Post on 31-Dec-2015
description
P1
FLT3 D835Y
P2
ASXL1 G642fs* NF1 intron 2
NPM1c L287Fs* (insTCTG) DNMT3A R882C
KRAS K117NTET2 L1119*
P3
CEBPA T310NT NRAS G12D
P5
IDH1 R132HNPM1c L287fs*
(insTCTG) FLT3 D835Y
P6
ASXL1 C594*
P7
DNMT3A G590fs* IDH2 R172K
TET2 P612fs* KRAS G12V
P4
NPM1c L287fs*(insTCTG) IDH2 R 140Q
WT1 R145fs* CEBPA A111fs*
P3
Supplementary Figure S2. Confirmation by capillary sequencing of 21 substitutions and indels identified by targeted pull-down. Chromatographs from AML samples P1-P7 (upper) are contrasted with normal DNA (lower). Arrows indicate substitutions and arrowhead indicate indels.