CHM-134 ORGANIC CHEMISTRY CHAPTER-11: AMINES

Transcript of CHM-134 ORGANIC CHEMISTRY CHAPTER-11: AMINES

CHM-134 ORGANIC CHEMISTRYCHAPTER-11: AMINES

Asst. Prof. Gülbin KURTAYFor more details please study: Organic Chemistry: Structure and Function Eighth Edition

K. Peter C. Vollhardt (Author), Neil E. Schore (Author) ISBN-10: 1319079458

Primary amines

Secondary amines Tertiary amines

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=K.+Peter+C.+Vollhardt&text=K.+Peter+C.+Vollhardt&sort=relevancerank&search-alias=books

https://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=Neil+E.+Schore&text=Neil+E.+Schore&sort=relevancerank&search-alias=books

10.1 NOMENCLATURE RULES

Substituent name: Amino-

4-(2-Aminoethyl)benzoic acid

Common names: Alkylamine

10.2 PHYSICAL PROPERTIES

1.Tetrahedral structure

2. Chiral amines racemize

10.2 PHYSICAL PROPERTIES

3. Basicity-Nucleophilicity

4. Weaker hydrogen bonds than OH

Less electronegative

than oxygen

NH3 b.p. –33.4 C

10.3 ACIDITY

Needs strong base

10.4 BASICITY

Reminder: The weaker the conjugate acid,

the higher its pKa and the stronger the corresponding base

10.5 SYNTHESIS OF AMINES

1. Alkylation of NH3, primary, and secondary amines

Overalkylation: Even though amine gets more hindered, it also gets more nucleophilic.One solution is to have excess of RNH2 and use RX as limiting reagents.

2. Via nitriles

3. Arenamine via nitroarene

4. Gabriel Synthesis

5. Reductive Amination

10.5 SYNTHESIS OF AMINES5. Reductive Amination

Primary amine

Secondary amine

Tertiary amine

10.5 SYNTHESIS OF AMINES6. Reduction of amides

7. Hofmann Rearrangement

10.6 REACTIONS OF AMINES

Hofmann Elimination

Reaction with Nitrous Acid (see the experiment video)

CHM-134 ORGANIC CHEMISTRY CHAPTER-11: AMINES

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