Post on 12-Feb-2016
description
TUPDD0101:WILL A MULTIPLEX ASSAY DETECT NEW INFECTIONS OF HIV, SYP, HEP C AND B IN URBAN INDIA?
1. Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B
2. Feasibility of conduct3. Diagnostic accuracy4. Client preference
POPULATION
INTERVENTION SETTING
Hinduja National Hospital and Medical Research Center, and Sion Hospitals Mumbai, India
Point of care + combined counselling+
confirmatory testing STD Clinic attendees
Sion Hospital, Mumbai
OBJECTIVE
Mumbai Urban Poor
MiriadTM test on fingerstick blood
FLOW OF PARTICIPANTS
CATEGORY
SENSITIVITY
SPECIFICITY
REFERENCE STANDARDIndex test statusPRELIMINARY
POSITIVE
Index test statusPRELIMINARY
NEGATIVE
HIV 100% [95%, CI: 94.8,
100]
99.7% [95%, CI: 98.3,
99.9]
ELISA (antigen+antibody) +
Western BlotELISA
HBV 13.3% [95%, CI: 6.6, 23.2]
99.3% [95%, CI: 97.6,
99.9]
HBsAg + Total anti HBc + HBV DNA HBsAg + anti-HBc
HCV 50% [95%, CI: 1.26,
98.74]
99.7% [95%, CI: 98.5,
99.9]
HCV antibody + HCV RNA
Anti HCV screening test (EIA based)
Syphilis 86.1% [95%, CI: 70.5,
95.3]
85.2% [95%, CI: 80.9,
88.8]TRUST + TPHA TPHA
RESULTSDemographics
Gender 83% males
Age (mean) 31.2 years
Sample size375 STD Clinic
attendees
NITIKA PANT PAI, MD, MPH, PhDAssistant professor
McGill University, MontrealEmail: nitika.pai@mcgill.ca;
Co-investigators: Dr Anjali Shetty Hinduja Dr Rachita Dhurat, Sion