Post on 09-Jul-2020
14th International Symposium on the
Genetics of Industrial
Microorganisms
Programme
8 - 11 September 2019Pisa · Italy
www.gim2019.org
INDEX
Organisation 4
Welcome 5
General information 7
Information for speakers and poster presenters 8
Social events 9
Programme 11
Sunday 11
Monday 12
Tuesday 14
Wednesday 16
Poster overview 18
314th International Symposium on the Genetics of Industrial Microorganisms
WELCOME
Dear participants, Dear colleagues,
It is a great pleasure to welcome you to the International Symposium on the Genetics of Industrial Microorganisms in Pisa.
This event is organized together with the Italian Society of General Microbiology and Microbial Biotechnology (SIGMBM) and with the support of the GIM International Committee.
During the 3,5 conference days, you will experience a diverse programme that includes keynote sessions, free paper sessions, industry symposia and poster presentations. You will get a unique opportunity to meet experts within the field and be updated on different aspects related to industrial microorganisms.
The scientific programme encompasses a wide range of topics within industrial microorganisms and we hope you find it inspiring.
Furthermore, we have arranged some social events and we hope you will get the chance to experience the historical side of the town.
We hope you will enjoy the conference and your stay in Pisa!
On behalf of the local organising committee and the scientific committee,
Stefano DonadioSymposium Chair
ORGANISATION
GIM International Committee
President:Zixin Deng
Members:Arnold DemainDavid HopwoodDavid WuEric CundliffeGuo-Ping ZhaoJaroslav SpizekJose Luis BarredoJulian DaviesJung-Hye RoeLixin ZhangSang-Ki RheeSergio Sanchez EsquivelTadayuki ImanakaStefano DonadioEriko TakanoHrovje PetkovicRoel BovenbergHilde SchrempfIan MacreadieJuan F. Martin
The Local Organising Committee
Stefano Donadio (Symposium Chair)Emilia GhelardiArianna TavantiFrancesco IannelliMarco VenturaDuccio CavalieriMariagrazia PizzaEzio RiccaPaolo ViscaAlessio MengoniRenato FaniGianni Pozzi
www.gim2019.org
4 514th International Symposium on the Genetics of Industrial Microorganisms
GENERAL INFORMATION
Conference websitewww.gim2019.org
Conference venuePallazzo dei Congressi Di PisaVia Giacomo Matteotti, 1,56124 Pisa PI, Italy
BadgesThe conference name badges must be worn at all times during the conference. Access to the conference venue will not be granted without the name badge issued by the conference organizers.
Entitlements for participants Admission to all scientific sessions and admission to exhibition, coffee breaks and lunch, welcome reception on Sunday 8 September, programme booklet, online access to all conference abstracts and certificate of attendance.
Conference languageThe conference will be held in English.
WIFIFree access to the WIFI at Pallazzo dei Congressi Di Pisa.
Mobile phonesAll mobile phones must be on silent mode during the sessions.
Certificates of attendanceIf you wish to have a certificate of attendance, please log in to the online registration again after the conference and follow the instructions to download your certificate. Should you need any help with this, please contact the secretariat at info@cap-partner.eu
Lost and foundFound items should be returned to the registration desk. If you lose something, please report to this desk for assistance.
First aidIn case of emergency or need of medical assistance, please contact the Conference Secretariat staff at the registration desk or any of the staff at the venue. First aid equipment is available at the venue.
Conference SecretariatCAP PartnerNordre Fasanvej 113, 2DK-2000 FrederiksbergDenmarkinfo@cap-partner.eu
www.cap-partner.eu Tel.: +45 70 20 03 05
6 714th International Symposium on the Genetics of Industrial Microorganisms
INFORMATION FOR SPEAKERS AND POSTER PRESENTERS
SpeakersPlease bring your presentation to the Speakers’ Preparation room at the venue. An assistant will help you upload the presentation to the computer. Please make sure to upload your presentation at least 60 min. before your session starts. Please bring your presentation on a USB stick. We do not allow the use of personal laptops for presentations. At the end of the conference, all presentations will be deleted in order to secure that no copyright issues will arise.
Poster presentersPoster can be mounted from Sunday 8 September at 14.00 and should be mounted by Monday 9 September at 10.00 at the latest. The secretariat will provide all necessary equipment for mounting of posters. Poster should be removed after the last session on Wednesday 11 September.
Kindly note that the secretariat takes no responsibility for left or damaged posters.
Poster sessions are held on:
• Monday 9 September 17.30 - 19.30• Tuesday 10 September 16.30 - 18.30
SOCIAL EVENTS
Welcome ReceptionDate 8 September 2019Time 18.30 - 20.30Place Palazzo dei Congressi de Pisa
Meet old and new colleagues for an informal welcome reception, held at Pallazzo dei Congressi de Pisa at 18.30 - 20.30. The reception is included in the registration fee.
GIM Conference DinnerDate 10 September 2019Time 20.00 - 24.00Place Santa Caterina Cloister
Piazza Santa Caterina 4 – Pisa
Get a chance to spend an evening with colleagues and new acquaintances in an informal atmosphere while enjoying a delicious meal and local wines. The dinner ticket is NOT included in the registration fee – a separate ticket is required.
8 914th International Symposium on the Genetics of Industrial Microorganisms
Sunday14.00 Registration opens16.00-16.30 Opening ceremony16.30-17.30 Plenary Lecture 1:
The CRISPR craze: from adaptive immunity to the genome editing revolutionSpeaker: Rodolphe Barrangou, USAChair: Duccio Cavalieri, Italy
17.30-18.30 Plenary Lecture 2: Theoretical biophysics/Computational systems biologyEdda Klipp, GermanyChair: Wolfgang Wohlleben, Germany
18.30-20.30 Welcome Reception
PROGRAMME 8 September 2019
10 1114th International Symposium on the Genetics of Industrial Microorganisms
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Monday08.00 Registration opens9:00-10:00 Plenary Lecture 3: Engineering bacterial envelops for vaccine delivery
Speaker: Rino Rappuoli, ItalyChair: Mariagrazia Pizza, Italy
10:00-10:30 Coffee break & Exhibition10:30-12:30 Plenary - Room 1 Room 2 Room 3
S1: Regulation of secondary metabolism
S2: Microbial enzymes and applications
S3: Microorganisms as drugs
Chairs: Gilles van Wezel,The NetherlandsNadine Ziemert, Germany
Chairs: Marco Moracci, ItalyJozef Anné, Belgien
Chairs: Emilia Ghelardi, ItalyJan Maarten Van Dijl, The Netherlands
10:30-10:55 Omic Insights into Natural Product DiscoveryPaul Jensen, United States
The discovery story of recent transformative enzyme solutions from NovozymesMartin Borchert, Denmark
Pathogen-pathogen inter-actions in the microbiome, a way to soothe virulence?Jan Maarten van Dijl, The Netherlands
10:30-10:4010:55-11:20 Small non-coding RNAs in
Streptomyces coelicolor - important regulators of central metabolism and antibiotic productionBeatrix Süß, Germany
Biotechnological processes with robust microbes and enzymesGarabed Antranikian, Germany
Staphylococcus lugdunensis as probiotic against nasal Staphylococcus aureus colonizationBernhard Krismer, Germany
10:40-11:05 11:20-11:45 De novo identification of
regulatory networks and applications for natural product discoverySebastien Rigali, Belgium
Thermophilic Archaea from genome to function and applicationBettina Siebers, Germany
Engineering microbes to rewire host-microbiome interactionsMatthew Wook Chang, Singapore
11:05-11:3011:45-12:00 Regulatory and mutational ana-
lysis of the biosynthetic gene cluster for ludunomycin, a novel antibiotic with unprecedented chemical architectureHelga van der Heul, The Netherlands
Exploring Novel Bacterial Terpene synthaseGajendar Komati, United Kingdom
Homology-independent pre-diction of subcellular protein localization in beneficial and engineered microbesStefano Grasso, The Netherlands
11:30-11:4512:00-12:15 Systems biology of secondary
metabolites: Deciphering nutrient impact on pamamycin production in a heterologous Streptomyces albus strain J1074/R2Lars Gläser, Germany
Characterization of the gamma-glutamylethanolamide synthetase GlnA4 in Streptomyces coelicolor as a potential industry relevant enzymeSergii Krysenko, Germany
Using yeast to screen for proteostasis inducing drugs to prevent Alzheimer's diseaseIan Macreadie, Australia
11:45-12:0012:15-12:30 Specific 23S ribosomal RNA
mutations conferring erythro-mycin resistance can enhance the frequency of spontaneous mutations in Streptomyces strains perturbing their secondary metabolismKanata Hoshino, Japan
Metagenomics of geothermal environments led to discovery of microbial enzymes for biotechnological applicationsRoberta Iacono, Italy
Antagonistic effects of Lactobacillus Cell Free Supernatants versus uro-genital pathogensMaria Santagati, Italy
12:00-12:15Probiotic Bacillus clausii strains: characterization and potential health benefitsFrancesco Celandroni, Italy
12:15-12:3012:30-14:00 Lunch, Exhibition & Poster viewing
Monday - continued14:00-15:00 Plenary Lecture 4: Small-molecule inhibitors of bacterial RNA polymerase: myxopyronins
Speaker: Richard Ebright, United States Chair: Stefano Donadio, Italy
15:00-15:30 Coffee break & Exhibition15:30-17:30 Plenary - Room 1 Room 2 Room 3
S4: Challenges in the disco-very of new antibiotics
S5: Vaccine discovery and production
S6: Synthetic biology for fine chemicals
Chairs: Alessandra Polissi, ItalyRichard Ebright, United States
Chairs:Mariagrazia Pizza, ItalyTiziano de Rosa, The Netherlands
Chairs:Francesco Del Carratore, United KingdomEdda Klipp, Germany
15:30-15:55 Deciphering antimicrobial drug interactions using highthroughput approaches Ana Rita Brochado, Germany
Bacterial Vaccines: past, present and future Mariagrazia Pizza, Italy
Boolean Network-based Approaches for Controlling Genetic Networks and Metabolic NetworksTatsuya Akutsu, Japan
15:55-16:20 Natural product discovery in the genomic era: Novel ansamycin antibiotics active on drug resistant tuberculosisJeff Errington, United Kingdom
A manufacturing platform for the production of a vaccine against invasive disease due to extraintestinal pathogenic Escherichia coli Tiziano deRosa, The Netherlands
Designing BiologyRamya Prathuri, United States
16:20-16:45 Next-Generation Fidaxomicin AntibioticsKarl Gademann, Switzerland
GMMA technology: from the development of vaccines for enteric diseases to multivalent vaccines Francesca Micoli, Italy
Mass microscope in microbiologyShuichi Shimma, Japan
16:45-17:10 Unusual and novel antibiotics from actinomycetesSonia Maffioli, Italy
Pathogen-pathogen inter-actions in the microbiome, a way to soothe virulence?Andrea Nayelli Garcia Pérez, Netherlands
16:45-17:00
Production of purple pigment, Violacein and Deoxyviolacein by genetically engineered E. coli.Toshihiko Morita, Japan
16:45-17:0017:10-17:20 A heterologous expression
platform for the production of cryptic lantipeptide antibiotics Abigail Alford, United Kindom
Novel approaches to vaccination: Immunisation with engineered, autologous T-lymphocytes to teach theimmune system how its owncells would appear if infectedby an immunodeficiency virusMauro Pistello, Italy
17:00-17:15
The Discrete Acyltransferase KirCII - A Potential Tool for "Bioderivatization" of Polyketide CompoundsEwa Maria Musio-Kroll, Germany
17:00-17:1517:20-17:30 Mining for antifungals from
bacterial soil isolatesMarija Mojicevic, Serbia
Integrated Probabilistic Anno-tation (IPA): A Bayesian-based annotation method for meta-bolomic profiles integrating biochemical connections, iso-topes patterns and adduct relationships Francesco Del Carratore, United Kingdom 17:15-17:30
17:30-17:40 Setting up in vivo screening of inhibitors of the E. coli Lipo-polysaccharide transport (Lpt) system assembly ElisabeteCardoso Mendez Moura, Italy
17:30-19:30 Poster session & Exhibition17:45-18:15 Explora Biotech Symposium: Bridging the gap between design and synthesis.
Speakers: Davide De Lucrezia & Dario Cecchi.
Programme 9 September 20199 September 2019
12 1314th International Symposium on the Genetics of Industrial Microorganisms
Tuesday08.00 Registration opens9:00-10:00 Plenary Lecture 5: Biotechnology of the Human Microbiome - Targets and Therapies for
the TractSpeaker: Willem de Vos, The Netherlands Chair: Marco Ventura, Italy
10:00-10:30 Coffee break & Exhibiton10:30-12:30 Plenary - Room 1 Room 2 Room 3
S7: Physiology and differentiation of industrial microorganisms
S8: Biodegradation and biocontrol
S9: Genome editing tools
Chairs:Ezio Ricca, ItalyEvi Stegmann, Germany
Chairs:Hilde Schrempf, GermanyRadka Chaloupkova, Czech Republic
Chairs:Arianna Tavanti, ItalyTilmann Weber, Weber
10:30-10:55 Allochthonous Bacillus and Their Role in the GI-TractSimon M. Cutting, UnitedKingdom
Next generation bacteriophages for improved biocontrol and diagnostics of pathogenic bacteriaMartin Loessner, Switzerland
A CRISPR-based toolkit to engineer actinomycete genomesTilmann Weber, Denmark
10:55-11:20 Streptomyces coelicolor, surprises from a model organismGilles van Wezel, The Netherlands
The elaborate protein-repertoire supporting the multifaceted biocontrol -strategies of streptomycetes.Hilde Schrempf, Germany
Genome Engineering of Non-model OrganismsHuimin Zhao, United States
11:20-11:45 Metabolomics for the Discovery of New Bioactive CompoundsMargherita Sosio, Italy
Microbial enzymatic systems for converting agro-industrial waste to useful compoundsPimchai Chaiyen, Thailand
CRISPR technologies for genome engineering and evolution of Baker’s yeast Saccharomyces cerevisiae Michael Krogh Jensen, Denmark
11:45-12:00 Streptomyces coelicolor extracellular vesicles carry proteins involved in morpho-physiological differentiationGuiseppe Gallo, Ttaly
Fatty acid degradation in sulfolobus acidocaldariusXiaoziao Zhou, Germany
Direct quantification and localization of efflux pumps in biofilm-associated bacteria through superresolution microscopyTiziano Vignolini, Italy
12:00-12:15 A heat-labile regulatory protein mediates spore coat formation in Bacillus subtitlesRachele Isticato, Italy
Isolation and characterisation of UAE-native microbes with hydrocarbon-degrading and biosurfactant production potentialRunzararoM Nyadzayo, United Arab Emirates
Generation of genomic synthetic integration sites in StreptomycesPedro Albuquerque, Portugal
12:15-12:30 The regulon of the extracytoplasmic function sigma factor SigE in Corynebacterium glutamicumKoichi Toyoda, Japan
Sulfur oxidising bacteria from contaminated dredged sediment: the plasticity of an autochtonous Thioalkalivibrio sp. isolate for the biocontrol of ghas emissionsSimona Di Gregorio, Italy
Crispr-Cas technologies revolutionizing strain improvment : the case of industrial solvantogenic ClostridiaNicolas Lopes Ferreira, France
12:30-13:30 Lunch, Exhibition & Poster viewing
Tuesday - continued13:30-14:30 Plenary Lecture 6: Posttranslational Modifications during Cyclic Peptide Biosynthesis
Speaker: Wilfred van der Donk, United StatesChair: Zixin Deng, China
14:30-16:30 Plenary - Room 1 Room 2 Room 3S10: Biosynthetic pathways
S11: Gut microorganisms and their applications
S12: Targets and leads for antifungals
Chairs:Zixin Deng, ChinaBarrie Wilkinson, United Kingdom
Chairs:Marco Ventura, ItalyDouwe van Sinderen, Ireland
Chairs:Axel Brakhage, GermanyIan Macreadie, Australia
14:30-14:55 Discovery and biosynthesis of new ribosomally-synthesised natural productsAndrew Truman, United Kingdom
Molecular genetics of bifidobacteria: a long and winding roadDouwe van Sinderen, Ireland
New avenues for the discovery and development of antifungal compoundsAxel Brakhage, Germany
14:55-15:20 Basic microbiology, chemistry and synthetic biotechnology to identify and characterize antibiotics from microbesRolf Müller, Germany
Old antifungals: antifolates and boron-containing compounds Ian Macreadie, Australia
15:20-15:45 Aminoglycoside Gentamicins: From Understanding to CreatingYuhui Sun, China
Transfering key genes in Bacteroides to metabolize complex dietary arabinogalactansJose Munoz, United Kingdom
Next generation Antifungal Drug DevelopementDavid Perlin, United States
15:45-16:00 Fungal Biosynthesis of Cyclic Peptides with Unique Chemical PropertiesThomas Schafhauser, Germany
Beyond the tip of the iceberg: illuminating bacterial dark matter through a combination of metagenomics and culturomic approachesGabriele Andrea Lugli, Italy
MAPK signalling pathways cross-talk interaction modulates the production of melanins in Aspergillus fumigatusVito Valiante, Germany
Biocontrol potential of Pseudomonas sp. DSMZ 13134 against the fungal forest pathogens Heterobasidion spp.Martina Pellicciaro, Italy
16:00-16:15 New insights into the biosynthesis of the Gq inhibitor FR900359Max Crüsemann, Germany
The role of TolC outer membrane channel and indole in the regulation of acid resistance in Escherichia coliTakeshi Kanda, Japan
16:15-16:30 Fluorescence-based screening of heterologously expressed biosynthetic pathways in eukaryotesJohann E. Kufs, Germany
The human gut microbiota is shaped by the engraftment of bovine bacteria vectored by milk productsChristian Milani, Italy
16:30-18:30 Poster session & Exhibition20:00-24:00 Congress dinner
10 September 201910 September 2019Programme
14 1514th International Symposium on the Genetics of Industrial Microorganisms
Wednesday08.30 Registration opens9:00-10:00 Plenary Lecture 7: In vitro pseudo-natural product biosynthesis and selection
Speaker: Hiroaki Suga, JapanChair: Hilde Schrempf, Germany
10:00-10:30 Coffee break & Exhibition10:30-12:30 Plenary - Room 1 Room 2 Room 3
S13: Novel bioactive compounds
S14: Aromas and volatiles and their applications
S15: Engineering primary metabolism for strain improvement
Chairs:Olga Genilloud, SpainRolf Müller, Germany
Chairs:Duccio Cavalieri, ItalyPaolina Garbeva, The Netherlands
Chairs:Paola Branduardi, ItalyHrvoje Petkovic, Slovenia
10:30-10:55 Jens Glaeser, Germany Plant terpenes, glycosylation and how to keep them safeRumyana Karlova, The Netherlands
Synthetic strategies for production of aromatic molecules in KluyveromycesmarxianusJohn Morrissey, Ireland
10:55-11:20 Novel inhibitors of the ribosome and protein synthesisDaniel Wilson, Germany
Bacterial aerial clash: volatiles as antimicrobialsMariana Garcia Avalos, The Netherlands
A field of dreams: Lignin valorization into bio-based chemicals and materialsChristoph Wittmann, Germany
11:20-11:45 Novel ansamycin antibiotics with activity towards MDR-Mycobacterium tuberculosisNick Allenby, United Kingdom
The role of yeast in chemical signaling to insectsDuccio Cavalieri, Italy
Biotechnological terpene production – Construction of alternative hosts and expansion of the cellular building block repertoireMarkus Buchhaupt, Germany
11:45-12:00 Investigation of Planomonospora as Specialised Metabolite Producer by Metabolomic ToolsMitja Zdouc, Italy
Harnessing plant-associated bacteria and their volatiles for crop protectionMout De Vrieye, Switzerland
Optimization of the brasilicardin biosynthesis in actinomycetesEvi Stegmann, Germany
12:00-12:15 Novel manumycin-type anti-inflammatory compounds by means of genetic screening and gene shufflingKateřina Petříčková, Czech Republic
Attractive behavoiur of Saccharomyces cerevisiae and Lactobacillus casei on paper wasp Polistes dominulaNiccolò Meriggi, Italy
Bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicumChristina Rohles, Germany
12:15-12:30 New puromycin like metabolites from Escovopsis weberiEdward Hems, United Kingdom
Exploring microbial intersections for discovery of novel volatile compoundsPaolina Garbeva, The Netherlands
Development of Streptomyces to Utilise Sustainable Feedstocks in FermentationsAnna Birke, United Kingdom
12:30-13:30 Lunch, Exhibition & Poster viewing
Wednesday - continued13:30-15:30 Plenary - Room 1 Room 2 Room 3
S16: Bioinformatic tools and big data approaches
S17: Novel industrial microorganisms and approaches
S18: Microorganisms for food and agricultural applications
Chairs:Alessio Mengoni, Italy Marnix Medema, The Netherlands
Chairs:Daniel Lopez, SpainMiaomiao Liu, Australia
Chairs:Roel Bovenberg, The NetherlandsRaffaella Di Cagno, Italy
13:30-13:55 Large-scale discovery of novel strains and species in the global human microbiomeNicola Segata, Italy
Daniel Lopez, Spain How the lactobacilli adapt to and perform in food ecosystemsMarco Gobbetti, Italy
13:30-13:5213:55-14:20 Large-scale genome
sequence analysis and plant-microbe interactionsRebekah Kelly, United States
Pantoea ananatis AJ13355: Genetics, Metabolism and Industrial ApplicationsJoanna Katashkina, Russian Federation
Inspiration for innovation in bakeryFabienne Verté, Belgium
13:52-14:14
14:20-14:45 A roadmap to integrated metabolome and genome mining analysisJustin van der Hooft, The Netherlands
Target Identification by Direct Observation of Protein-Ligand Complexes Using Native Mass SpectrometryMiaomiao Liu, Australia
Microbial small molecules - weapons of plant subversionRonnie de Jonge, The Netherlands
14:14-14.3614:45-15:00 The antiSMASH platform, a web
application and database for mining microbial genomes for secondary metabolite clusters.Kai Blin, Denmark
Exploring the biosynthetic potential of the rare actinomycete Streptoalloteichus sp NAI85712Emilia Palazzotto, Denmark
Biotechnological production of agrochemicals at BASFHartwig Schroeder, Germany
14:36-15.0015:00-15:15 New bioinformatics tools
help the discovery of natural products produced by the actinomycete genus AmycolatopsisMartina Adamek, Germany
Genome-scale model guided study of Planobispora rosea, the natural producer of GE2270A for TOPCAPI project (Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients)Kamila Schmidt, United Kingdom
High quality soil and insect-associated microbial collections as source of novel natural productsSanja Mihajlovic, Germany
15:15-15:30 Predicting consumer beer preference with artificial intelligence: a lesson on yeast’s important roleSupinya Piampongsant, Belgium
Going smaller : How ‘debugged’ Bacillus subtilis behaves as a cell factoryRocio Aguilar Suarez, The Netherlands
development of omics-based quality control of multi-strain formulations marketed as probioticsRossella Filardi, Italy
15:30-16:00 Coffee break & Exhibition16:00-17:00 Plenary Lecture 8:
Deciphering and exploiting beneficial mycorrhizal fungiSpeaker: Paola Bonfante, ItalyChair: Roel Bovenberg, The Netherlands
17:00-17:30 Closing ceremony & Poster prizes
11 September 201911 September 2019Programme
16 1714th International Symposium on the Genetics of Industrial Microorganisms
No. Title Category Final First Name Last NameP1 Streptomyces coelicolor as cell factory for
the production of a metagenome-sourced chitinase with insecticide activity
Biodegradation and biocontrol
Francesca Berini
P2 An unusual type of glycerol-3-phosphate dehydrogenase is involved in glycerol degradation in Sulfolobus acidocaldarius
Biodegradation and biocontrol
Christian Schmerling
P3 The role of quorum sensing in degradation of monoaromatic hydrocarbons by Pseudomonas putida AQ8
Biodegradation and biocontrol
Simone Di Gregorio
P4 Transcriptomics of bacterial small RNA: improved detection and expression analysis by combining differential RNA-seq and microarray data
Bioinformatic tools and big data approaches
Antonio Rodríguez-García
P5 Development of novel tools for high-throughput genomic and metagenomic analyses - from genomes annotation to resistomes analyses
Bioinformatic tools and big data approaches
Mikolaj Dziurzynski
P6 Genome mining and comparative genome analysis to explore Enterobacteria as heterologous hosts for secondary metabolites
Bioinformatic tools and big data approaches
Omkar Mohite
P7 Identification of small RNA genes from differential RNA-seq data: a detailed workflow for bioinformatics detection and manual annotation
Bioinformatic tools and big data approaches
Antonio Rodríguez-García
P8 Using Actinobacteria strains to benchmark genome sequencing technologies and genome assembly strategies
Bioinformatic tools and big data approaches
Tue Sparholt Jørgensen
P9 Enzyme-level perturbations by CRISPRi reveal control principles of E. coli primary metabolims
Bioinformatic tools and big data approaches
Stefano Donati
P10 Novel strategies for the biosynthesis of protease inhibitors in bacteria
Biosynthetic pathways Leonard Kaysser
P11 Biosynthesis of deoxysugar phosphoramidate metalloprotease inhibitors
Biosynthetic pathways Marius Bader
P12 Identification, cloning and heterologous expression of the gene cluster encoding RES-701-3 and RES-701-4 biosynthesis
Biosynthetic pathways Daniel Oves-Costales
P13 addition of formate dehydrogenase increases the production of renewable alkane from an engineered metabolic pathway
Biosynthetic pathways Juthamas Jaroensuk
P14 Identification of the target and self-resistance mechanism of obafluorin, a ß-lactone antibiotic
Biosynthetic pathways Sibyl Batey
P15 Biosynthesis of the cyclopropyl moiety of belactosin A
Biosynthetic pathways Alicia Engelbrecht
P16 Pseudomonas fluorescens as a production platform for the characterisation and engineering of bicyclomycin biosynthesis
Biosynthetic pathways Natalia M. Vior
P17 Characterization of a type II polyketide synthase (PKS) cluster in the rare actinomycete Kutzneria sp. 1627
Biosynthetic pathways Erika Corretto
P18 structural basis of the pks thioesterase domain directed the engineering of polyene chian release
Biosynthetic pathways Yucong Zhou
No. Title Category Final First Name Last NameP19 Identification and application of
ansamitocin transporters efficiently improved ansamitocin-p3 yield
Biosynthetic pathways Xinran Wang
P20 atp/adp-dependent carbamoylations in the biosynthesis of ansamycins
Biosynthetic pathways Jianhua Wei
P21 Design, tuning and application of antibiotic specific biosensors in Actinobacteria
Challenges in the discovery of new antibiotics
Yuriy Rebets
P22 Screening for antimicrobial activities of Actinobacteria isolated from cave moonmilk deposits
Challenges in the discovery of new antibiotics
Delphine Adam
P23 Characterization of the cystargolides as protease inhibitors
Challenges in the discovery of new antibiotics
Nicole Staudt
P24 Engineering the aromatic degradation and transport system of Pseudomonas putida strains for elevated production of Polyhydroxyalkanoates on low-cost substrates
Engineering primary metabolism for strain improvement
Ignacio Poblete-Castro
P25 Engineering glucose transporters and its effect on metabolite production in E. coli
Engineering primary metabolism for strain improvement
Min-Kyu Oh
P26 Towards 3G bio-production from ocean farms: Systems metabolic engineering of Corynebacterium glutamicum for the production of L-lysine from the major seaweed ingredient mannitol
Engineering primary metabolism for strain improvement
Sarah Hoffmann
P27 Identification of genes involved in steroid resistence in Mycolicibacterium (Mycobacterium) neoarum by 'omics analyses
Engineering primary metabolism for strain improvement
Antonio Rodríguez-García
P28 Metabolic engineering of E. coli for Oligosaccharides production
Engineering primary metabolism for strain improvement
Pietro Tedesco
P29 Reconstruction of methanol assimilation pathway in Escherichia coli for methanol utilization
Engineering primary metabolism for strain improvement
Hirotaka Yajima
P30 Increased Xylitol production by genetically engineered Candida Guilliermondii
Engineering primary metabolism for strain improvement
Alexander Zwirzitz
P31 One Yeast Strain to Rule Them All: Primary Metabolism Engineering to Obtain Industries Precious Production Strain
Engineering primary metabolism for strain improvement
Ainsley Beaton
P32 CRISPRi-based titration of transcriptional feedback improves growth of arginine-producing E. coli by balancing overproduction with pyrimidine biosynthesis.
Engineering primary metabolism for strain improvement
Timur Sander
P33 CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes
Genome editing tools Yaojun Tong
P34 Engineering Corynebacterium glutamicum with a comprehensive genomic library and phage-based vectors
Genome editing tools Filipe Marques
P35 Improved Tools for Engineering Streptomyces
Genome editing tools Charlotte Beck
P36 Deletion of FK506 biosynthesis cluster in Streptomyces tsukubaensis by an improved Cas9-CRISPR system
Genome editing tools Antonio Rodríguez-García
POSTER OVERVIEW
18 1914th International Symposium on the Genetics of Industrial Microorganisms
No. Title Category Final First Name Last NameP56 Bioactive Amycolatopsis sp. from the
mongolian steppe: identification of secondary metabolites and genome mining yielding novel lasso peptides
Novel bioactive compounds
Jaime Felipe Guerrero Garzón
P57 a hybrid metabolite of isocoumarin and indole alkaloid from an endolichenic fungus aspergillus sp.
Novel bioactive compounds
Minghua Chen
P58 Rescrutiny of sansanmycin biosynthetic gene cluster leads to the discovery of a novel sansanmycin analogue with more potency against Mycobacterium tuberculosis
Novel bioactive compounds
Yuanyuan Shi
P59Reactive oxygen species do not contributeapoptosis-like death by gold nanoparticles in Escherichia coli
Reactive oxygen species do not contribute apoptosis-like death by gold nanoparticles in Escherichia coli
Novel bioactive compounds
Dong Gun Lee
P60 Butyrate protects against high-fat diet-induced atherosclerosis via up-regualting ABCA1 expression in ApoE-deficiency mice
Novel bioactive compounds
Yu Du
P61 Silent secondary metabolite clusters activation by various regulatory proteins in Actinomycetes
Novel bioactive compounds
Erik Mingyar
P62 What are the roles of actinomycetes in human microbiome?
Novel bioactive compounds
Alica Chroňáková
P63 Identification and characterization of the biosynthetic gene cluster of the unprecedented glycosylated lanthipeptide MDN-0207
Novel bioactive compounds
Marina Sanchez-Hidalgo
P64 Small and macromolecule crystal structures solved with 3D electron diffraction: a new tool in nanocrystallography
Novel bioactive compounds
Iryna Andrusenko
P65 Structure elucidation by spectroscopic methods and biosynthetic gene cluster analysis of Krisynomycins A-C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus
Novel bioactive compounds
Mercedes Pérez-Bonilla
P66 3D electron diffraction: a single crystal method for nanocrystalline pharmaceutical compounds
Novel bioactive compounds
Mauro Gemmi
P67 Understanding the mechanism of action of the lanthipeptide NAI-112, an antinociceptive agent
Novel bioactive compounds
Arianna Tocchetti
P68 Identification and characterization of metabolites produced by Antarctic cold-active bacteria, and their application in various biotechnologies
Novel bioactive compounds
Michal Styczynski
P69 Caves: ancient and unexplored reservoir for antimicrobial compounds discovery
Novel bioactive compounds
Daniele Ghezzi
P70 Engineering atypical tetracycline formation in Amycolatopsis sulphurea for the production of modified chelocardin antibiotic
Novel bioactive compounds
Špela Pikl
P71 Genome Mining of Bioactive Molecules from Nocardia sp. CS682
Novel bioactive compounds
Dipesh Dhakal
No. Title Category Final First Name Last NameP37 Gene editing efficiently cuts out the
integrated human immunodeficiency virus genome from the host cell genome, but the virus has a chance to start over
Genome editing tools Michele Lai
P38 improved construct of b. breve site-directed mutagenesis vectors
Genome editing tools Emily Hoedt
P39 Berberine Inhibits Choline-Induced Atherosclerosis by Attenuating Trimethylamine and Trimethylamine-N-Oxide production via Manipulating the Gut Microbiota
Gut microorganisms and their applications
Xingxing Li
P40 Characteristics of respiratory microbiota in immunocompromised patients with pneumonia
Gut microorganisms and their applications
YEUN-JUN CHUNG
P41 Milk and sugar?: Metabolism of the predominant human milk oligosaccharide fucosyllactose by an infant gut commensal
Gut microorganisms and their applications
Kieran James
P42 An engineered Mycobacterium RipA enzyme enhances the vancomycin drug activity against Streptomyces coelicolor
Microbial enzymes and applications
Fernando Santos-Beneit
P43 New screening method for feruloyl esterase producing yeasts suitable for hydrolysis of plant and wood derived materials
Microbial enzymes and applications
Mª del Rosario
Pérez-Redondo
P44 metabolic engineering for the production of hydroxyl amino acids
Microbial enzymes and applications
Lu Shen
P45Identification of quorum quenching bacteriafrom a fish farm and their AHL-lactonase genes
Microbial enzymes and applications
Jung-Kee Lee
P46 Enzymes for industrial vegetable oil degumming
Microbial enzymes and applications
Maria Castelli
P47 A rapid procedure for the in situ assay of periplasmic, PQQ-dependent methanol dehydrogenase in intact single bacterial colonies.
Microbial enzymes and applications
Shreya Shaw
P48 identification of natural inulinase producing bacilli, for industrial applications
Microbial enzymes and applications
Claudia Petrillo
P49 Improved production, translocation and solubility of recombinant protein by low inducer concentration levels in E. coli
Microbial enzymes and applications
Eunyoung Jo
P50 Comparative genomics and deep phenotyping of the plant associated genus Ensifer
Microorganisms for food and agricultural applications
Alessio Mengoni
P51 enhancement of 1,40dihydroxy-e-naphthoic acid production by weissella sp fed-batch culture in protaetia brevitarsis extraction
Microorganisms for food and agricultural applications
SunMee Hong
P52 High quality soil and insect-associated microbial collections as source of novel natural products
Microorganisms for food and agricultural applications
Sanja Mihajlovic
P53 Application of Plant Growth Promoting Rhizobacteria (PGPR) for the improvement of agricultural productivity
Microorganisms for food and agricultural applications
Stefany Castaldi
P54 Anti-HCV Oxazinoindole Alkaloid with an Unprecedented Tetraheterocyclic Skeleton from a Marine-derived Penicillium sp
Novel bioactive compounds
Maoluo Gan
P55 Discovery of geninthiocin B from new lichen-associating Streptomyces sp.
Novel bioactive compounds
Olha Schneider
20 2114th International Symposium on the Genetics of Industrial Microorganisms
No. Title Category Final First Name Last NameP89 Mapping the regulons of sigma factors
in Streptomyces coelicolorPhysiology and differentiation of industrial microorganisms
Jan Bobek
P90 Role of DegQ-like protease in formation of cell surface structures of Corynebacterium glutamicum
Physiology and differentiation of industrial microorganisms
Masaaki Wachi
P91 Induction of glutamic acid production by copper in Corynebacterium glutamicum
Physiology and differentiation of industrial microorganisms
Takashi Hirasawa
P92 Analysis on the phenomenon for the phenotypic diversification of actinomycetes through isolation of their single colonies
Physiology and differentiation of industrial microorganisms
Ryo Morimoto
P93 Stress response to butyric acid and butanol formation in Clostridium beijerinckii at transcriptomic level
Physiology and differentiation of industrial microorganisms
Petra Patakova
P94 A truncated form of the coprohaem decarboxylase HemQ increases the oxidative stress in Lactococcus lactis subsp. lactis
Physiology and differentiation of industrial microorganisms
William Remelli
P95 A peculiar strain of Lactococcus lactis subsp cremoris is able to use citrate as a carbon source
Physiology and differentiation of industrial microorganisms
Tiziana Lorenzi
P96 Flow cytometry for better insight into the physiology of sporulating bacteria
Physiology and differentiation of industrial microorganisms
Barbora Branska
P97 cytosolic copper affects germination, development and secondary metabolism in streptomyces coelicolor
Regulation of secondary metabolism
Nathaly González-Quiñonez
P98 The sco1897 transcriptional regulator modulates germination, antibiotic production and sporulation
Regulation of secondary metabolism
gemma fernández-garcía
P99 Intriguing structural features of the angucycline-like antibiotic auricin and its complex regulation in Streptomyces lavendulae subsp. lavendulae CCM 3239
Regulation of secondary metabolism
Jan Kormanec
P100 Characterization of SfbR2, a pseudo-gamma butyrolactone receptor from Streptomyces filipinensis
Regulation of secondary metabolism
Eva G. Barreales
P101 Functional characterization of the gene encoding S-adenosyl-L-methionine synthetase in Penicillium chrysogenum
Regulation of secondary metabolism
Mª del Rosario
Pérez-Redondo
P102 Role of the PhoP transcription factor on filipin production and morphological differentiation in Streptomyces filipinensis
Regulation of secondary metabolism
Jesus F. Aparicio
P103 Subtle genetic adaptations driving pathogenicity behaviour in Streptomyces scabies
Regulation of secondary metabolism
Benoit Deflandre
P104 One cluster, different bioactive compounds: bagremycins and ferroverdins are produced by the same biosynthetic gene cluster
Regulation of secondary metabolism
Loïc Martinet
No. Title Category Final First Name Last NameP72 Tapping the potential for new bioactive
moleculesNovel bioactive compounds
Jenny Schwarz
P73 Biotechnological investigations of the halotolerant species Aspergillus oleamuriae sp. nov.
Novel industrial microorganisms and approaches
Martina Felli
P74 Exploring the biosynthetic potential of the rare actinomycete Streptoalloteichus sp. NAI85712
Novel industrial microorganisms and approaches
Emilia Palazzotto
P75 Construction of a transferable nisin-inducible host-vector system for heterologous gene expression in Gram-positive bacteria
Novel industrial microorganisms and approaches
Francesco Iannelli
P76 Industrial applications of different strains of Bacillus spp. isolated from decayed wood
Novel industrial microorganisms and approaches
Antonio Rodríguez-García
P77 Decayed wood as a new source of bioactive compounds
Novel industrial microorganisms and approaches
Mª del Rosario
Pérez-Redondo
P78 Strain improvement of Pseudoalteromonas haloplanktis TAC125 towards its industrial exploitation as cell factory
Novel industrial microorganisms and approaches
Concetta Lauro
P79 Dictyostelium discoideum as a source of natural products and expression host for polyketide synthases from amoebozoa
Novel industrial microorganisms and approaches
Christin Reimer
P80 Extra-cellular water soluble antioxidant properties of Pseudoalteromonas species according to culture media
Novel industrial microorganisms and approaches
Yehui Gang
P81 Investigating the metabolic potential of the rare actinomycete genus Actinospica.
Novel industrial microorganisms and approaches
Paolo Monciardini
P82 Antioxidant Properties of Bacillus subtilis subsp. inaquasorum Fermented Algal Biomass; An experiment carried out under saline conditions
Novel industrial microorganisms and approaches
Svini Marasinghe
P83 Metabolic flux analysis in Ashbya gossypii using 13C-labeled yeast extract: industrial riboflavin production under complex nutrient conditions
Physiology and differentiation of industrial microorganisms
Susanne Schwech- heimer
P84 A role of RNase E/G in transcriptional termination in Corynebacterium glutamicum
Physiology and differentiation of industrial microorganisms
Takahiro Kawame
P85 Exploiting the natural solvent tolerance of Pseudomonads for the production of plastic platform chemicals:
Physiology and differentiation of industrial microorganisms
Charles Begley
P86 genetics and physiological studies of a thermoanaerobacter kivui mutant lacking hdcr
Physiology and differentiation of industrial microorganisms
surbhi jain
P87 An engineered Mycobacterium RipA enzyme enhances the vancomycin drug activity against Streptomyces coelicolor
Physiology and differentiation of industrial microorganisms
Fernando Santos-Beneit
P88 Complex regulation of SigB family sigma factors of RNA polymerase in Streptomyces coelicolor A3(2)
Physiology and differentiation of industrial microorganisms
Beatrica Sevcikova
22 2314th International Symposium on the Genetics of Industrial Microorganisms
No. Title Category Final First Name Last NameP105 Molecular reprogramming of
Streptomyces albus for improved pamamycin production using microparticle enhanced cultivation
Regulation of secondary metabolism
Martin Kuhl
P106 Eliciting production of silent antimicrobial metabolites in Streptomyces spp. environmental isolates
Regulation of secondary metabolism
Kristiina Vind
P107 Study of Streptomyces sp. carbohydrate catabolic pathways as a means to antibiotic discovery
Regulation of secondary metabolism
Sinaeda Anderssen
P108 Total RNA purification from difficult samples: a high-producer mutant of Streptomyces cultivates in industrial conditions
Regulation of secondary metabolism
Mª del Rosario
Pérez-Redondo
P109 The DNA cytosine methylome of Streptomyces coelicolor
Regulation of secondary metabolism
Rosa Alduina
P110 Regulatory and mutational analysis of the biosynthetic gene cluster for ludunomycin, a novel antibiotic with unprecedented chemical architecture
Regulation of secondary metabolism
Helga van der Heul
P111 TOPCAPI: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients
Synthetic biology for fine chemicals
Jane Gilsenan
P112 Synthetic biology for the sustainable production of folate
Synthetic biology for fine chemicals
Paola Branduardi
P113 Natural-Vanillin Fermentation from sugar : Production on Industrial Scale
Synthetic biology for fine chemicals
Miku Matsuzawa
P114 Combinatorial Metabolic Engineering Approach for Cyanidin 3-O-glucoside Production in Escherichia coli
Synthetic biology for fine chemicals
Ramesh Pandey
P115 Investigation of biosynthesis of aromatic polyketide antibiotics by synthetic biology
Synthetic biology for fine chemicals
Dominika Csolleiova
P116 Production of antheraxanthin and violaxanthin in E. coli transformed with zeaxanthin epoxydase from plants
Synthetic biology for fine chemicals
Akiko Kubo
P117 Transcriptional cluster "refactoring" to access and expand nature's chemical diversity
Synthetic biology for fine chemicals
Liliya Horbal
P118 Heterologous expression of the GE2270 biosynthetic gene cluster in Streptomyces coelicolor
Synthetic biology for fine chemicals
Oksana Bilyk
P119 Metabolic profile engineering through transcriptional gene cluster "refactoring"
Synthetic biology for fine chemicals
Nikolas Eckert
24 2514th International Symposium on the Genetics of Industrial Microorganisms
Rare Biologically Active Antibiotics & Mycotoxins
www.adipogen.com
Unique Structures
Unique Activity Profiles
Lantibiotics
Pseudouridimycin/Rifamycins
Antitumor Agents
Immunosuppressives
Antifungals/Antivirals
Quorum Sensing Agents
BULK Available
Pseudouridimycin/Rifamycins
www.adipogen.com
Highlights at a Glance
Rare Biologically ActiveAntibiotics & MycotoxinsIntroductionThe definition of the term “antibiotics” has evolved and is much broader compared
to the past, when an antibiotic had to be produced by a microorganism and had to
be directed to bacteria or other microorganisms. Today antibiotics include next to
secondary metabolites isolated from microorganisms, semisynthetic derivatives and
chemically synthesized compounds (e.g. sulfonamides), which have antibacterial, anti-
microbial, antifungal and antiprotozoal or similar effects and are potentially useful as
antitumor agents, chemotherapeutic agents, enzyme inhibitors, hypocholesterolemic
agents, immunosuppressive agents, antimetabolites, plant growth modulators, feed addi-
tives, or inhibitors (insecticides, miticides, antiparasitics, phytotoxins, herbicides, etc.).
Antibiotics can be classified based on their mechanism of action (MoA), chemical struc-
tures, mode of production (fermentation, synthetic or semisynthetic), producing or-
ganisms (actinobacteria, fungi (incl. mycotoxins), filamentous bacteria) or spectrum
of activity. Some antibiotics inhibit cell wall biosynthesis, protein synthesis, nucleic
acid synthesis, metabolic pathways or interfer with cell membrane integrity. They also
can be classified by their molecular biological activities (anti-infective, anticancer and
other activities).
CONTENTSIntroduction
1–2Rifamycins 2Pseudouridimycin – UNIQUE! 3Selected Antibiotics (Antibacterial) 3Lantibiotics & Thiazolylpeptides (RiPPs)
4Quorum Sensing – Targeting the Bacterial Biofilm 5
Cancer Research 6–11• DNA/RNA Synthesis | H+-ATPase 6• Immunosuppressives 7• Immunometabolism | Microtubule 8• Proteasome | HSP90 | PP2A 9• Protein Kinase & Enzyme Modulation
10• HIF-1 | Other Anticancer Agents 11• CD1a Ligands 12
Natural Product Library Sets 12Metabolic Syndrome Research 13Inflammation & Neuroscience 14Other Antibiotics, Mycotoxins & Marine Agents 15
Key Research Antibiotics 16
FIGURE: Bioactive metabolites. Adapted from Antibiotics: Current innovations and future trends: S. Sanchez & A.L. Demain (2015)
AntibioticsAntibacterialsAntifungals
Phytotoxins
Enzyme Inhibitors
Herbicides
Plant GrowthRegulators
Antitumor
Antiviral
Feed Additives
Pesticides
Insecticides, Miticides
Antimetabolites
Antiparasitics
Mycotoxins
Immunological Active Agents
Antiparasitics
Tropodithietic acid Page 5
COOHO
S
S
OO
H3C CH3O
HO
OH
H
Heptelidic acid Page 8
O
HN O
O
CH3
Cl
OHHH
Salinosporamide A Page 9
VISIT THE ADIPOGEN LIFE SCIENCES BOOTH AT GIM2019 & GET YOUR FREE COPY
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