Post on 03-Oct-2019
Challenges and Opportunities of the Italian Hub of Population Biobanks
The project for the construction of HIBP Elena Bravo
Department of Hematology, Oncology and Molecular Medicine (EOMM)
Istituto Superiore di Sanità
Pocchiari Aulditorium – March, 9th 2012
ISS - March, 9th 2012
PROJECT’S UNIT
OU 1 Coordination Unit Responsible Filippo Belardelli (EOMM, ISS). OU 2 Interoperability Unit Responsible Elena Bravo (EOMM, ISS). OU 3 Information technology Unit Responsible Paolo Roazzi (IT, ISS). OU 4 Population biobanks
OU 4 Population biobanks Biobank of the CNESPS (Centro Nazionale Epidemiologia Sorveglianza e Promozione della Salute, ISS) - Responsible Simona Giampaoli Biologic Bank of the EU Genetics of Healthy Ageing (GEHA) - Responsible Claudio Franceschi EURAC Biobank - Responsible Peter Pramstaller Banca Biologica del Progetto Moli-Sani (Moli-Sani) - Responsible Maria Benedetta Donati and Licia Iacoviello
ISS - March, 9th 2012
HIBP: Founding Partners (Study catalog) Biobank Name of project/study Acronym Collection
Target number of participants
Study design Status
EURAC, Bozen
Study of “microisolates” in South Tyrol MICROS 1300 Prevalenza Complete
Cooperative Health Research in South Tyrol CHRIS 15000 Cohort Starting
C.I.G. Interdepartmental Center L. Galvani – Univ of Bologna
Genetic of Healthy Ageing GEHA 7966 Cohort Complete
CNESPS (Centro Nazionale Epidemiologia Sorveglianza e Promozione della Salute, ISS, Rome )
Progetto Cuore CUORE
FINE 682 Cohort, cross-sectional prevalence Complete
MONICA 1785 Cohort, prevalence On going
MATISS 8512 Cohort, prevalence On going
OEC 1998 9712 Cohort, prevalence On going
OEC 2008 9020 Cohort, prevalence On going
Italian Twin Registry ITR No limit of enrollments Cohort, prevalence On going
Italian Project on the Epidemiology of Alzheimer's Disease
IPREA 4785 Cross-sectional and longitudinal follow-up Complete
MOLI-BANK, Molise The Moli-Sani Project
GENDIABE 900 Cohort Complete
IMA FAMILIES 752 Cohort Complete
IMMIDIET 2200 Cohort Complete
MOLISANI 25000 Cohort On going
WHY A NATIONAL NETWORK?
Researchers require large numbers of quality samples and datasets of genomic data combined with medical and personal information
Samples stored by population biobanks represent a great patrimony for preventive and predictive medicine and public health
Technology and genomics development are increasing the potentiality of already existing collections
The existing collections suffer from fragmentation, variable access rules and the lack of commonly applied standards and ethical procedures
ISS - March, 9th 2012
WHY A NATIONAL NETWORK? ( FOR POPULATION BIOBANKS)
• Several Italian collections are part of European and International projects
• p3g has an international catalogue of population biobanks project. Often only basic information are available
• In Italy, population-biobanks collections and work are less known than pathological biobanks and also reciprocal knowledge is poor
• Public resources are decreased. The medium-long term economical investment required for prospective population-based studies makes more difficult to implement prospective biobank-based studies
• Potential of harmonization and e-tools for integration of data have not been fully explored
ISS - March, 9th 2012
OBJECTIVES OF HIBP To stimulate integration of the population biobanks in the Italian
roadmap for scientific infrastructure and encourage synergic activities between public and private and Regions and Ministers
The recognition by policy makers of the value of population-based studies in improving public health and reducing health care spending
To promote population biobanks reciprocal knowledge and their activity in whole biobanking scientific community and epidemiologists
HIBP as a dynamic tool for preventive and predictive medicine in Italy To explore chances and develop /test methodologies to favor
collaboration and data integration by harmonization and e-tools
To work for future population-based studies to answer to the needs of harmonization standards for sample collection, storage, analysis and database infrastructure and to realize a common ethical and legal platform
To disseminate this work to facilitate participation to intra-regional, national, European and international collaborations
To align the goals of predictive and preventive medicine with the strategic objectives of the legal consortium of BBMRI
ISS - March, 9th 2012
ACTIVITIES (TO BUILD UP ON WHAT ALREADY EXISTS)
• HIBP: Meeting and very frequent contacts. Large discussion on the activities
• Implement collaboration with p3g (visit, webinar, share descriptive and scientific tools…)
• Create a common platform: www.iss.it/hibp
• Acquire more questionnaires by each collection, organize and publish the data
• Associate more partner ( section on website)
• To set a pilot project: give the «proof of concept» that «share» what exists provide supplementary epidemiological information
• Disseminate the work- Promote collaboration
ISS - March, 9th 2012
Founder Partners
Biobanche Study description form
Questionnaire description form
Physical and cognitive measures
DNA description form
IT description form
DNA details table
Biobanca del Centro Nazionale Epidemiologia Sorveglianza e Promozione della Salute (CNESPS)
Progetto CUORE
MONICA-LT (1983-)
FINE-IT (1985-2005)
MATISS (1984-)
OEC 1998 (1998-2002)
OEC-EHES (2008-2012)
Progetti IPREA e DEMENZE
Registro Nazionale Gemelli
EURAC
Study of "microisolates" in South Tyrol (MICROS)
Cooperative Health Research In South Tyrol (CHRIS)
Banca Biologica del EU Genetics of Healthy Ageing (GEHA)
MOLI-BANK
Moli-Sani
GENDIABE
IMA FAMILIES
IMMIDIET
ISS - March, 9th 2012
Questionnaires collection
Biobank Name of project/study Acronym
Target number of participants
Study design Status
Italian Network on Genetic Isolates (INGI)
Carlantino Project 1600 Cohort Case-control Ongoing
Genetic Park of Cilento Project No limit of
enrollments Cohort Case-control Ongoing
Genetic Park of Friuli-Venezia Giulia Project 2000 Cohort
Case-control Ongoing
Val Borbera Isolated Population Project VIPP No limit of
enrollments Cohort Case-control Complete
Istituto per lo Studio e la Prevenzione Oncologica (ISPO)
Florence section of European Prospective Investigation into Cancer and Nutrition
EPIC-Florence 13597 Cohort Ongoing
Biomarker Italung Study related to Lung BIP 1500 Clinical trial Ongoing
Cervical cancer Screening and HPV vaccines ITT study
1600 Clinical trial Ongoing
HIBP: Associate more partner Associate Partners (Study catalog)
ISS - March, 9th 2012
Associate Partners
Biobanche Study description form
Questionnaire description form
Physical and cognitive measures
DNA description form
IT description form
DNA details table
Italian Network on Genetic Isolates [INGI]
Carlantino Project
Genetic Park of Cilento Project
Genetic Park of Friuli-Venezia Giulia Project
Val Borbera Isolated Population Project [VIPP]
Istituto per lo Studio e la Prevenzione Oncologica [ISPO]
Florence section of European Prospective Investigation into Cancer and Nutrition [EPIC-Florence]
Biomarker Italung Study related to Lung Cancer [IBIP Italung Biomarkers Project]
Cervical cancer Screening and HPV vaccines ITT study
ISS - March, 9th 2012
Associate partners: questionnaires collection
A PILOT PROJECT FOR HIBP ( FOUNDER PARTNERS)
CCM funding do not support laboratory work for HIBP
General Scope : HIBP pilot study aims to test the synergism among collections to address (simple) scientific question of preventive medicine using available data
Specific AIM: To evaluate the correlation between lipidemic profile and geographical position of provenance.
Steps: To agree about scientific question that could be addressed Define the data that are needed to this aim Verify that the data are already available in the biobank To verify the accomplishment with ethical issues Open discussion and agreement on Data transfer agreement (DTA) Signature of DTA by all responsible of collections or unit Uploading of shared data To further test harmonization Statistical analysis of data Sharing results Diffusion of results
ISS - March, 9th 2012
Challenges and Opportunities of the Italian Hub of Population Biobanks
(HIBP) Istituto Superiore di Sanità (ISS)
in collaboration with CENTRO NAZIONALE PER LA PREVENZIONE
IL CONTROLLO DELLE MALATTIE (CCM) March 9th, 2012
Istituto Superiore di Sanità
Disseminate the work – Promote collaboration
Thank you
Mariarosaria Napolitano Filippo Santoro
Franca Moretti Maria Puopolo
Anna Ferrigno Ugo Visconti
Filippo Belardelli
OU.1 and OU.2 HIBP Partners p3G
and collaborators
Speakers and participants