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Subrata RoySr.Product Executive, PMDCell:01713-374737

Total antihistamine market in Bangladesh

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293.60 Cr.

IMS-1st Qtr-2015-MAT

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Generic Yearly Value CETIRIZINE 68.79 cr.

FEXOFENADINE 64.60 cr. KETOTIFEN 60.63 cr.

RUPATADINE 24 cr. DESLORATADINE 20 .64 cr. LEVOCETIRIZINE 14 .71 cr.

EBASTINE 12 .58 cr. LORATADINE 11.19 cr.

CHLORPHENAMINE 10.84 cr. HYDROXYZINE 5.54 cr.

IMS-1st Qtr-2015-MAT

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CETIRIZINE23%

FEXOFENADINE22%

KETOTIFEN21%

RUPATADINE8%

DESLORATADINE7%

LEVOCET-IRIZINE

5%

EBASTINE4%

LO-RATA-DINE4%

CHLORPHENAMINE4%

HYDROXYZINE2%

Value share (%) of various generic in Antihistamine market IMS-1st Qtr-2015-

MAT

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RUPATADINE

LEVOCETIRIZINE

HYDROXYZINE

FEXOFENADINE

DESLORATADINE

EBASTINE

KETOTIFEN

CETIRIZINE

CHLORPHENAMINE

0.00 10.00 20.00 30.00 40.00 50.00 60.00 70.00 80.00

67.93

48.77

27.77

15.45

11.54

10.52

10.29

3.47

0.82

Growth of Antihistamine market(%)

growth IMS-1st Qtr-2015-MAT

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Market Scenario of RupatadineTotal Market: 24 Cr. (67.93% growth)

Ref: IMS_1st quarter_MAT_2015

Brand CompanyValue (Cr.)/

Month

Value (Cr.)/ year

Growth(%)

RUPA Aristopharma .73 8.76 26.57

RUPADIN Beacon .27 3.23 17.95

MINISTA Radiant .26 3.14 999.00

DIPA Drug Intl. .18 2.17 81.15

RUPIN Ziska .15 1.88 59.98

RUPATROL Square .10 1.20 29.19

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Brand Company NAT Sh.

RUPA Aristopharma 23.48RUPIN Ziska 17.81Minista RADIANT 10.12

DIPA Drug International 9.72RUPADIN Beacon 9.31Rosela Healthcare 8.10

Rupenta Orion Pharma 5.67Rupaday Eskayef Bangladesh Ltd. 3.64

Prescription Scenario

Ref: 4PMay’15[Product Share]

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Disease Profile

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Disease Profile

Seasonal & perennial allergic rhinitis

Chronic & acute urticariaPollinosisAllergic dermatitisAllergic conjunctivitis

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What is allergic rhinitis?

Ans.Allergic rhinitis is an inflammation of the tissues inside the nose. It causes sneezing, runny nose and stuffy nose. It is often accompanied by conjunctivitis (itchy, watery eyes). Most often it is caused by an allergy or an infection.

What is polinosis?

Ans.It is an allergy caused by pollen or dust in which the mucous membranes of the eyes and nose are itchy and inflamed, causing a runny nose and watery eyes.

What is urticaria ?Ans. Urticaria is a common debilitating skin disorder that is characterized by wheals, flare/erythema and pruritus, and is often accompanied by angio-edema. Historically, the etiology of the disorder has been poorly defined and this has led to it being referred to as chronic idiopathic urticaria in many instances.

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What is Allergic dermatitis ?Ans.It is a form of contact dermatitis that is the manifestation of an allergic response caused by contact with a substance

What is Allergic conjunctivitis?Ans.It is an inflammation of the conjunctiva (the membrane covering the white part of the eye) due to allergy

Treatment option

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Limitations & Opportunity

Allergic rhinitis or allergic symptoms (e.g. Nasal congestion, nasal rhinorrhea, nasal itching & sneezing attacks) require quick relief. But, all antihistamines are not able to show quick relief or rapid onset of action -

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To overcome this limitationOpso Saline introduces

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Brings back allergy free lively life 10 mg

tablet

At a glanceBrand Exalin TabletGeneric & strength Rupatadine 10 mg

Pack size 10x3Dosage form TabletJustification of brand name

Excellent allergic inhibition

Price 300 BDT /Pack; 10 BDT/ Unit

Pregnancy category • US FDA : C• TGA, Australia : B2

Nursing mothers: Benefit to risk ratioMajor indication Seasonal & perennial allergic rhinitis

Chronic & acute urticaria Pollinosis Allergic dermatitis Allergic conjunctivitis

Dose Once Daily 15

Promotional Support

•Literature•Gift •Sample*All promo items will be available before product launching

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Discussion on Literature

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Sir,in this visual you can see- a fielder is missed a catch due to lack of swiftness & promptness which may lead to loss the match.

Like that for the treatment of allergic symptoms require prompt acting Antihistamine(A fielder like Jonty Rhodes)

But, conventional antihistamine do not able to minimize allergic symptoms due to delayed onset

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01 02

03 04At a

glance

Target doctor & market ENTGPMedicinePCSurgeryOphthalmologist

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RUPARUPINMinistaDIPARUPADIN

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Some definitions for Rupatadine Mechanism of action

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What is Platelet-activating factor (PAF)?

Platelet-activating factor (PAF) is a lipid mediator that is well-known for its ability to cause platelet aggregation, inflammation, and allergic response. PAF is released by many different cells, including eosinophils, mast cells, neutrophils, monocytes, macrophages and endothelial cells.

What is eosinophil?Ans .Eosinophils are a type of disease-fighting white blood cell. High levels of eosinophils may also occur in your body's tissues at the site of an infection or inflammation (tissue eosinophilia).

What is chemotaxis?Ans.Movement of a cell toward or away from a chemical substance

What is CytokineAns.Molecule that controls reactions among cells; key component of inflammation

 What is NeutrophilAns.It is a type of leukocyte (white blood cell) that travels through the blood to an injured or inflamed site via a process called chemotaxis

What is Adhesion MoleculeAns.Any of a large number of cell-surface molecules of several different classes that affect the attachment of one cell to another

Thanks for your kind support

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