Post on 15-Apr-2017
DEFINATION: Epilepsy is a disorder in which there is a
tendency for the occurance of epileptic seizures.
CAUSES: 1.Ideopathic: Cause unknown 2.Symptomatic:
Trauma, metabolic disorders
Partial Seizures 1. Simple 2. Complex
Generalized seizures 1.Tonic-clonic 2. MyoclonicGeneralized epilepsy
1. Benign neonatal convulsion 2. Childhood absence
DRUGS USED IN EPILEPSY: BARBITURATES:
1. PHENOBARBITAL VALPROIC ACID OTHER AGENTS
A. FELBATOL (FELBAMATE) B. NEURONTIN (GABAPENTIN)
FLOATING TABLETS: EFFERVACENT NONEFFERVACENT
Oral route is the most preferred route of drug administration.Good patient compliance.Most of the drugs exhibit site specific absorption in GITFloating drug delivery system is one of the very good approach for controlled release of the drug
MATERIALS:
GABAPENTEIN HPMC GUARGUM Na BICARBONATE TARTARIC ACID Mg STERATE TALC NINHYDRIN
EQUIPMENTS
ELECTRONIC BALANCE
PUNCHING MACHINE
HARDNESS TESTER VERNIER CALIPERS DISSOLUTION
APPARATUS
EXPERIMENTAL: DRUG (GABAPENTEIN)
MIXED IN BLENDOR
PREPARATION OF GRANULES
PASSED THROUGH SIEVE NO 18
DRIED IN PROCESSOR
GRANULES ARE COMPRESSED TO TABLETS
EVALUATION OF TABLETS
Floating lag timeDuration of floatingDimensional stabilityWater uptake studyIn vitro dissolutionRelease kinetics: Zero – order release kinetics: First– order release kinetics: Higuchi (Diffusion) equation: Q = k2t1/2