Post on 17-Jul-2020
Drug AddictionDrug Addiction
It’s All in Your BrainIt’s All in Your Brain
NIDA - Criteria for Substance Dependence DiagnosisNIDA - Criteria for Substance Dependence DiagnosisDiagnostic and Statistical Manual Diagnostic and Statistical Manual
A maladaptive pattern of substance use leading to clinicallyA maladaptive pattern of substance use leading to clinicallysignificant impairment or distress as manifested by three (orsignificant impairment or distress as manifested by three (ormore) of the following, occurring at any time in the same 12-more) of the following, occurring at any time in the same 12-month period:month period:
Substance is often taken in larger amounts or overSubstance is often taken in larger amounts or overlonger period than intended.longer period than intended.
Persistent desire or unsuccessful efforts to cut down orPersistent desire or unsuccessful efforts to cut down orcontrol substance use.control substance use.
A great deal of time is spent in activities necessary toA great deal of time is spent in activities necessary toobtain the substance e.g., visiting multiple doctors orobtain the substance e.g., visiting multiple doctors ordriving long distances), use the substance (e.g., chaindriving long distances), use the substance (e.g., chainsmoking), or recover from its effects.smoking), or recover from its effects.
Important social, occupational, or recreational activitiesImportant social, occupational, or recreational activitiesgiven up or reduced because of substance abuse.given up or reduced because of substance abuse.
NIDA - Criteria for Substance Dependence DiagnosisNIDA - Criteria for Substance Dependence DiagnosisDiagnostic and Statistical Manual Diagnostic and Statistical Manual
(continued)(continued)
Continued substance use despite knowledge of having aContinued substance use despite knowledge of having apersistent or recurrent psychological, or physical problempersistent or recurrent psychological, or physical problemthat is caused or exacerbated by use of the substance.that is caused or exacerbated by use of the substance.
Tolerance, as defined by either:Tolerance, as defined by either: need for increased amounts of the substance in order toneed for increased amounts of the substance in order to
achieve intoxication, desired effect; orachieve intoxication, desired effect; or markedly diminished effect with continued use of themarkedly diminished effect with continued use of the
same amountsame amount
Withdrawal, as manifested by either:Withdrawal, as manifested by either: characteristic withdrawal syndrome for the substance; orcharacteristic withdrawal syndrome for the substance; or the same (or closely related) substance is taken to relievethe same (or closely related) substance is taken to relieve
or avoid withdrawal symptomsor avoid withdrawal symptoms
Brain and Spinal CordBrain and Spinal Cord
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Image from The Virtual Hospital http://www.vh.org/Providers/Textbooks/BrainAnatomy/BrainAnatomy.html
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Image from The Virtual Hospital http://www.vh.org/Providers/Textbooks/BrainAnatomy/BrainAnatomy.html
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Image from The Virtual Hospital http://www.vh.org/Providers/Textbooks/BrainAnatomy/BrainAnatomy.html
impulse flowimpulse flow
The Reward PathwayThe Reward Pathway
The Reward PathwayThe Reward Pathway
Morphine Binding in Reward PathwayMorphine Binding in Reward Pathway
Opiate BindingOpiate Binding
Cocaine Dependence and the Reward PathwayCocaine Dependence and the Reward Pathway
Cocaine Binding SitesCocaine Binding Sites
Serotonin, LSD and EcstasySerotonin, LSD and Ecstasy
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Other Stuff (What Are PeopleOther Stuff (What Are PeopleThinking?)Thinking?)
Camel dungCamel dung C-4 explosiveC-4 explosive Embalming fluidEmbalming fluid Gasoline (“Montana Gin”)Gasoline (“Montana Gin”) M-99 (Immobilion)M-99 (Immobilion)
The Reward PathwayThe Reward Pathway
Morphine Tolerance Morphine Tolerance
thalamus
spinal cord
Morphine DependenceMorphine Dependence
thalamus
brainstem