Post on 15-Mar-2021
MIL ANO | ITALYIstituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com
D-CLARD-CLAR
INTENSIFIES THE EFFICACY OF PEELING/LASER TREATMENT FOR
HYPERPIGMENTATION
For physician use onlyFor physician use only
RILASTIL D-CLAR
A study on 2,823 adults (average age of 49 years) has highlighted that the prevalence of lentigo solaris is of 62,4%, while that of lentigo senilis is of 33,2%.*
*The Epidemiology of Nevi and Signs of Skin Aging in the Adult General Population: Results of the KORA-Survey 2000, T. Schafer et al., Journal of Investigative Dermatology (2006), Volume 126, 1490-1496
LENTIGO SOLARIS LENTIGO SENILIS POST-INFLAMMATORY HYPERPIGMENTATION
MELANIN CYCLE PHASES
PREVALENCE OF HYPERPIGMENTATION
The optimal topical treatment to contrast and prevent hyperpigmentation should act on every phase of the melanin cycle.
1st P
HA
SE
2nd
PH
AS
E3
rd P
HA
SE
4th P
HA
SE ACCUMULATION OF
MELANIN IN THE CORNEOCYTES OF THE STRATUM CONRNEUM
TRANSPORT OF THE MELANIN FROM
MELANOCYTE TO KERATINOCYTE
OXIDATION OF THE COLORLESS MELANIN INTO DARK MELANIN
SYNTHESIS OF THE MELANIN INSIDE THE
MELANOCYTE
UVB UVA
For physician use only
Dermofarm Laboratorios. Barcelona, January, 2020.
Instrumental evaluation of the melanin index (SkinColorCatch®).
RILASTIL D-CLAR
CLINICAL STUDIES
RILASTIL D-CLAR DEPIGMENTING CONCENTRATE DROPS
REDUCTION OF THE SPOT’S INTENSITY
Panel: 30 volunteers with hyperpigmentation on face, neck and neckline (24-45 years old).
Treatment: two localized applications (morning and evening) on the hyperpigmentation for 56 days.
For physician use onlyFor physician use only
Rilastil D-Clar Depigmenting Concentrate Drops determine a statistically significant reduction of the
spot’s intensity by 18,7% in 56 days.
-18,7% of melanin in 56 daysStatistically significant results p<0.0001
-18,7%
Mel
anin
Inde
x
500
650
620
590
560
530
T56T28T0
Cod: P00X55110
Dermofarm Laboratorios. Barcelona, July 3, 2019
Instrumental evaluation of the melanin index (SkinColorCatch®).
RILASTIL D-CLAR CONCENTRATED MICROPEELING
REDUCTION OF THE SPOT’S INTENSITY
Panel: 20 volunteers with hyperpigmentation on face, neck, neckline and back of hands (32-72 years old).Treatment: one application per day for 56 days.
RILASTIL D-CLAR
For physician use only For physician use only
Rilastil D-Clar Concentrated Micropeeling determines a statistically significant reduction of the spot’s intensity by 9% in 56 days.
-9% of melanin in 56 daysStatistically significant results p<0.0001
-9%
Mel
anin
Inde
x
540
620
600
580
560
T56T28T0
Dermofarm Laboratorios. Barcelona, June 28, 2019
Instrumental evaluation of the melanin index (SkinColorCatch®).
RILASTIL D-CLAR DAILY DEPIGMENTING CREAM
REDUCTION OF THE SPOT’S INTENSITY
Panel: 20 volunteers with hyperpigmentation on face, neck and neckline (27-69 years old).Treatment: two applications (morning and evening) on the whole area affected by the hyperpigmentation (face, neck, neckline) for 56 days.
Rilastil D-Clar Daily Depigmenting Cream determines a statistically significant reduction of the spot’s intensity by 10,8% in 56 days.
-10,8% of melanin in 56 daysStatistically significant results p<0.0001
-10,8%
Mel
anin
Inde
x
540
600
620
580
560
T56T28T0
Mandelic Acid
10%
anti-spot ingredients
5,2%
Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)
Depigmenting
Hyaluronic Acid Hydrating
Vitamin E Soothing
ACTIVE INGREDIENTS ACTIONS
Istituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com
ANTI-DARK SPOT TREATMENT
RILASTIL D-CLAR
40 ml
RILASTIL D-CLAR DAILY DEPIGMENTING CREAMDaily depigmenting, illuminating and uniforming treatment.
RILASTIL D-CLAR CONCENTRATED MICROPEELINGBiphasic milk with intensive exfoliating action.The texture with lipidic fraction restores the skin comfort.
100 ml
Mandelic Acid 10%Liposomal Tripeptide Exfoliating
Bisabolol Soothing
ACTIVE INGREDIENTS ACTIONS
For physician use only
Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)4-Butylresorchinol
Depigmenting
Fruit AHA Liposomal Tripeptide Exfoliating
Sodium DNA Elasticizing
Peony extract Soothing
ACTIVE INGREDIENTS ACTIONS
RILASTIL D-CLAR DEPIGMENTING CONCENTRATE DROPSLocalized depigmenting shock treatmentActive on every stage of the melanin cycle
ENHANCED FORMULA WITH HYDROXYRESVERATROL NIOSOME
anti-spot ingredients
13,7%
30 ml
1
2
3
Hydroxyresveratrol NiosomeClari-tech Complex (Tetrapeptide-30, High Tech Vitamin C, Niacinamide)
Depigmenting
Hyaluronic Acid Hydrating
Vitamin E Soothing Istituto Ganassini S.p.A. di Ricerche Biochimiche, Via P. Gaggia 16 - 20139 Milano - www.rilastil.com
RILASTIL D-CLAR
HOW TO USE
DEPIGMENTING CONCENTRATE
DROPS
MORNING
CONCENTRATED MICROPEELING
++DAILY
DEPIGMENTING CREAM
DEPIGMENTING CONCENTRATE
DROPS
+
For physician use onlyFor physician use only For physician use only
UNIFORMING AND DEPIGMENTING CREAM
SPF 50+
1 2 3
EVENING
0*Except for D-Clar Daily Depigmenting Cream
FRAGRANCE*WHEAT DERIVATIVES
Co
d: P
00
X55
110
- 0
220