GFS Chemicals, Inc.Innovation and Commercialization through Chemistry ISO 9001:2008 Certified

• Supporting Major Industry Around the Globe• Flexible Production Capabilities for over 80 years• Batch Manufacturing for R&D through Commercialization• Organic and Inorganic Manufacturing Expertise• Semi-Custom Chemistry to Meet Customer Specifications• Problem Solving Chemists Complement Your Project Team• Manufacturing High Quality Chemicals up to metric tons• Exceedingly Responsive to Customer Inquiries• Achieving Accurate and Reliable Production Deadlines

GFS Corporate Story

Industries Served

• Environmental• Semiconductor• Pharmaceutical• Flavor & Fragrance• Superconductivity• Petrochemical• Agricultural• Automotive• Defense • Biotechnology• Power and Energy (Fuel

Cells, Batteries, etc)

Industries Served

• Electronics• Chemicals• Aerospace• Polymers• Coatings• Catalysts• Optics• Contract Manufacturing• Water treatment and

Analysis• Beverage/Dairy• Quality Control Laboratories

Innovation and Growth1928 1940’s 1960’s 1970’s 1980’s

Founded, Columbus Ohio. Perchlorate salts defined early business

Development of trace metal acids (ppt grade acid)

Rare Earth products introduced (CAN) Development of heteroaromatic ligands

Acquisition of Karl Fischer product line

Collaboration on first chrome etchants

Innovation and Growth

Heavy acquisition period includes quaternary salts, sodium biphenyl & Farchan acetylenics

Perchloric acid plant built($2.5M US)

ISO 9000 certification

Aquisition of APS Analytical Standards for turbidimeters, colorimeters and spectrophotomers

New organic production facility built ($3.5M US)

1990’s 1997 1997 2001 2003

Innovation and Growth

Perchloric Acid expansionInorganic and Organic research labs built

UDRI Chrome IV Replacement Project

Beta Phase Tri-Calcium Phosphate - Artificial Bone Scaffold

Purchase of Catalog Distribution Center, Private Labelling Operation and Laboratory Reagents Manufacturing

SOCMA Chem Steward Tier II Certification Ammonia Borane Manufacturing Partnership

2004 2007 2008 2009 2010

Safety and Environment

• GFS is a Tier II Chem Stewards organization focused on safety improvement practices and waste minimization, recovery policies and controls

• Selected Employees are DOT, IATA and IMO certified to support all modes of material logistics to ensure safe and legal shipments world wide.

Compliance and Quality

• GFS organic production operations are a zero discharge facility compliant with all local and federal EPA regulations

• We adhere to ISO 9001:2008 standards for quality practices and have been ISO certified since 1997

Organic Manufacturing

Leaders in the development and commercialization of specialty alkynes and derivatives

Product Offering

• GFS Chemicals remains focused on a core set of synthetic methodologies

• In support of alkyne production, we offer down

stream intermediates such as olefins, heteroaromatics and heterocycles

• We offer over 2000 organic chemicals in our product base

Core Synthetic Chemistry

Na & Li/Liquid Ammonia Chemistry– Alkylations– Aminations– Reductions (Birch, trans)– Ethynylations

Halogenations– Brominations– Chlorinations– Iodinations

Core Synthetic Chemistry

Alkyne Chemistry– Eliminations– Ethynylations– Sonogashira– Glaser Coupling– Cadiot-Chodkiewicz– Click Chemistry

Core Synthetic Chemistry

• Organometallic Chemistry– Grignard– Alkyl lithium– Coupling (Suzuki, Stille,

Negishi, Kumada)– Heck Reaction– LI/NA Amide– Cis-reductions

Core Synthetic Structures

• Alkynes– Aromatic– Terminal– Internal– Alcohols– Ketones– Acids– Conjugated

• Olefins– Cis/trans– En-yne– Cyclic– Grignards– Vinyl– Aryl– Alkyl

Core Synthetic Structures

• Halogenated Organics– Alkynes – Olefins– Alkyl– Aromatic

• Heteroaromatic– Quinolines – Indoles– Pyrimidines– Bipyridines– Phenanthrolines– Terpyridines

Core Synthetic Methodologies

• Alkyne Chemistry• Birch Reductions• Halogenation• Dehydrohalogenation• Alkylation(NH3 or other)• Sonogashira Reactions• Kumada Couplings• Cadiot-Chodkiewicz• Suzuki Coupling

• Diels-Alder Synthesis• Trans Reductions(NH3)• Barbier Reaction• Skraup Synthesis• Heck Reaction• Grignard/Alkyl Lithium

Synthesis• Finklestein Reaction• Phase Transfer

Kilo Lab Operations

• Multiple bench top operation• Glassware up to 72 L scale• Distillation support up to 50L scale

– Short path• Bench Strip• Rotary Evaporators

– Long path• 18” to 48” packed columns• Stainless, Hastelloy, Ceramic

packing

Pilot Scale Operations

– 10 gal – 100 gal Glass– 10 gal – 200 gal Stainless– Distillation Support

– Rotary Evaporator– 30 gal – 50 gal glass

lined steel distillation pots– 4’ to 12’ columns– Glass, Stainless &

Hastelloy packing

Plant Operations

– 350-500 gal Hastelloy– 100-1000 gal Glass – 200-1000 gal Stainless– Distillation support

• Short path– 50 gal-500 gal glass lined

• Long path– 4’ to 16’ column– Stainless, Hastelloy, Glass

packing– Solids Handling

• Hastelloy and Stainless centrifugation

Common Bulk Raw Materials

• Acetylene• Ammonia,liq.• Alkyllithium• Carbon disulfide• Chloroformates• Chlorosulfonic acid• Epichlorohydrin• Ethylene oxide• Bromine

• Lithium amide • Lithium metal• Magnesium• Sodium amide• Sodium hydride • Sodium metal• Trialkylsilanes• Iodine• Hydrogen Chloride

Robust Distillation Capabilities

• Increased capacity:– Single pass distillation– Fractional distillation

• High vacuum capability• Wiped film distillation for heat-

sensitive compounds• Extensive glass equipment for

handling corrosives• Low trace metal impurities

Inorganic Bulk Manufacturing

U.S. Based Inorganic Product Development and Manufacturing

Inorganic Specialties

• Perchloric acid & Salts• Ceric Ammonium Nitrate (Etchants & Catalysis)• Purified compounds for metal complexes• Ultra dry salts for moisture sensitive applications• Rare Earths, Lithium, Sodium and Magnesium salts

& solutions• Precious metal ion exchange resins

Bulk Inorganic Salts

• Nitrates • Sulfates• Chlorides• Perchlorates• Carbonates• Periodates

• Oxalates• Acetates• Formates• Phosphates• Citrates

GFS Catalog Operations

• 70,000 Sq Ft. Operation, Manufacturing and Distribution Center

• Repack and Fulfillment Center• Private Label Operation• Amco Clear Water Analysis Division• Bottling Operations• Quality Control Labs• Manufacturing and Sourcing over 4000

Analytical Reagents

In-House Quality Control Support

• Full wet chemistry lab• HPLC• GC (multiple)• GC/MS• UV/Vis• Karl Fischer• FTIR• Melting & Boiling

Point

• pH & Conductivity• Coulometric Karl

Fischer• Volumetric Karl Fischer• Ion Chromatography• ICP• AA

Customer Metrics

• Inventory Availability • Lead Time Accuracy• Product Quality• Timely Delivery• Product Information/Knowledge• Customer Satisfaction

International Operations

• Sourcing Operations in Beijing China• Serving over 80 countries

worldwide• www.GFSInternational.com

– Japanese– German– French– Spanish