Briefing to CCST

February 1, 2006

Dr. Leonard M. Napolitano, Jr.

Sandia National Laboratories

Livermore, CA

DOE’s Genomics:GTL ProgramA Protein Production and

Molecular Tag Facility for California

California has the opportunity to obtain federal funding for a next-generation biotech facility.

Facility would develop new technologies, processes, and materials to advance proteomics - the next life sciences frontier

Facility products and knowledge would anchor California’s expertise and prestige in this critical area

Because of proximity, California companies and researchers would be ideally positioned to benefit from this user facility

Allies and supporters that help develop the facility will have first-hand access to new knowledge

DOE’s Genomics:GTL Program aims to develop biological solutions to energy problems.

Proteomics is the next frontier in biological understanding and application.

DNA Proteins

the “blueprint” the tools

RNA

Biological pathways/cells:

the assembly lines and factories

DOE wants to build capital facilities to support their mission needs.

The first facility’s mission is to produce 1,000s of different proteins and their associated molecular affinity tags annually in research quantities

The facility will cost $200M and have a $40M annual operating budget

A proposal call is out with team formation, technical approach, and site selection as objectives

Proposal submission date is April 11, 2006

SNL, LLNL, and LBNL are forming a partnership to develop this facility.

Academic Allies

Other AlliesIndustrial Allies

LLNL

The Bay Area/I-80 Corridor is an outstanding location for this bioscience user facility.

SNL

SNL

11

22

3344

55

6677

88

99

Numbers - biotech centers ranked by sizeNumbers - biotech centers ranked by sizeDOE multiprogram national laboratories

LBNL

Industrial and academic partnering is crucial to the breakthroughs required for all phases of production.

Information/Computing/Process Control

Genes/Clones

Clones/Vectors

Reagents/Tags

Proteins

Sequence

Data

GeneSynthesis

ProteinPurification

ProteinProduction

Affinity ReagentProduction

ProteinCharacterization

Knowledge

Partners and users will benefit from both technology development and products.

The facility will provide an anchor for California’s competitive edge in biotechnology

The life sciences community will gain new methods, new products, and increased knowledge about proteins and related materials

The facility will establish standard protocols for making proteins and affinity reagents

Key additional benefits will include education outreach and entrepreneurial opportunities

We’re here to enlist your help.

Dr. Leonard M. Napolitano, Jr.Sandia National Laboratories, Livermore, CA(925) 294-3218, email: napolitano@sandia.gov

Articulation of the importance of bioscience infrastructure to the state

Identification of leveraging opportunities within the state to increase the economic and technological feasibility of the facility

Contact: