CombiFlash Rf Torrent

For Large Scale

Purification

CombiFlash Rf Torrent Capabilities

■ Up to 1 L/min at 100 psi

■ 300g purifications in an hour unattended

■ Automatic solvent level sensing

■ Customize for different laboratory needs

■ All external tubing for easy loading

■ Collect known compounds using Time Windows

■ Compact design

Pumping System■ Level sensing on inlet and waste

■ Makes it a walk away large scale system

■ Pumps precisely from 0 to 100%■ Up to 1L/min accurately

■ Up to 100psi consistently

■ Accurately delivers DCM and MeOH

■ Solvent can be located on the floor

■ Up to 100 psi■ Large tubing creates minimal system backpressure

■ Custom inlets for variety of sources

Binary Gradient■ 2 Solvent inlet

■ B solvent auto prime for accurate gradients

■ 50ml/min to 1 L/min

■ 80 grams up to 3 kg columns purification■ 80 gram useful for method development and scale up

■ Rapid equilibration function

■ Fast air purge for column disposal

Customizable to Meet any Purification Need

Solvent Inlet Options

■ Stainless steel braided*

■ 5 (standard), 9 ft length

■ Grounded flow path

■ Pressurized solvent reservoirs*

■ Custom connection

■ Quick Connects

*Ability to have level sensing

Stainless Steel Braided

Remote Solvent Source

Pressurized Solvent Reservoirs

With Solvent Level Sensing

Optional Solvent Caps

■ 100 mm

■ 83B

■ Available for both inlet and outlet

■ Customize for your container

Injection Option 1■ Solid load cartridges

■ Cartridges available in 4 sizes■ 25, 65, 260, and 750 gram

■ Available empty and prepacked

■ Prepacked with silica, Celite or C18

■ Bulk silicas also available

■ Use cartridges as a guard column to extend the life of reusable columns

Injection Option 2■ Liquid Load pump

■ Pull directly from a sample container

■ Utilize an empty cartridge as a funnel, pull from the cartridge and load onto the column

■ Load manually with a syringe

Automatic Operation■ Injection valve enables true walk-

away automation

■ Automatically equilibrates, loads the sample and purifies

■ Post run - air purge, and clean the valve to ensure no cross contamination

Automatic Self Cleaning Injection Valve■ All external tubing

■ Easy to access and clean

■ Automatic wash sequence■ Wash injection valve with strong solvent after run

■ Prevents buildup in valve

■ Automatic operation■ “Start and walk away”

■ Rapid auto air purge

Detector Options■ Select from either internal UV or UV-Vis PDA detector

■ Peak collection via slope, threshold or time windows

■ Perform All-Wavelength Collection

■ Ability to detect small impurities in the sample

■ Alternatively, connect to an external detector

■ Teledyne Isco Model 340CF ELSD available

■ December software release will add Spectral Capabilities

■ December software release will add MS support/control

Torrent Collection Option 1■ Foxy R2 High Flow Fraction Collector

with RFID rack identification technology

■ Chain up to 4 collectors together

■ Collect in 16-25 mm test tubes or 450 ml bottles

■ Use funnel rack to collect unlimited quantities in any container

■ Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows

RFID Test Tubes Racks■ Greatest Collection Capacity – can be hot swapped

■ (150) 16x125 mm

■ (150) 16x150 mm

■ (140) 18x150 mm

■ (60) 25x150 mm

■ Bottle Racks – 480 ml■ 480 ml bottles available

■ Funnel Rack (36)■ RFID Rack Identification

■ Identifies rack sizes

■ Prevents overfilling or incorrect tube selection

Torrent Collection Option 2■ Torrent Fraction Valve

■ Collect up to 6 large volume fractions and a separate waste for defined protocols

■ Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows

■ Collect a given volume per container – up to 99 L

Torrent Collection Option 3

■ Manual collection – no collector necessary

■ Collect by hand

RediSep Rf and RediSep Rf Gold Columns■ RFID sensors for fast setup

■ Run 80 gram up to 3 kg columns

■ Scale up from an 80 gram

■ Scale up from the CombiFlash Rf+

■ 750g, 1.5 kg and 3 kg columns have large inlets and outlets to prevent flow restriction and crystallization

■ GOLD Speed and GOLD Resolution methods on RediSep Rf Gold silica columns

■ Save half the solvent

Teledyne Isco Confidential

21

The Real Driver to Sell a Torrent

■ Post Sales Revenue■ At the end of 2012 there were 70 Torrents in the field

■ Annually each Torrent used an average of:■ 750G RediSep 5■ 1500G RediSep 4■ 3000G RediSep 3■ 750G Gold 1■ 1500G Gold 2■ 3000G Gold 2

■ Over $9K in columns/instrument/year

Safety Features■ Vapor Sensors

■ Pressure Sensors

■ Air purge for easy disposal of columns

■ Audible alarm when user intervention is required

■ Removable, washable drain tray

■ Static-dissipative tubing throughout

■ Patented level sensing ensures adequate solvent for purification and prevents waste flow

■ Ability to network the system, watch progress, and make run adjustments from any location through either a PC or iPad

Teledyne Isco Confidential

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Key Markets

PharmaceuticalDrug Discovery Natural

Products

AgriculturalChemistry Foods

and Flavors

Petrochemicals