboratoire de santé publique du Quebec, Secteur Mycologie, Sainte-Anne-de Bellevue Philippe Dufresne
Report September 2012 Page 23 of 34
(Quebec), Canada
Chile
Facultad de Medicina, Universidad de Valparaíso, Chile Thomas Weitzel
Unidad de Infectología, Clínica Alemana, Santiago de Chile, Chile Luis Thompson
China
Changhai Hospital, Department of Hematology, Shanghai P.R., China Jian-Min Yang
Institute of Hematology, Peking University People's Hospital, Beijing, China Feng-Rong Wang
Department of Hematology, Guangdong General Hospital, Guangdong, China Xin Du
Zhejiang University, School of Medicine, The First Affiliated Hospital, Bone Marrow Transplant Center, Hangzhou Zeijiang, China
He Huang
Columbia
Conjunto Residencial Montevideo, Medellin, Columbia Angela Restrepo, Angela Tobón
Croatia
Division of Haematology, Zagreb University Hospital Centre, Zagreb, Croatia Nemet Damir, Vrohvac Radovan
Cuba
Instituto de Hematologia e Imunologia, Habana, Cuba Alberto Arencibia Núñez
Czech Republic
Dept. of Internal Medicine, Hematology/Oncology, Faculty Hospital Brno, Brno, Czech Republic
Zdenek Racil
Dept. of Microbiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic Petr Hamal
Denmark
Dept. of Hematology, Copenhagen University Hospital, Copenhagen, Denmark Jannik Helweg-Larsen, Emil
Report September 2012 Page 24 of 34
Hermansen
France
Département d'Hématologie, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, and Université Denis Diderot, Paris, France
Emmanuel Raffoux, Patricia Ribaud
Hematology and Oncology, University Hospital of Strasbourg Hautepierre Hospital, Strasbourg, France
Raoul Herbrecht
Germany
Abteilung für Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Heidelberg, Germany
Johann Wilhelm Schier
Abteilung für Innere Medizin, Hämatologie u.Onkologie, Klinikum Frankfurt, Germany Michael Kiehl
Abteilung für Kinder- und Jugendmedizin, Marienhospital Witten, Witten, Germany Bahman Gharavi
Department of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität München, Muenchen, Germany
Thomas Loescher
Dermatologie, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Gesina Hansel
Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, Germany
Christoph Lange
Gastroenterologie & Infektiologie, St. Josef Hospital, Klinikum der Ruhr-Universität Bochum, Bochum, Germany
Renate Schlottmann
Abt. Hämatologie und Onkologie, Georg-August-Universität, Goettingen, Germany Silke Neumann
Hämatologie / Internist. Onkologie, Uniklinik Erlangen, Erlangen, Germany Wolf Rösler
Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam, Germany Angelika Gerhardt, Georg Maschmeyer
Hämatologie und Onkologie, Medizinische Klinik I, Kliniken Sindelfingen, Sindelfingen, Germany
Stefan Neuburger
Hämatologie und Onkologie, Universitätsklinikum Freiburg, Freiburg, Germany Hartmut Bertz, Werner C. Neubauer
Hämatologie/Onkologie/Immunologie/Rheumatologie, Klinikum Schwäbisch Gmünd, Holger Hebart
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Stauferklinik, Mutlangen, Germany
HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany Katrin Gollner, Kathrin Scheckenbach
II. Medizinische Klinik, Einheit für Stammzelltransplantation, Klinikum Augsburg, Augsburg Christoph Schmid
III. Medizinische Klinik, Universitätsklinikum Mannheim , Mannheim, Germany Dieter Buchheidt, Anne Dietz
Infektiologikum Frankfurt, Frankfurt, Deutschland Gaby Knecht
Institut für Infektiologie, Asklepios Klinik St. Georg, Hamburg, Germany M. Sabranski
Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck, Lübeck, Germany Jan Rupp
Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, Deutschland
Uwe Groß
Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany Claudia Wickenhauser
Institut für Tropenmedizin, Universitätsklinikum Düsseldorf, Düsseldorf, Germany Stefan Reuter
Interdisziplinäres Zentrum für Palliativmedizin, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany
Sabine Mousset
Kinderkardiologie und Pädiatrische Intensivmedizin, Klinikum der Universität München-Großhadern, München, Germany
Markus Loeff
Klinik III für Innere Medizin, Uniklinik Ulm, Ulm, Germany Georg Härter
Klinik f. Hämato-Onkologie, Klinikum Harlaching, Städtisches Klinikum München GmbH, München, Germany
Meinolf Karthaus, Xavier Schiel
Klinik für Anaesthesiologie und Operative Intensivmedizin, Klinikum Konstanz, Konstanz, Germany
Wolfgang Krüger
Klinik für Dermatologie, University of Tübingen, Tübingen, Germany Sybille Schmidt, Martin Schaller
Klinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München-Großhadern, München, Germany
Robert Guerkov
Klinik für Hämatologie und Onkologie, Vivantes Krankenhaus, Berlin, Germany Jörg Beyer, Markus Müller
Report September 2012 Page 26 of 34
Klinik für Hämatologie, Onkologie & Palliativmedizin, Städt. Kliniken Bielefeld gem.GmbH, Bielefeld, Germany
Martin Görner
Klinik für Hämatologie, Onkologie und Klin. Immunologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Thomas Schröder
Klinik für Hämatologie/Internistische Onkologie und Stammzelltransplantation, Kliniken Essen Süd, Essen, Germany
Mohammed Wattad
Klinik für Infektiologie und Tropenmedizin, LMU, München, Germany Thomas Loescher
Klinik für Innere Medizin IV, Onkologie und Hämatologie, Martin-Luther-University Halle-Wittenberg, Halle, Germany
Maximilian Christopeit, Hans-Heinrich Wolf
Klinik für Knochenmarktransplantation, Universitätsklinikum Essen, Essen, Germany Rudolf Trenschel
Klinik für Neonatologie, Universität zu Bonn, Bonn, Germany Cornelia Graef
Klinik für Nephrologie, Universitätsklinikum Essen, Essen, Germany Oliver Witzke
Klinik für Neurochirurgie, Charité-Universitätsmedizin Berlin, Berlin, Germany Olaf Süss
Klinik für Neurologie, Helios-Klinikum Berlin-Buch, Berlin, Germany Franz-Josef Dieste
Klinik für Innere Medizin II, Sektion Infektiologie, Universitätsklinikum Jena, Jena, Germany Matthias Pletz
Klinik I für Innere Medizin, Uniklinik Köln, Köln, Germany
Oliver Cornely, Fedja Farowski, Maria Vehreschild, Jörg Janne Vehreschild, Kerstin Wahlers
Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie - Transplantationszentrum Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
William Krüger,
Katrin Schulz
Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie und Onkologie, Universitätsklinikum Rostock, Rostock, Germany
Kersten Borchert, Lena Diestel, Michael Schmitt
Klinik und Poliklinik für Orthopädie, Uniklinik Köln, Köln, Germany Rolf Sobottke
Klinik und Poliklinik für Kinderheilkunde – Pädiatrische Hämatologie/Onkologie - Uniklinik Münster, Münster, Germany
Andreas Groll Jörg Ritter
Report September 2012 Page 27 of 34
Klinikum Dortmund Nord, Abteilung Pneumologie/Infektiologie, Dortmund, Germany Bernhard Schaaf, Stefanie Später, Greta Ullrich
Klinikum Neuperlach, Medizinische Klinik IV, München, Germany Meinolf Karthaus
Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, Uniklinik Erlangen, Erlangen, Germany
Stefan Kallert, Stefan Krause
Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, University of Witten/Herdecke, Köln, Germany
Stefan Sauerland
Medizinische Klinik A, KMT-Zentrum, Uniklinik Münster, Münster, Germany Gerda Silling
Medizinische Klinik I, Klinikum Bremen-Mitte, Bremen, Germany Henrike Thomssen
Medizinische Klinik III, Klinikum der Universität München-Großhadern, München, Germany Helmut Ostermann Lisa Peterson
Medizinische Klinik und Poliklinik I, Uniklinik Dresden, Dresden, Germany Ulrich Schuler
Medizinische Klinik und Poliklinik II, Charité-Universitätsmedizin Berlin, Berlin, Germany Markus Ruhnke
Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany
Werner Heinz, Jürgen Löffler, Hartwig Klinker, Bhanu Sinha, Andrew Ullmann
Medizinische Klinik und Poliklinik II, Universitätsklinikum Schleswig-Holstein, Kiel, Germany Heinz-A. Horst
Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany Gerlinde Egerer
Medizinische Poliklinik, Klinikum der Universität München-Großhadern, Müuenchen, Germany
Johannes Bogner
MVZ Labor Dr. Krause und Kollegen, Kiel, Germany Ralf Bialek
Mykologisches Labor, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Irina Vennewald
Onkologikum Frankfurt, Frankfurt, Germany Angelika Böhme
Pädiatrische Hämatologie und Onkologie Infektiologie, Zentrum der Kinderheilkunde, Universität zu Bonn, Bonn, Germany
Arne Simon
Rheumatologische Ambulanz, Sana Rheumazentrum Rheinland-Pfalz AG, Bad Kreuznach, Deutschland
Eckhard Weber
Report September 2012 Page 28 of 34
Robert Koch Institut, Abteilung für Infektionskrankheiten,Berlin, Germany Volker Rickerts
Universitätsklinikum Freiburg, Freiburg, Germany Helmut Lang
Zentrum für Infektiologie und Reisemedizin, Universitätsklinikum Freiburg, Freiburg, Germany
Dirk Wagner
Zentrum für Kinder- und Jugendmedizin, Klinik III, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany
Thomas Lehrnbecher
Institut für Hygiene, Kliniken der Stadt Köln, Krankenhaus Merheim, Köln, Germany Frauke Mattner
Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen, Essen, Germany Jörg Steinmann
Greece
1st Department of Propaedeutic Medicine, Athens University, Athens, Greece Anna Skiada
Cystic Fibrosis Department, Aghia Sophia Children´s Hospital, Athens, Greece Stavros Doudounakis
Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory, Athens University, Athens, Greece
George L. Petrikkos
Laboratory for Clinical Microbiology, Attikon University General Hospital, Athens, Greece Joseph Meletiadis
Hungary
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
Lorant Hatvani
India
Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Arunaloke Chakrabarti
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Ritesh Agarwal
Dept. of Microbiology, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Manipal, India
Prakash Yegneswaran
Indonesia
Department of Internal Medicine University of Indonesia, Faculty of Medicine University of Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia
Erni J Nelwan
Report September 2012 Page 29 of 34
Ireland
Dept. of Bacteriology, Belfast City Hospital, Belfast, Ireland John E. Moore
Trinity College, Dublin Saint James Hospital, Dublin, Ireland Thomas Rogers
Israel
Department of Otolaryngology – Head & Neck Surgery, Edith Wolfson Medical Center, Holon, Israel
Yehudah Roth
Hadassah University Medical Center, Jerusalem, Israel Maya Korem
Infectious Diseases Unit, Rabin Medical Center, Petah Tikva, Israel Morad Wattad
Sheba Medical Center Israel, Tel Aviv, Israel Nathan Keller
Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Ronen Ben-Ami
Italy
Department of Biomedical Science and Human Oncology — Hygiene Section, University of Bari, Bari, Italy
Maria Teresa Montagna
Dipartimento di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy Livio Pagano
Dipartimento di Farmacologia, Università degli Studi di Firenze, Firenze, Italy Andrea Novelli
Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Genova, Italy Andrea Bacigalupo
Hematology Unit, San Camillo-Forlanini Hospital, Rome, Italy Mariagrazia Garzia
Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy Maurizio Sanguinetti
Laboratorio di Micologia Medica, Sezione Sanità Pubblica, University of Milan, Milan, Italy Annamaria Tortorano
Oncoematologia Pediatrica, Policlinico G.B. Rossi, Verona, ItalyClinica di Oncoematologia Pediatrica, Azienda Ospedaliera Padova, Padova, Italy
Simone Cesaro
Pathology Unit, Luigi Sacco Hospital, University of Milan, Milan, Italy Gianluigi Vago
Japan
Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan
Katsuhiko Kamei, Akira Watanabe
Report September 2012 Page 30 of 34
Nagasaki University Hospital, Nagasaki, Japan Shigeru Kohno
Seirei Hamamatsu General Hospital, Shizuoka, Japan Shinichiro Morioka
Korea
Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea Joon Seong Park
Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation Center, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Korea
Hyeon Seok Eom
Kuwait
Microbiology Department, Health Sciences Center, Kuwait, Kuwait Eiman Mokaddas
Lebanon
American University of Beirut Medical Center, Beirut, Lebanon Souha Kanj-Sharara
Lithuania
Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Marius Miglinas
Vilnius University Hospital, Department of Hematology, Vilnius, Lithuania Indre Klimiene
Mexico
Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico, Eduardo Rodriguez-Noriega
Hospital General de Culiacán, Sinaloa, Mexico Ramón Rivas Llamas
IXtlamatia Clinical Research S.A. de C.V, Mexico City, Mexico Miguel Ángel Reséndiz
Netherlands
Department of Medical Microbiology, Canisius-Wilhelmina Hospital, Nijmegen, Netherlands Jacques Meis
University Medical Center Groningen, Groningen, the Netherlands Jan P. Arends
Peru
Hematology/ BMT Department, Rebagliati National Hospital, Lima, Peru Eduardo Fernandez-Vertiz
Report September 2012 Page 31 of 34
Portugal
Coimbra University Hospital, Coimbra, Portugal Rui Tome
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Rita Caramalho
Romania
Department of Mycology-Mycotoxicology, Universitatea Petre Andrei, Iasi, Romania Mihai Mares
Russia
Department of Clinical Mycology, Allergology and Immunology, St. Petersburg Medical Academy of Postgraduate Education, St. Petersburg, Russia
Nikolay Klimko Sofya Khostelidi
Singapore
Infectious Diseases Care, 03-01 Mount Elizabeth Medical Centre, 228510 Singapore Asok Kurup
National University Health System, University Medicine Center, Division of Infectious Diseases, NUHS Tower Block, Level 10, 119228 Singapore
Chai Louis Yin Ann
National University Health System, University Children\'s Medical Institute, Department of Pediatrics, 119228 Singapore, Singapore
Si Min Chan
Slovakia
National Cancer Institute, Bratislava, Slovakia Lubos Drgona
South Africa
Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Robert Dunn
Nelson R. Mandela School of Medicine, Pretoria, South Africa Teke Apalata
Spain
Department of Hematology, University Hospital La Fe, Valencia, Spain, Valencia, Spain Rebeca Rodriguez Veiga
Grupo Andaluz de Leucemias Agudas GALA, Hospital Juan Ramón Jiménez-Huelva, Huelva, Spain
Eusebio Martín Chacón
Servicio de Hematología de la Unidad de Consejo y Cuidado Oncológico de Sanitas, Hospital de la Princesa, Madrid, Spain
Rafael de la Cámara
Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla, Spain Martin-Pena
Report September 2012 Page 32 of 34
Almudena
Sweden
Clinical Micrbiological Laboratory, Sunderby Hospital, Luleå, Luleå, Sweden Peter Cettner
Switzerland
Abt. für Spitalhygiene und Spitalepidemiologie, Universitätsspital Basel, Basel, Switzerland Andreas Widmer
Division of Infectious Dieseases & Hospital Epidemiology, Universitätsspital Basel, Basel, Switzerland
U. Flueckiger
Medizin I Abteilung für Hämatologie, Universitätsspital Basel, Basel, Switzerland Alois Gratwohl
Institut für Infektionskrankheiten, Bern, Switzerland Stefan Zimmerli
Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Switzerland Sebastian Ott
University Hospital Lausanne (CHUV), Lausanne, Switzerland Andrej Trampiz
Taiwan
Far Eastern Memorial Hospital, Taipei, Taiwan Chiaying Liu
Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipeh, Taiwan Jih-Luh Tang
Division of Infectious Diseases, Department of Internal Medicine, Center For Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Yee-Chun Chen
Thailand
Division of Infectious Diseases and Tropical Medicine, Khon Kaen University, Khon Kaen, Thailand
Ploenchan Chetchotisakd
Turkey
Akdeniz University Medical Faculty, Department of Clinical Microbiology, Antalya, Turkey Dilara Ogunc
Department of Medicine, Section of Infectious Diseases, Hacettepe University Medical School, Ankara, Turkey
Murat Akova, Sevtap Arikan, Omrun Uzun
Division of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey Fatih Demirkan
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey
Can Boga
Report September 2012 Page 33 of 34
Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Serhat Imamoglu
Dokuz Eylul University Hospital, Department of Hematology, Izmir, Turkey Omur Gokmen Sevindik
United Kingdom
Department of Infection, St George's University of London, London, United Kingdom Jon Lambourne
NPHS Microbiology ABM (Swansea and Bridgend), Wales, United Kingdom Nidhika Berry
Princess Royal University Hospital, South London Healthcare NHS Trust, Farnborough Common, Orpington, Kent, United Kingdom
M. Mansour Ceesay
Southern General Hospital, Glasgow, United Kingdom Nitish Khanna
USA
Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine Institute and Transplant Center, Cleveland Clinic Lerner College of Medicine of Case Western University, Cleveland, Ohio, USA
Sherif Beniameen Mossad
Department of Pathology, University of Colorado, Denver, USA Diane Hutchinson
Division of Infectious Diseases, University of Washington Office, Washington, USA Philip Coffin
University of Alabama at Birmingham, Birmingham, USA John Baddley
University of Texas Southwestern Medical Center at Dallas, Dallas, USA Sanjay Revankar
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA
Linda Boyken
MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana, USA Patricia Connolly
Division of Medical Microbiology, Department of Pathology The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Sean Zhang
Report September 2012 Page 34 of 34