Chapter 20

DNA Replication and Repair

Replication is bidirectional

DNA Replication is Semidiscontinuous

Okazaki Fragments

DNA Polymerase III is a Multisubunit Enzyme

DNA Polymerase III Subunit Organization

DNA Replication

is a Processive Process.

Stages of DNA Replication

• Initiation•Elongation •Termination

PCNA analogous to E. coli b-subunit of E. coli DNA

polymerase

Repair of UV Induced Thymine

Dimers

General excision-repair

pathway

Repair of damage resulting from the

deamination of cytosine