Death, Disease And DarwinDeath, Disease And Darwin

For a full transcript of the presentation,for which these slides were an accompaniment,

please visit:

https://sites.google.com/site/sjlewis55/presentations/sshb2009

Death, Disease and Darwin: Life in 3DThe individual and the fitness landscape

Stephen Lewis

(From Boorse (1987))

Evolutionary medicine is

“the enterprise of trying to find evolutionary explanations for vulnerabilities to disease”

(Randolph Nesse)

Physical State

Expe

rienti

al S

tate

[d]

[b][c]

[a]

(After Lewis (2009))

(From Wright (1932, 1988))

(Fig. 2 (Detail) - modified from Wright (1932, 1988))

G1G2

G3

G4

Fitness

Phenotype

Genotype

P1P2 P3

F1

F2

(After Stearns and Hoekstra (2005))

(Using Fig. 2 (Detail) (Wright 1932, 1988) as a Fitness Landscape)

Physical State

Expe

rienti

al S

tate

[d]

[c]

(After Lewis (2009))

(Using Fig. 2 (Detail) (Wright 1932, 1988) as a Fitness Landscape)

[d][c]

Death, Disease And DarwinDeath, Disease And Darwin

For a full transcript of the presentation,for which these slides were an accompaniment,

please visit:

https://sites.google.com/site/sjlewis55/presentations/sshb2009