FUNCTIONAL ANATOMY OF

LIVER AND BILIARY TREE

16/01/2013

Dr SIVARAJ S

DEPT OF PHYSIOLOGY

ALL INDIA INSTITUTE OF MEDICAL SCIENCES

NEW DELHI

Hepatocytes secretory epithelial cells that separate the lumen of the bile canliculi from the endothelium of vascular sinusoids.

Bile Flow Hepatocytes Bile canaliculi

Terminal bile ducts

Hepatic duct

Common bile duct

HEPATOCYTES,SINUSOIDS, AND THE INTRAHEPATIC BILE SYSTEM

STRUCTURE OF BILIARY TREE

Liver has a dual blood supply, but a Single Venous Drainage system

Portal vein ~75% hepatic artery ~25% Portal venules+Hepatic arterioles

Hepatic sinusoids

Terminal hepatic venules(Cen.vein)

Hepatic veins Bile ducts mainly supplied by Rt.hepatic

artery

BLOOD SUPPLY TO THE LIVER

Classic hepatic lobule All hepatocytes drained by a

single central vein as the core which is bounded by 2 or more portal triads

Portal lobule All hepatocytes drained by a

single bile ductule and is bounded by 2 or

more central veins Portal acinus Small 3-Dimensional mass of

hepatocytes with one axis formed by line btw two triads(high Po2)and another axis formed by line btw two central veins(low Po2).

Zone I periportal hepatocytes most oxygenated most resistant to circulatory compromise or nutritional deficiency and first to regenarate

Zone II and Zone III exposed to lower conc. of nutrients and oxygen. Vulnerable to injury.

ZONES TO THE ACINUS

Thank you