Post on 07-Aug-2015
EVIDENCE SYNTHESIS TO HELP ENSURE SOUND POLICIES AND INVESTMENT
Paul Garner On behalf of the Cochrane infectious Diseases Group EditorsAnd the Effective Health Care Research Programme Consortium
Competing interests
Funded by the UK Aid Programme to increase the number of decisions based
on reliable evidence in health for the poor in developing countries
Thanks to everyone that helps, including
17 editors
Staff in LSTM
700 authors in 55 countries
Consortium partners
UK Aid
1993
500 authors
17 editors
12 staff
112 Systematic reviews
Systematic reviews of effects
• objectives
• methods (how trials are identified)
• apply inclusion criteria to trials
• extract predetermined outcomes
• contact authors for more data
Title Type
Bur Treatment of Buruli ulcer Intervention review ongoing
fil DEC salt for filariasis Intervention review publishedfil Albendazole for filariasis Intervention review Needs update
HAT
Chemotherapy for second-stage Human African
trypanosomiasis Intervention review published
HAT Community engagement in HAT Scoping review PHD/Staff
intestin
al
Deworming drugs for soil-transmitted intestinal
worms in children: effects on nutritional
indicators, haemoglobin and school performance Intervention review Being updated
NTD Wolbachia (scoping and Intervention) Intervention review open
Schisto Drugs for treating Schistosoma mansoni infection Intervention review published
Schisto Drugs for treating urinary schistosomiasis Intervention review published
Schisto
Circulating antigen tests and urine reagent strips
for diagnosis of active schistosomiasis in endemic
areas Diagnostic review in press
Schisto
Prophylactic drug interventions for
Schistosomiasis japonicum Intervention review ongoing
Schisto
Therapeutic drug interventions for
Schistosomiasis japonicum Intervention review ongoing
systems Mass Drug Administration User views ongoing
systems
Strategies for integrating PHC at the point of care
in LMIC Intervention review open
excluded: leishmania, headlice, dengue, neurocystercosis
Water and sanitation
• Water quality (in progress)
• Fecal disposal (in progress)
• Wash (in progress)
5 Cochrane authors: “it is probably misleading to justify contemporary deworming programmes based on evidence…”
Trial from 1999
Another one! completed 2004
Unpublished in 2013Devta in Hindi=“divine being”
Miguel and Kramer (Kenya) 2004trial used by Nobel Prize winners
“major, moderate and minor errors”
On re-analysis
• No between school effects
• No evidence of an effect on nutrition
• effect on school attendance preserved