Transcript of DR. PRADEEP DUBEY MD(PED). DCH. CONSULTANT PEDITRICIAN. DR. PRADEEP DUBEY MD(PED). DCH. CONSULTANT...
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- DR. PRADEEP DUBEY MD(PED). DCH. CONSULTANT PEDITRICIAN. DR.
PRADEEP DUBEY MD(PED). DCH. CONSULTANT PEDITRICIAN. VITAMIN D
DIFICIENCY IN CHILDREN AADIGURU NEURO PEDITRIC CENTRE PREM MANDIR
CHOWK, WRIGHT TOWN, JABALPUR.
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- 20 th century witnessed - Discovery of Vit D Nutrition
Research, Vol. 19, No. 11, pp. 1683-1718, 1999
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- The Evolution of Vit D Bone health Vitamin Miracle Drug For
strong bones
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- Vitamin D & Cancer J. Nutr. 135: 2739S2748S, 2005.
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- First evidence for anticancer effects of Vit D Biochem Biophys
Res Commun. 1981 Oct 15;102(3):937-43.
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- Clinical trials - Vit D & Cancer Ann Epidemiol
2009;19:468483.
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- Infections TB Epidemic influenza HIV Vaginal infections
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- Nobel Prize in Physiology or Medicine, 1903 Dr.Niels Ryberg
Finsen
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- Finsen extended his work to all forms of internal TB
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- Sputum Conversion Rate RCT Sputum conversion rates from AFB
positive to negative- Vit D 0.25 mg/day supplemented patients -100%
Non-supplemented patients- 77% South Med J. Author manuscript;
available in PMC 2010 November 1.
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- Refractory case of PTB- Improvement with Vit D
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- Vitamin D & Autoimmune diseases Who are you? Where am I?
You look delicious!
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- N Engl J Med 2007;357:266-81. J. Nutr. 135: 2739S2748S, 2005.
Multiple sclerosis IBDT1DM RA
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- Vit D deficiency- An Important, Common, & Easily Treatable
Cardiovascular Risk Factor?
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- PTH Diabetes & Metabolic Syndrome Hypertension &
Hypertrophy IR & Pancreatic cell dysfunction Inflammation RAAS
Atherosclerosis Adverse CV events J Am Coll Cardiol
2008;52:194956
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- Vitamin D deficiency in healthy South Indians Am J Clin Nutr
2007; 85: 1062-7 Deficient (
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- Vitamin D deficiency in healthy South Indians Am J Clin Nutr
2007; 85: 1062-7 Deficient (
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- Groups at Risk of Vitamin D Inadequacy Breastfed infants AAP
recommends that exclusively and partially breastfed infants be
supplemented with 400 IU of vitamin D per day Older adults Older
adults are at increased risk of developing vitamin D insufficiency
People with limited sun exposure Homebound individuals, people who
wear long robes and head coverings, & people with occupations
that limit sun exposure People with dark skin People with fat
malabsorption People who are obese or who have undergone gastric
bypass surgery
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- Cause of Rickets The First Insight
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- Vit D physiology N Engl J Med 2007;357:266-81.
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- RICKETS ROSARY
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- SKELETAL CHANGES
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- HEALING RICKETS
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- LINE OF CALCIFICATION
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- NORMAL PELVIS
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- DEFORMED PELVIS
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- Loading dose 60,000 IU/Week for 8 weeks 60,000 IU/Week for 8
weeks Blood test Maintenance dose 60,000 IU/ 60,000 IU/ Mont h Dose
of Vitamin D For treatment of Vitamin D Deficiency
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- Recommended Vitamin D Intake by Endo. Society Guidelines, 2011
Reasonable daily allowance (IU/ day) Reasonable allowance (IU/
month) 0-6 months400-100012000-30000 6-12 months400-100012000-30000
Children (1-18 yrs)1000-200030,000-60,000 Adults (19-50
yrs)1500-200045,000-60,000 Elderly (51-70
yrs)1500-200045,000-60,000 Elderly (71 yrs)1500-200045,000-60,000
Pregnancy1500-200045,000-60,000
Lactation1500-200045,000-60,000
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