Post on 24-Sep-2020
BiopharmaceuticalFiltration Solutions
Lauter Filter.
Located in Hangzhou, 's plant covers a 2production workshop area of 6000 m , with 3000
2m area meeting the GMP requirements for 2 5manufacturing of medical devices, 600 m 10 -
2class cleaning room and 2400 m cleaning room.
We have more than twenty lines for the
production of microporous membranes and
pleated filter cartridges, advanced inspection
tools and equipments, as well as professional
R&D Center and Validation Center. All the
membrane products are manufactured in
ISO9001:2008 certified facility with the help of
trained manpower meeting or exceeding
industry standards.
COMPANY INTRODUCTION
icrofiltration is a well nown filtration leader,started from 1 , who focus on research and
de elopment o E lon, PES, PVDF, PTFE membrane, with pore size ranging from 0.03 μm to 10
μm, as well as design and production of arious pleated filter cartridges, s ringe filters and capsule
filters. pro ides professional assistances to li uid and ga ir filtration solutions for
customers around the world in biopharmaceutical, medical, foo e erage, microelectronic,
chemistr , water treatment and laborator pplications.
n biopharmaceutical industr , products
are used in highl egulated industries for critical
applications such as sterile filtration of
pharmaceutical and biopharmaceutical
process fluids, sterilit esting of aseptic drug
products, anal tical sample preparation, new
drug de elopment and so on.
has been ma ing great efforts to impro e
th ualit anagement s stem during the
process of obtaining the production certificates
and registration e help to deli er an e er
increasing portfolio of inno ati e products with
uni ue performance ad antages.
1 www.lauterfilter.com
Lauter
Lauter
Lauter
Lauter
Lauter
CONTENTS
COMPANY INTRODUCTION
CONTENTS
Lauter Membrane Technologies
Quality Assurance
Validation Service
Customer Support
Facilitie ater
el ultur edia Preparation
Small Volume Parenteral SVP
arge Volume Parenteral VP
Plasma Fractionation
phthalmic Solutions
Filter Cartridges
PS ow E tractable an onger Ser ic ife Filte artridge with Doubl a er PE embrane
13
1
1
1
1
3
1
3
Filter Housings
Connections
1
3
PS T ighl s mmetric PES Filter artridge fo igher Throughput Demands
PS V PES Filte artridge for Sterile
Filtration o igh Viscous Pharmac PS Singl a e drophilic PES Filter artridge for Final Filtration of Pharmac
PSD Doubl a e drophilic PES
Filte artridge for E tremelDemanding of Sterilizing Filtration PT drophobic PTFE Filter artridge wit roa hemica ompatibilit
PT drophobic PTFE Filter artridge for Sterilizing Filtration o ir as
P drophili lon Filter artridge for Sterile Filtration of
Facilitie ate P PT drophilic PTFE Filter artridge for Sol ent Filtration
P F lass Fiber Filte artridge
for Prefiltration of Viscous Pharmac nd Vaccines
drophili lo embrane
drophilic PE embrane
drophili embrane
drophobic PTF embrane
drophobic PVD embrane
Stainless Steel Filter ousing for Sanitar i uid
Filtration
Series
Stainless Steel Filter ousing fo as ir Filtration
Series
Sanitar isc olderSeries Filter
T Titanium Filte ousingSeries
Sanitar n lin i uid an as Filte ousing
Series
Chemical compatibility Guide
10
11
1
31
33
3
3
3
P drophili E Filter artridge for Prefiltration o iologicals
PV drophobic PVDF Filter artridge wit ow Protei inding
PP Th ost Economical PP
Filte artridge for Prefiltration PPF Th ost Efficient multi la er
PP Filte artridge for Prefiltration P P bsolute PP Filte artridge
fo cti e Pharmaceutica ngredients
1
3
3
3
3
3
Applications
Membranes
TP Tri lam apsule Filter for
Small Volum igh Value added Pharmac
os ar apsule Filter for Small Volum igh Value added Pharmac
P 1 P apsule Filter for Small Volum igh Value added Pharmac
F P φ 0 Filte nit®Easiprep φ
S ringe Filterφ13 φ 0/φ /φ33
3
1
Capsule Filters &Syring Filters
www.lauterfilter.com
Membrane Technologies
brings more than 26 years
experience in membrane technology to the
biopharmaceutical, medical, laboratory, food
& beverage, microelectronic and chemical
applications. And we have been continuously
working to provide customized filtration solutions
with high quality.
3
of
www.lauterfilter.com
membrane products are well designed with built-in quality assurance. We introduce the most stringent Quality
Management System covering careful selection of raw material, validated manufacturing process, quality control
and assurance and so on. All this is to ensure consistently offer high quality products for our customers.
Qu al i t y A s s u r ance
4
ISO Certified
Complete Traceability
Certificate of Products
Deep Characterization and Certification
Lauter
www.lauterfilter.com
I n t egr i t y T es tConfirm the correlation of integrity test values which
were gotten under both standard and process fluid
conditions.
B act er i al Chal l enge T es tAccording to ASTM F838 methodology, testify bacterial
retention capability of membrane or filter at a minimum 7 2concentration of 10 cfu/cm of filter surface area,
under simulated process conditions.
Chem i cal Com pat i bi l i t yEnsure the compatibility of filter and process fluid.
Ensure the reliability of filter in process condition.
Provide supportive data for filter selection.
E x t r act abl esDetermine all the chemical components that migrate
from membranes or filters into a drug product or process
fluid in proper solvents in worst case. It indicates
maximum possibility of chemical components migrating
from membranes or filters.
Ads or pt i onMeasure the adsorption ability of filter media in fluid
filtration process.
Mu l t i - u s e Val i dat i onConfirm retention capacity of cartridges in normal
process or simulated conditions after multiple uses.
F i l t er C l ean i ng
Provide the filter cleaning method for the specific fluid
filtration.
Sterilizing filtration for pharmaceutical liquids is indispensable and critically important in aseptic manufacturing. It is the
process of removing bioburden, particles and bacterial endotoxins from a fluid stream without adversely affecting drug
product quality. With years of experiences in pharmaceutical research, more details and supportive data were found
that the sterilizing filtration is a high risk process, whose risk is next only to that of sterilizing making and filling. Only if it gets
through with validation, we could be sure of the compatibility, extractables/leacheables and adsorption, then to confirm the
reliability of sterilizing filtration. Besides, GMP, FDA and PDA described the requirements for sterilizing filtration validation
under specific conditions.
can offer validation services, designed to the unique needs of each customer's fluid and set of process conditions,
and help to prepare normative documents to achieve regulatory compliance. These include the following items:
Validation Service
5
Lauter
www.lauterfilter.com
has always been working to support your
applications and welcomes the opportunity to assist
you in the education of your staff.
Cu s t om er S u ppor t
Cu s t om i z ed F i l t r at i on S ol u t i onsWe offer customized solutions for complex
filtration problems. And we will help you in finding
suitable solutions with minimizing filtration cost.
F i l t r at i on S y s t em D es i gn offers technical support for your selection of
filter materials, cartridge length, filter housing and
performing throughput studies to optimize filter sizing
with cost-effective filtration system.
I n s t al l at i on and Oper at i on T r ai n i ng filtration specialists are available to assist
customers with theory training and hands-on
installation and operation training.
T echn i cal S em i nar sTechnical seminars at customer’s location are
organized to help the users better understand
standard operation procedures of products, thus
to improve the performance and to extend the
service life of products. Besides, technical exchanges
can also be helpful for users to select the optimized
solutions for their applications.
6
offers an extensive range of support including
validation, filtration education, installation training,
and other experience sharing that customers need.
Lauter
Lauter
Lauter
Lauter
www.lauterfilter.com
Cells used to produce therapeutic proteins should have a precise nutritional balance to support their reproduction and growth. These nutrients are provided by culture media, which must be sterile. Final sterilizing filtration should assure the removal of bacteria and mycoplasma from culture media containing animal derived components.Culture media are then stored in a fermentation vessel or bioreactor after bulk preparation and sterilizing filtration. Prefilters are used to remove most particulate and colloidal contaminants from culture media in order to extend the service life of final sterilizing filters.
7
Cell Culture Media Preparation
� Prefiltration
Remove colloids, lipids and particles
� Sterilizing filtration
Remove bacteria and mycoplasma
Prefiltration should remove particulate and colloidal contaminants effectively and not hinder the bypass of important
components.
Prefilters must have high flow rates and consistent high throughputs in order to finish the separating process timely and
economically. Furthermore, the filtration system should be compatible with differences, resulting from batch to batch component variability.
Filtration Step Recommendation
Prefiltration LPM, LPGF
Sterile venting LPTA
Final filtration LPS, LPSD, LPSL
Prefiltration Sterile Filtration Sterile Holding Tank Final Filtration Bioreactor Fermentor
SterileVenting SterileVenting
Mix Tank
Media Powder
WFI
Separation Goals
Application Requirements
Recommendation
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8
Facilities Water
Pharmaceutical grade water is defined as feed water common to process systems such as washers, autoclavesor WFI systems. Since water source varies widely in quality, only appropriate filtration systems can ensure the production to be effective, safe and successful.Filtration is just one step of the manufacturing process of pharmaceutical grade water. Other steps may result in the increasing of particles, for both resin and activated carbon beds could produce powder.
Separation Goals Prefiltration
Remove colloidal and particulate contaminants to extend the service life of final filters.
Final Filtration
Remove particles, microorganisms and endotoxins to meet the requirements of FDA and other international standards.
Application RequirementsPrefilters must remove most particulate and colloidal contaminants effectively, and have high dirt-holding
capacity, and keep high flow rates and high throughputs.
Final filters must remove microorganisms and endotoxins, and keep high flow rates and high throughputs.
Filtration Step Recommendation
Prefiltration LPP, LPM, LPGF
Sterile venting LPTA
Final filtration LPSLPNN for removing endotoxins
Filters with positive charge have limited capacity of removing endotoxins. Once the capacity is saturated, they lose this ability of removing endotoxins. Series connection of two filters is the solution, monitoring the endotoxins between the two filters. When endotoxins exist in the downstream of the first f ilter, the second filter should replace the first one in its position. This can make full use of filters and ensure reliable retention rate. Replacement of filters with no charge depends on pre-setting limitation index such as maximum differential pressure, minimum flow rate and maximum life time.
Recommendation
Prefiltration Sterile Filtration Final FiltrationCompression
Air
Point of Use
Prefiltration Sterile Filtration Sterile Holding Tank Final Filtration
SterileVenting
Water
EndotoxinRemoval
Point of Use
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Large Volume Parenterals (LVP)
arge Volume Parenteral VPs re single unit doses more tha 0 cc. Prefiltration is used for remo ing particles to e tend the ser ice life of fina sterilizing iltration. Final filters are used for reducing bioburden or sterile filtration prior to terminal sterilization. Th olume o VPs is usuall ens of thousands of liters, and multiple filling lines ma e wor ing at the same time. ngredients in t pica VP solutions include water, de tros fro 0 , amino acid, salts an er iscous total
parenteral nutritio TP . Prefilters are used to reduce particles for salt solutions, and to remo e hard particles for de trose solutions before final sterilizing filtratio it s another option to reduce bioburden b sing 0. μm filters
9
� Prefiltration
emo e colloidal and particulate contaminants to e tend the ser ice life of downstream sterilizing filters
� Final filtration
educe bioburden prior to terminal sterilizatio 0. μm Sterile filtration prior to terminal sterilizatio 0. μm
VP filters must pro ide consistent high flow rates to ensure the accurac nd consistenc f filling.
Since t pica VP filling process is operated under high differential pressure and high flow rates, filters must ha e superior
mechanical strength and be reliable and robust.
The cost o VP filters must be economical.
Prefilters and sterilizing filters must bear multiple c cles of steam in place sterilization or hot water sanitization.
Filtration Step ecommendation
Prefiltration PP PPF
Steril enting PT
Final filtration PS
Separation Goals
Application Requirements
Recommendation
PrefiltrationSterile
olding Tan
Final Filtration
SterileVenting
i an
Powder
F
Filling utocla e Pac agingioburdeneduction
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10
Small Volume Parenterals (SVP)
Smal olume parenteral SVP nclud arious traditional and bioengineered drugs. These drugs are usuall ac aged in smal ial less tha 0 ml , pre filled s ringes and ampoules, or made in l ophilized powder ots of SVPs need aseptic processing for their lac f heat stabilit .Sterilizing filtration is used after s nthesis or before filling nd it can add the sterilit ssurance if sterilizing filtration is used at both locations. Prefilters should be used to reduce bioburden and particles, which would clog final filters prematurel .
Prefiltrationemo e colloidal and particulate contaminants to e tend the ser ice life of downstream sterilizing filters
Final filtration Pro ide a sterile filtrate meeting the re uirements of current regulator
Separation Goals
Final sterilizing filters should remo e bacteria without altering the effects of drug products. Therefore, these filters
should ha e low adsorption of acti e pharmaceutical ingredien P , low e tractables, be non p rogenic and integrit estable, and be sterile or can be sterilized.
Prefilters and final filters should ha e enough flow rates. Final filters in the filling machine must ha e strong structures
to pre ent media fle ing during pulsed flow filling processing, which will result in particle release, drips or other dispense problems.
Filtration Step ecommendation
Prefiltration PP P
Steril enting PT
Final filtration PS PSD
Application Requirements
Recommendation
Prefiltrationi an
SterileVenting
cti ePharmacetical
ngredients
Filling utocla e Pac agingFinal Filtration
therFormulation
ngredients
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Ophthalmic preparations, ranging from contact lens cleaning and storing solutions to washing solutions in eye surgery and eye treatment products, must meet the rigid regulatory requirements and product specifications. The major component of most ophthalmic solutions is water. Furthermore, there maybe salts such as NaCl, preventatives, vaseline for the production of ointments and gel polymer used for lubricants. Heat-sensitive ophthalmic solutions can be sterilized by sterilizing filtration or by adding sterilized components into pre-sterilized bulk solutions.
Ophthalmis Solutions
● Prefiltration Reduce particles and bioburden prior to sterilizing filtration
● Sterilizing filtration Keep reliable retention of microorganisms for a long time
● Filters must provide consistent high flow rates and be robust to satisfy mass manufacturing processes.
● Sterilizing filters must keep reliable retention of microorganisms for a long time.
● Filters must have no adsorption or binding of preservatives in product manufacturing.
Filtration Step Recommendation
Prefiltration LPP, LPM, LPGF
Sterile venting LPTA
Final filtration LPS, LPSD, LPSHV
Separation Goals
Application Requirements
Recommendation
PrefiltrationSterile Holding Tank
Final Filtration
SterileVenting
Mix Tank
Ingredients
WFI
FillingSterile Filtration
11 www.lauterfilter.com
12
Plasma Fractionation
Human plasma contains lots of valuable therapeutic proteins, such as albumin, a variety of immunoglobulins, V�
ófactors, fibrous proteins and other proteins. The process of extracting and purifying these proteins is called plasma fractionation. Plasma fractionation is accomplished by a series of extracting and purifying such proteins. Foreigners in plasma can result in instability of products and clogging of downstream filters. Therefore, prefilters are necessary for classification and removing impurities prior to chromatography and ultrafiltration. Final filters are used for the sterilizing filtration of heat-sensitive proteins.
● Prefiltration Remove colloids, aggregates, non-targeted proteins, lipids and particles to protect sterilizing filters or chromatography column prior to downstream purification.
● Sterilizing filtration Control the microorganism level during the manufacturing process. Final sterile filling (referred to SVPs)
● Prefiltration must remove contaminants and have no retention of target products.
● Filters must have consistent high flow rates and high throughputs for the sake of time and cost.
● Filters should not contaminate feeding liquids, especially metals such as aluminum.
Filtration Step Recommendation
Prefiltration LPM, LPGF, LPPF
Sterile venting LPTA
Final filtration LPS, LPSD, LPSHV
Separation Goals
Recommendation
Application Requirements
ClarificationPrecipitation
Plasma
PrefiltrationVirus Inactivation
SterileVenting
Concentration Final Filtration
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L P S L
LPSL filter cartridges are specially designed for sterilizing filtration of plasma fractionation, lyophilized powder and vaccines. They are featuring extremely low extractables with no more than 10mg/10”, longer service life with 40
cycles of SIP. These filters can powerfully ensure final product quality.
Appl icat ion
● Plasma Fractionation
● Lyophilized Powder
● Vaccines
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Double Layer Hydrophilic PES
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch40 inch
70mm
≥ ( ) per 10-inch cartridge2 20.46m 4.9ft
0.45+0.22
Forward: 4.2 bar @ 23� ; 1.5 bar @ 85�
Double layer hydrophilic PES Membrane
Low protein binding
Extensive drug compatibility for critical applications
Extremely low extractables
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
Water bubble point≥ 3500 mbar (50 psig)
Air diffusion ≤ 30ml/min/10”@2.8bar
Low Extractable and Longer Service Life Filter Cartridge with Double Layer PES Membrane
www.lauterfilter.com
≤ 10 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume , appendix C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/cm .
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
40 steam-in-place sterilization or autoclave cycles of 30 min at 123 .
Meets the criteria of Chinese Pharmacopoeia 2010, volume for purified water.
< 0.25 EU/ml as determined by the LAL test.
2
14
Biop
harm
ac
eutic
al
SL PES
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】
PP with stainlesssteel endcapB
【 】S
E
V
Silicone
LP D42 C 1 0 BS
【 】
EPDM
Viton
【 】
D42 (0.45+0.22)μm
【 】【 】
SL
【 】 【 【
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
(0.22+0.45)μ
0
50
100
150
200
250
300
20 30 40 50
PP with stainlesssteel liningC
PPA
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P S H T Highly Asymmetric PES Filter Cartridge for Higher Throughput Demands
LPSHT filter cartridges are integrity testable membrane filters, specially developed for terminal filtration needing highthroughputs, such as cell culture media, large volumeparenterals and vaccines applications. They are characterized by a unique highly asymmetric, hydrophilic polyethersulfone membrane, offering higher throughputs, low protein adsorption and superior microbiological safety.
Appl icat ion● Cell Culture Medium
● Large Volume Parenterals
● Vaccines
Specification
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Highly Asymmetric Hydrophilic PES
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
2≥ (5.7ft ) per 10-inch cartridge20.53m
0.1, 0.22, 0.45, 0.65, 0.8, 1.2, 3.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85
0.1 μm≥ 3800 mbar (55 psig)
0.22 m≥ 3400 mbar (49 psig)
0.45 m≥ 2300 mbar (33 psig)
Highly asymmetric, hydrophilic polyethersulfone
membrane
Absolute bacteria retention
Long service life and high flow rates
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
www.lauterfilter.com
16
SHT PES
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BS
【 】
EPDM
Viton
【 】
010
022
045
065
080
120
0.1 m
0.22 m
0.45 m
0.65 m
0.8 m
300
1.2 m
3.0 m
【 】【 】
SHT
【 】 【 【
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
7 21 x 10 CFU/cm .
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
Biop
harm
ac
eutic
al
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r) 0.1m
0
50
100
150
200
250
300
20 30 40 50
0.22 m
0.45 m
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P S H V PES Filter Cartridge for Sterile Filtration of High Viscous Pharmacy
LPSHV filter cartridges are designed for terminal filtration, specially for high viscosity liquids in biopharmaceutical industry,such as ophthalmic solutions, parenterals and vaccines. Because of high dirt holding capacity and low protein adsorption performance, these filters have longer service life for high viscosity pharmacy filtration.
Appl icat ion
Ophthalmic Solution
Parenterals with High Viscosity(Large Volume
Parenterals, Small Volume Parenterals)
Vaccines
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophilic PES
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ per 10-inch cartridge2 20.53m (5.7ft )
0.1, 0.22, 0.45, 0.65, 0.8, 1.2, 3.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85 ℃ ℃
0.1 μm≥ 3800 mbar (55 psig)
0.22 m≥ 3400 mbar (49 psig)
0.45 m≥ 2300 mbar (33 psig)
Low protein binding
Absolute bacteria retention
Long service life and high flow rates
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
www.lauterfilter.com
18
SHV PES
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BS
【 】
EPDM
Viton
【 】
010
022
045
065
080
120
0.1 m
0.22 m
0.45 m
0.65 m
0.8 m
300
1.2 m
3.0 m
【 】【 】
SHV
【 】 【 【
Biop
harm
ac
eutic
alPP with stainless
steel endcapB
PP with stainlesssteel liningC
PPA
@
10
6 0 0 cp Fluid Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r) 0.1m
0
100
200
300
400
500
600
20 30 40 50
0.22m
0.45m
µ µ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P S Single Layer Hydrophilic PES Filter Cartridge for Final Filtration of Pharmacy
LPS filter cartridges are integrity testable membrane filters specially developed for sterilizing filtration in biopharmaceutical industry. They are characterized by a unique asymmetric, hydrophilic polyethersulfone membrane, offering high throughputs, low protein adsorption and superior microbiological safety.
Appl icat ion
● Active Pharmaceutical Ingredient
● Cell Culture Medium
● Ophthalmic Solution
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Single Layer Hydrophilic PES
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ per 10-inch cartridge2 20.53m (5.7ft )
0.1, 0.22, 0.45, 0.65, 0.8, 1.2, 3.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85℃ ℃
0.1 μm≥ 3800 mbar (55 psig)
0.22 m≥ 3400 mbar (49 psig)
0.45 m≥ 2300 mbar (33 psig)
Low protein binding
Absolute bacteria retention
Long service life and high flow rates
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
Plasma Fractionation
Parenterals(Large Volume Parenterals, Small
Volume Parenterals)
Lyophilized Powder
Vaccines
www.lauterfilter.com
20
S PES
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BS
【 】
EPDM
Viton
【 】
010
022
045
065
080
120
0.1 m
0.22 m
0.45 m
0.65 m
0.8 m
300
1.2 m
3.0 m
【 】【 】
S
【 】 【 【
Biop
harm
ac
eutic
alPP with stainless
steel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r) 0.22m
0
50
100
150
200
250
300
20 30 40 50
0.45 m0.65 m
1.2 m
µ µ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P S D
LPSD filter cartridges are characterized by a unique highly asymmetric, double-layer hydrophilic polyethersulfone membrane, specially designed for extremely demanding of sterilizing filtration in biopharmaceutical industry. These filters can powerfully ensure products meeting the rigid requirements of current regulatory.
Appl i cat i on● Cell Culture Medium
● Ophthalmic Solution
● Plasma Fractionation
● Parenterals(Large Volume Parenterals, Small
Volume Parenterals)
● Lyophilized Powder
● Vaccines
S peci f i cat i on
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D i m ens i ons
F i l t r at i on A r ea
μ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Double Layer Hydrophilic PES
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40inch
68mm
≥ 0.44 per 10-inch cartridge2 2m (4.8ft )
0.22+0.1, 0.22+0.22, 0.45+0.22
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85 ℃ ℃
0. μm .1 μm≥ 000 mba sig
0. μm . μm≥ 3 00 mba 3 psig
0. μm . μm≥3 00 mba 0 psig
● Double la er h drophilic PES membrane
● ow protein binding and e tensi e drug
compatibilit or critical applications
● ntegrit estable
artridges produced in a controlled
en ironment
anufactured according t S 001 certified
ualit anagement S stem
Doubl a e drophilic PES Filte artridge for E tremel emanding of Sterilizing Filtration
www.lauterfilter.com
22
S PES
【 】【 】
0
10
0
30 30inch
0inch
10inch
D
Fin
Flat
Fin
Flat
D EE
【 】
inch
【 】【 】【 】S
E
V
Silicone
P D 1 0 S
【 】
EPD
Viton
【 】
D 1
D
D
0. 0.1μm
0. 0. μm
0. 0. μm
【 】【 】
S
【 】 【 【
iop
harm
ac
eutic
alPP with stainless
steel endcap
PP with stainlesssteel lining
PP
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
(0.2
2+0.
1)m
0
50
100
150
200
250
300
20 30 40 50
(0.22
+0.22)
m
(0.45+0.22) m
μ μ
≤ 0 mg per autocla ed 10 inch cartridge afte h soa n purified water at controlled room temperature.
eets the re uirements o hinese Pharmacopoeia 010, Volume Ⅱ, appendi Ⅸ .
eets the criteria fo non fiber releasing ilter as defined i F 10. b .
omponent materials mee T 1 33. 00 f hines ational Standard for Safet ests.
Passed the bacterial challenge testing using Brevundimonas diminuta T 1 1 t a minimum challenge concentration of
0 F .cm
00 ppb after a water flush o 0 liters per 10 inch cartridge.
1 team in place sterilization or autocla e c cles of 30 min at 1 3 ℃.
eets the criteria o hinese Pharmacopoei 010, olume Ⅱ for purified water.
. ml as determined b h est.
: PP < 0 ℃ (1 0℉): PP with stainless steel lined end cap < ℃ (1 ℉): PP with stainless steel lining < ℃ ( 03℉)
0 0inch
L P T Hydrophobic PTFE Filter Cartridge with Broad Chemical Compatibility
LPT filter cartridges are characterized by permanently hydrophobic PTFE membrane, specially developed for sterile filtration of Active Pharmaceutical Ingredients production. They are integrity testable, providing high throughputs, broad chemical compatibility and high flow rates. Due to their hydrophobic characteristic, they must be pre-wetted with ethanol or IPA before the filtration of aqueous solutions.
F eat u r es a n d B en ef i t s
● Broad chemical compatibility
● High throughputs and superior flow rates
● 100% integrity testable prior to release
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
EPDM/Viton/Silicone
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophobic PTFE
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.54 per 10-inch cartridge2 2m (5.8ft )
0.05 0.1, 0.22, 0.45, 1.0,3.0, , 5.0, 10
Forward: 4.2 bar @ 23 ℃; 1.5 bar @ 85 ℃
0.1 μm≥ 1000 mbar (14.5 psig)
0.22 m≥ 900 mbar (13 psig)
0.45 m≥ 300 mbar (4.35 psig)
Organic solvent filtration
Filtration for harsh chemicals and HPLC mobile
phases that destroy other membrane materials
Sterile filtration for aqueous media
Filtration for strongly corrosive or oxidizing solutions
www.lauterfilter.com
24
T HydrophobicPTFE
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BE
【 】
EPDM
Viton
【 】
010
022
045
100
300
500
0.1 m
0.22 m
0.45 m
1.0 m
3.0 m
01K
5.0 m
10 m
【 】【 】
T
【 】 【 【
Biop
harm
ac
eutic
al
Notes : T hey mus t be pre-wetted with ethanol or I PA before the fi ltration of aqueous s olutions .
005 0.05 m
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.1
m
0
50
100
150
200
250
300
20 30 40 50
0.22
m
0.45m
µ µ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
LPTA filter cartridges are featured by permanently hydrophobic PTFE membrane, specially designed for sterile venting and gas application in biopharmaceutical industry. They are integrity testable, offering the highest process security, high throughputs, extreme humidity and stringent in-line steam sterilizations
F eat u r es a n d B en ef i t s
High flow rates and low pressure drop
High strength, long service life and cost-effective
100% integrity testable prior to release
Have a particulate removal rating of 0.01 m in gases
and a microbial removal rating of 0.22 μm in liquids
μ
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
℃
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Double-layer Polytetrafluoroethylene (PTFE)
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ per 10-inch cartridge2 20.54m (5.8ft )
0.01
Forward: 4.2 bar @ 23 ℃; 1.5 bar @ 85 ℃
Bubble point≥ 1100 mbar with 60/40% IPA/water(15.95 psig)
HydroCorr (water intrusion test)≤ 0.75mL/min per 10-inch cartridge with water at 2620mbar
Hydrophobic PTFE Filter Cartridge for Sterilizing Filtration of Air/Gas
Sterile venting of vessels and carboys
Autoclave vacuum break lines
Fermentation air applications
Sterile process gases
Bioreactor inlet and outlet gas filtration
Sterile filtration of CO2
www.lauterfilter.com
TA HydrophobicPTFE for air
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
LP 001 C 1 0
【 】【 】【 】
TA
【 】 【 【
≤ 10 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
200 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
< 0.25 EU/ml as determined by the LAL test.
001 0.01μm
26
【 】【 】【 】S
E
V
Silicone
BS
【 】
EPDM
Viton
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Biop
harm
ac
eutic
al
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
303Nitrogen Flow Rate(m /h/10")
Diff
eren
tial P
ress
ure(
mba
r)
0 bar outlet pressure
0
50
100
150
200
250
300
60 90 120 150
2 bar outlet pressure
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.lauterfilter.com
L P NN Hydrophilic Nylon Filter Cartridge for Sterile Filtration of Facilities Water & API
LPNN filter cartridges are characterized by hydrophilic Nylon membrane, providing high throughputs, low extractables and good mechanical strength, widely used for sterile filtration in Active Pharmaceutical Ingredients production and facilities water, for removing particles, microorganisms and endotoxins to meet the requirements of FDA and other international standards.
F eat u r es a n d B en ef i t s● Low extractables and high absorption
● High throughputs and superior flow rates
● 100% integrity testable prior to release
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophilic Nylon
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ per 10-inch cartridge2 20.59m (6.4ft )
0.1, 0.22, 0.45, 0.65, 1.0, 3.0, 5.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85 ℃ ℃
0.22 m≥ 2800 mbar (40.6 psig)
0.45 m≥ 1200 mbar (17.4 psig)
Facilities water
Active pharmaceutical ingredients
28
NN Nylon
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BE
【 】
EPDM
Viton
【 】
010
022
045
100
300
500
0.1 m
0.22 m
0.45 m
1.0 m
3.0 m
5.0 m
【 】【 】
NN
【 】 【 【
Biop
harm
ac
eutic
al
065 0.65 m
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.45
m
0
50
100
150
200
250
300
20 30 40 50
0.22
m
1.0 m3.0 m
µ µ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P T L Hydrophilic PTFE Filter Cartridge for Solvent Filtration
LPTL filter cartridges are characterized by hydrophilic PTFE membrane and polypropylene components for broad applications, widely used in Active Pharmaceutical Ingredients production in a variety of solvent filtration.
F eat u r es a n d B en ef i t s
● Broad chemical compatibility
● No need of pre-wetting
● 100% integrity testable prior to release
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Membrane
Thermal Bonding, No Adhesives
Viton/EPDM/Silicone
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophilic Polytetrafluoroethylene (PTFE)
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.54 per 10-inch cartridge2 2m (5.8ft )
0.1, 0.22, 0.45, 1.0
Forward: 4.2 bar @ 23℃; 1.5 bar @ 85℃
0.1 m≥1100 mbar (16 psig)
0.22 m≥ 900 mbar (13 psig)
Organic solvent filtration
Filtration for harsh chemicals
Sterile filtration for aqueous media
Filtration for strongly corrosive or oxidizing solutions
www.lauterfilter.com
30
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 022 C 1 0 BE
【 】
EPDM
Viton
【 】
010
022
045
100
0.1 m
0.22 m
0.45 m
1.0 m
【 】【 】
TL
【 】 【 【
Biop
harm
ac
eutic
al
TL HydrophilicPTFE
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.1
m
0
50
100
150
200
250
300
20 30 40 50
0.22
m
0.45m
μ μ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.anowfilter.com31
L P M Hydrophilic MCE Filter Cartridge for Prefiltration of Biologicals
LPM filter cartridges are characterized by high-performance, hydrophilic mixed cellulose esters membrane, offering high flow rates, low protein adsorption and superior microbiological safety. These filters are designed to reduce costs and are especially suited for prefiltration of vaccines and plasma fractionation production.
F e a t u r e s a n d B e n e f i t s
● Low protein binding
● Superior throughputs and cost-effective
● High retention efficiency for more critical
degrees of prefiltration
Q u a l i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S p e c i f i c a t i o n
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D i m e n s i o n s
F i l t r a t i o n A r e a
μ
Membrane
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophilic MCE
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.59 per 10-inch cartridge2 2m (6.4ft )
0.1, 0.22, 0.45, 0.65, 1.0, 3.0, 5.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85 ℃ ℃
Vaccines
Plasma Fractionation
0.22 m≥1000 mbar (14.5 psig)
0.45 m≥ 500 mbar (7.25 psig)
31 www.lauterfilter.com
32
M MCE
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 045 C 1 0 BS
【 】
EPDM
Viton
【 】
010
022
045
100
300
500
0.1 m
0.22 m
0.45 m
1.0 m
3.0 m
5.0 m
【 】【 】
M
【 】 【 【
Biop
harm
ac
eutic
al
065 0.65 m
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.1m
0
50
100
150
200
250
300
20 30 40 50
0.22
m0.45 m
μ μ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
L P V Hydrophobic PVDF Filter Cartridge with Low Protein Binding
LPV filter cartridges are characterized by hydrophobic PVDF membrane and polypropylene components, featuring lowestprotein binding. Due to these characterizes, they are ideal for sterile filtration of biologicals, chemical intermediates and organic solvents.
F eat u r es a nd B enef i t s● Minimum protein binding and low extractables
● Broad chemical compatibility
● Superior throughputs and high flow rates
● 100% integrity testable prior to release
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f i cat i on
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D i m ens i ons
F i l t r at i on A r ea
μ
Membrane
Thermal Bonding, No Adhesives
Silicone/Viton/EPDM
PP (222/226 with encapsulated stainless steel reinforcing ring)
PP
PP
Hydrophobic PVDF
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.59 per 10-inch cartridge2 2m (6.4ft )
0.1, 0.22, 0.45, 0.65, 1.0, 3.0, 5.0
Forward: 4.2 bar @ 23℃; 1.5 bar @ 85℃
0.1 m≥ 400 mbar (5.8 psig)
0.22 m≥ 300 mbar (4.35 psig)
Biologicals
Chemical intermediates
Organic solvents
33 www.lauterfilter.com
34
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
【 】【 】【 】S
E
V
Silicone
LP 045 C 1 0 BE
【 】
EPDM
Viton
【 】
010
022
045
100
0.1 m
0.22 m
0.45 m
1.0 m
【 】【 】
V
【 】【 【
Biop
harm
ac
eutic
al
V HydrophobicPVDF
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
300 3.0 m
500 5.0 m
065 0.65 m
2
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r) 0.1m
0
50
100
150
200
250
300
4 6 8 10
0.22 m0.45 m
μ μ
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
Meets the requirements of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.
Meets the criteria for a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration of
71 x 10 CFU/ .2cm
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
15 steam-in-place sterilization or autoclave cycles of 30 min at 123 ℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
< 0.25 EU/ml as determined by the LAL test.
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
LPP filter cartridges are constructed of polypropylene fine fiber, featuring high flow rates and high dirt holding capacity. They are the most economical and efficient prefilters in biopharmaceutical industry, removing most particulate and colloidal contaminants. These filters can be personalized according to your specific fluids and processes, such as pore size and other characteristics, improving filtration efficiency and reducing filtration costs.
F eat u r es a n d B en ef i t s
● Superior dirt-holding capacity
● High flow rates
● Broad chemical compatibility
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
Speci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Filter Media
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP
PP
PP
PP
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.41 per 10-inch cartridge2 2m (4.4ft )
0.1, 0.22, 0.45, 0.65, 1.0, 3.0, 5.0, 10, 20
Forward: 4.2 bar @ 23℃; 1.5 bar @ 85℃
The Most Economical PP Filter Cartridge for Prefiltration
Active Pharmaceutical Ingredient
Cell Culture Medium
Ophthalmic Solution
Parenterals(Large Volume Parenterals, Small
Volume Parenterals)
Lyophilized Powder
Vaccines
Plasma Fractionation
35 www.lauterfilter.com
P PP
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
LP 100 C 1 0
【 】【 】【 】
P
【 】 【 【
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
Support steam-in-place sterilization or autoclave at 123℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
【 】【 】【 】S
E
V
Silicone
AS
【 】
EPDM
Viton
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
≥ 80
Biop
harm
ac
eutic
al
< 0.25 EU/ml as determined by the LAL test.
010
022
045
100
300
500
0.1μm
0.22μm
0.45μm
1.0μm
3.0μm
5.0μm
065 0.65μm
01K
02K
10μm
20μm
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r) 3.0 m
0
50
100
150
200
250
300
20 30 40 50
0.22 m0.45 m
1.0 m
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.anowfilter.com37
LPPF filter cartridges are constructed of multilayer polypropylene, featuring high flow rates, broad chemical compatibility and high dirt holding capacity. These filters are ideal for prefiltration in biopharmaceutical industry, removing particulate and colloidal contaminants. And these cartridges can be personalized according to your specific filtration fluids and processes, improving filtration efficiency and reducing filtration costs.
F eat u r es a n d B en ef i t s
● Superior dirt-holding capacity
● Reliable retention of particulates
● Broad chemical compatibility
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Filter Media
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP
PP
PP
Multi-layer PP
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
2 20.2~0.3 m (2.1~3.2 ft ) per 10-inch element
0.5, 1.0, 3.0, 5.0, 10, 20
Forward: 4.2 bar @ 23 ℃; 1.5 bar @ 85 ℃
The Most Efficient multi-layer PP Filter Cartridge for Prefiltration
Active Pharmaceutical Ingredients
Cell Culture Medium
Ophthalmic Solution
Parenterals(Large Volume Parenterals, Small
Volume Parenterals)
Lyophilized Powder
Vaccines
Plasma Fractionation
37 www.lauterfilter.com
PF Multi-layer PP
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
LP 100 C 1 0
【 】【 】【 】
PF
【 】 【 【
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
Support steam-in-place sterilization or autoclave at 123℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
【 】【 】【 】S
E
V
Silicone
AS
【 】
EPDM
Viton
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
≥ 90
Biop
harm
ac
eutic
al
< 0.25 EU/ml as determined by the LAL test.
100
300
500
1.0μm
3.0μm
5.0μm
050 0.5μm
01K
02K
10μm
20μm
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.5m
0
50
100
150
200
250
300
20 30 40 50
1.0m
3.0m
5.0m
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.anowfilter.com39
LPAP absolute filter cartridges are constructed of polypropylene fine fiber, featuring high flow rates, high dirt holding capacity and reliable particle removal efficiency. Due to their features, they are the most economical and efficient prefilter cartridges, ideal for the wide range of classification and prefiltration in Biopharmaceutical Industry, especially in Active Pharmaceutical Ingredients Manufacturing.
F eat u r es a nd B enef i t s● Superior dirt-holding capacity
● Broad chemical compatibility
● Low extractables and low protein binding
● Reliable retention of particulates
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f i cat i on
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D i m ens i ons
F i l t r at i on A r ea
μ
Filter Media
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP
PP
PP
Absolute PP
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
2 20.2~0.3 m (2.1~3.2 ft ) per 10-inch element
0.5, 1.0, 3.0, 5.0, 10, 20
Forward: 4.2 bar @ 23 ℃; 1.5 bar @ 85℃
Absolute PP Filter Cartridge for Active Pharmaceutical Ingredients
parenterals, organic solvents, DIW
Clarification
Prefiltration for air & gas
Prefiltration for chemical intermediates, biologicals,
39 www.lauterfilter.com
AP PP
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
LP 100 C 1 0
【 】【 】【 】
AP
【 】 【 【
40
【 】【 】【 】S
E
V
Silicone
AS
【 】
EPDM
Viton
Biop
harm
ac
eutic
al
100
300
500
1.0μm
3.0μm
5.0μm
050 0.5μm
01K
02K
10μm
20μm
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
Support steam-in-place sterilization or autoclave at 123℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
≥ 95
< 0.25 EU/ml as determined by the LAL test.
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.5m
0
50
100
150
200
250
300
20 30 40 50
1.0m
3.0m
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.anowfilter.com41
LFGF filter cartridges are adsorption depth filters, designed for removing colloidal and viscous contaminants in vaccines and culture media. Featured by high dirt holding capacity and excellent particle retention ability, these filters can effectively protect the final cartridges to extend the service life.
F eat u r es a n d B en ef i t s
● High throughputs and high adsorption
● Superior dirt-holding capacity
● Reliable retention of particulates
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support
Core, Cage and Drainage
End Caps
O-rings/Gasket
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Filter Media
Thermal Bonding, No Adhesives
Silicone/EPDM/Viton
PP
PP
PP
Glass Fiber
Diameter
Length5 inch, 10 inch, 20 inch, 30 inch, 40 inch
68mm
≥ 0.37 per 10-inch element2 2m (4.0ft )
0.45, 1.0, 3.0, 5.0
Forward: 4.2 bar @ 23 ; 1.5 bar @ 85 ℃ ℃
Vaccines
Culture Media
Colloidal and viscous liquids
Glass Fiber Filter Cartridge for Prefiltration of Viscous Pharmacy and Vaccines
41 www.lauterfilter.com
GF Glass Fiber
【 】【 】
05
10
20
30
40 40inch
30inch
20inch
10inch
A
B
C
D
222/Fin
222/Flat
226/Fin
226/Flat
DOEE
【 】
5inch
LP 045 C 1 0
【 】【 】【 】
GF
【 】 【 【
≤ 50 mg per autoclaved 10-inch cartridge after 24-h soak in purified water at controlled room temperature.
< 500 ppb after a water flush of 60 liters per 10-inch cartridge.
Support steam-in-place sterilization or autoclave at 123℃.
Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.
【 】【 】【 】S
E
V
Silicone
AS
【 】
EPDM
Viton
Component materials meet GB/T 14233.2<2005> of Chinese National Standard for Safety Tests.
≥ 95
Biop
harm
ac
eutic
al
< 0.25 EU/ml as determined by the LAL test.
100
300
500
1.0μm
3.0μm
5.0μm
045 0.45μm
PP with stainlesssteel endcapB
PP with stainlesssteel liningC
PPA
@
10
Water Flow Rate(L/min/10")
Diff
eren
tial P
ress
ure(
mba
r)
0.45 m
0
50
100
150
200
250
300
20 30 40 50
1.0 m
A: PP <60 ℃ (140℉)B: PP with stainless steel lined end cap <85℃ (185℉)C: PP with stainless steel lining <95℃ (203℉)
www.anowfilter.com43
CTP Tri-Clamp capsule filters are designed to provide smart, disposable and safe filtration for small capacity liquids of lyophilized powder and other pharmacy. These disposable filters can help eliminate cleaning problems and extra validation costs. The T-style configuration isideal for operation. 100% integrity testable prior to release ensures high quality products.
F eat u r es a n d B en ef i t s
● Eco-friendly and cost-effective
● Smart, disposable and safe
● Low hold-up volume
● Good resistance to pressure
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support & Housing
Sealing Technology
F i l t r at ion A r ea
µ
Filter Media
Thermal Bonding, No Adhesives
PP
PES/Nylon/PTFE/PP/GF/PVDF/MCE
≥ 0.2 2 2m (2.2ft )
Please refer to Ordering Information.
Liquid: 3.5 bar @ 23℃ and 3.0 bar @ 60℃
Tri-Clamp Capsule Filter for Small Volume & High Value-added Pharmacy
Air&Gas: 3.0 bar @ 23℃ and 2.5 bar @ 60℃
. 0 1 µ m , 0 .1 µ m , 0 .2 2 µ m P E S / P T F E
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration
7 2of 1 x 10 CFU/cm .
S
3 autoclave cycles of 30 min at 123 ℃; steam-in-place sterilization not recommended.
For more information on specification, please refer to cartridges with the same membrane.
43 www.lauterfilter.com
m
S PES FS
FE
5inch
CTP 010 FS 5S
Biop
harm
ac
eutic
al
010
022
0.1μm
0.22μm
001 0.01( for air)
μm
NN Nylon
TL HydrophilicPTFE
TA HydrophobicPTFE for Air
T HydrophobicPTFE
P PP
GF Glass Fiber
V HydrophobicPVDF
100 1.0μm
045 0.45μm
300 3.0μm
5
207
82.5
5
1"TC
mm
Inlet/Outlet: Tri-clampVent&Drain: Silicone
Inlet/Outlet: Tri-clampVent&Drain: EPDM
500 5.0μm
M MCE
T F 2
300
250
200
150
100
50
0 0.4 0.8 1.2 1.6 2.0
Diff
eren
tial P
ress
ure(
mba
r)
( / )
300
250
200
150
100
50
0 0.5 1.0 1.5 2.0 2.5
Diff
eren
tial P
ress
ure(
mba
r)
( / )
P P P T FE
. μ
.μ
.μ
.μ
. μ. μ
www.anowfilter.com45
CHP Hose Barb capsule filters are designed to provide smart, disposable and safe filtration for small volume liquid and high value-added liquid of lyophilized powder and other pharmacy. Disposable filters can help eliminate cleaning problems and extra validation costs. 100% integrity testable prior to release ensures high quality products.
F eat u r es a n d B en ef i t s
● Eco-friendly and cost-effective
● Smart, disposable and safe
● Low hold-up volume
● Good resistance to pressure
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support & Housing
Sealing Technology
F i l t r at ion A r ea
µ
Filter Media
Thermal Bonding, No Adhesives
PP
PES/Nylon/PTFE/PP/MCE/PVDF/GF
≥ 0.2 2 2m (2.2ft )
Please refer to Ordering Information.
Liquid: 3.5 bar @ 23℃ and 3.0 bar @ 60℃
Hose Barb Capsule Filter for Small Volume & High Value-added Pharmacy
Air&Gas: 3.0 bar @ 23℃ and 2.5 bar @ 60℃
. 0 1 µ m , 0 .1 µ m ,
0 .2 2 µ m P E S / P T F E
Passed the bacterial challenge testing using Brevundimonas diminuta(ATCC19146) at a minimum challenge concentration
7 2 of 1 x 10 CFU/cm .
S
3 autoclave cycles of 30 min at 123 ℃; steam-in-place sterilization not recommended.
For more information on specification, please refer to cartridges with the same membrane.
45 www.lauterfilter.com
m
S PES DS
DE
5inch
CHP 022 DS 5S
Biop
harm
ac
eutic
al
010
022
0.1μm
0.22μm
001 0.01( for air)
μm
NN Nylon
TL HydrophilicPTFE
TA HydrophobicPTFE for Air
T HydrophobicPTFE
P PPGF Glass Fiber
V HydrophobicPVDF
100 1.0μm
045 0.45μm
5
FLOW
Hose barb 13.6mm
7.5
189
166
70
mm
mm
Inlet/Outlet: 13.6mmVent/Drain: 7.5mmWith Silicone
Inlet/Outlet: 13.6mmVent/Drain: 7.5mmWith EPDM
300 3.0μm
500 5.0μm
M MCE
T F 2
300
250
200
150
100
50
0 0.4 0.8 1.2 1.6 2.0
Diff
eren
tial P
ress
ure(
mba
r)
( / )
300
250
200
150
100
50
0 0.5 1.0 1.5 2.0 2.5
Diff
eren
tial P
ress
ure(
mba
r)
( / )
P P P T FE
. μ
.μ
.μ
.μ
. μ. μ
www.anowfilter.com47
F eat u r es a n d B en ef i t s
Qu al i t y
Cartridges produced in a controlled
environment
Manufactured according to ISO9001 certified
Quality Management System
S peci f icat ion
Support & Housing
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
µ
Thermal Bonding, No Adhesives
PP
Length
Inlet/Outlet Please refer to Ordering Information
2.5”, 5”, 10”
● Compact and sturdy construction
● Disposable design, easy change-out
● High pressure resistance
1/4" NPT Capsule Filter for Small Volume & High Value-added Pharmacy
Vent/Drainage Please refer to Ordering Information
2. 5- inch
5-inch
10-inch
≥ ( )2 20.1m 1. 1ft
Please refer to Ordering Information.
Liquid: 3.5 bar 23℃, 3.0 bar @ 60℃ @
≥ ( )2 20.2m 2. 2ft
≥ ( )2 20.3m 3. 4ft
Air&Gas: 3.0 bar 23℃, 2.5 bar @ 60℃ @
PES/Nylon/PTFE/PP/GF/PVDF
CNP 1/4"NPT capsule filters are designed to provide smart, disposable and safe filtration for small volume liquid and high value-added pharmacy. Disposable filters can help eliminate cleaning problems and extra validation costs. 100% integrity testable prior to release ensures high quality products.
For more information on specification, please refer to cartridges with the same membrane.
Filter Media
47 www.lauterfilter.com
【 】【 】
2
5
9 10inch
5inch
【 】
2.5inch
CNP 022 B 2
【 】【 】【 】
S
【 】
F i l ter 【 【
Biop
harm
ac
eutic
al
@
300
250
200
150
100
50
0 0.2 0.4 0.6 0.8 1.0
.μ
Diff
eren
tial P
ress
ure(
mba
r)
( / / . )
300
250
200
150
100
50
0 0.5 1.0 1.5 2.0 2.5
Diff
eren
tial P
ress
ure(
mba
r)
( / / . )
P P P T FE
Inlet/Outlet:1/4"MNPTBVent/Drain: 1/8"MNPT
B type connectionH type for pipe threadconnection adapterSilicone O-ring
BHS
B type connectionH type for pipe threadconnection adapter
O-ringEPDM
BHE
010022
0.1μm 0.22μm
100
045
1.0μm
0.45μm
300
500
3.0μm
5.0μm
0010.01(for air)
μmS PES
NN Nylon
Absolute PP
TL Hydrophilic PTFE
T Hydrophobic PTFE
V Hydrophobic PVDF
P PP
TA Hydrophobic PTFE for air
Multi-layer PPPF
AP
GF Glass Fiber
MCEM
NPT1/4"
Ø67
112
-
4529
Ø6
Ø9.3
FLOW
FLOW
Ø67 Ø67
NPT1/4" NPT1/4"
201
296
FLOW
Unit: mm
.μ
.μ . μ
. μ . μ
www.anowfilter.com49
F5P filters have good pressure resistance up to 350kpa,2with filtration area of nearly 20 cm .They have high
throughputs under low pressure drops, and can be
reusable after autoclaved. F5P are designed to connect
easily to hose barbs, as well as 6:100 luer slip.
F eat u r es a n d B en ef i t s
Qu al i t y
S peci f icat ion
Support & Housing
Sealing Technology
D im en s ion s
F i l t r at ion A r ea
m , µ m
Filter Media
Thermal Bonding, No Adhesives
PP
m
Compact and sturdy construction
Good pressure resistance
Disposable design, easy change-out
Filters produced in a controlled environment
Manufactured according to ISO9001 certified
Quality Management System
F P φ50 Filter Unit
Small-volume venting
Vent device for sensor
Small or medium batch filtration
Outer DiameterΦ or PTFE
nlet utlet
Φ 0 or PES lon PP F PVDF E
13 mm stepped hose barb connection wit 10 uer slip
For more information on specification, please refer to cartridges
with the same membrane.
Please refer t rderin nformation.
≥ 1 . m 0.0 1 ft
i uid . a 3 ,3.0 ar 0℃ ℃
ir as .0 ba 3 ,℃ ℃. ar 0
PES lon PTFE PP F EPVDF
49 www.lauterfilter.com
m
【 】【 】
F P 0 P 0
【 】【 】【 】
T
【 】
Membrane【 【
iop
harm
ac
eutic
al
@
3000
2500
2000
1500
1000
500
0 100 200 300 400 500
. μ
3000
2500
2000
1500
1000
500
0 10 20 30 40 50
Diff
eren
tial P
ress
ure(
mba
r)
Diff
eren
tial P
ress
ure(
mba
r)
( / ) ( / )
. μ
. μ
P ES P T FE
69.8
~70.
2mm
Ø58.6
6:100
6:100
for PES/Nylon/MCE/PP/GF69
.8~7
0.2m
m
Ø64.4
6:100
6:100
for PTFE
【 】【 】
P
one
PPP
lass Fiber
0 on Sterile
0 S
S
on Sterileterile
terile
【 】
P PP
DPE
0100
0
0.1μm0. μm
0. μm100 1.0μm
S PESlon
T drophobic PTFE
V PVDFE
F lass FiberP PP
T drophobic PTFE fo ir
T drophilicPTFE fo i uid
. μ
www.anowfilter.com51
®Easiprep syringe filters are charaterised by various membranes,
diameters, pore sizes and connectors. These filters are disposable,
ideal for clarification, sterile filtration, venting and other demands
in laboratory applications.
®E as ipr ep φ5/ Syringe Filterφ1 /φ /φ /φ
Qu al i t y
Appl icat ion
Filters produced in a controlled environment
Manufactured according to ISO9001 certified
Quality Management System
Clarification and particle removal
Sterile filtration
Venting and gas filtration
Chromatography sample preparation
F eat u r es a n d B en ef i t s
Low hold-up volume and low extractables
Various inlet/outlet connectors available
Gamma irradiated or EO sterilized
Various membrane diameter available
Broad chemical compatibility
Available in non-sterile and sterile version
13 mm 0 mm m 33 mm
PP DPE S PP DPE PP DPE
1.3 cm 3.1 cm . m . m
1 .0m 3.0mm 3.0mm 3. mm .0mm .3mm 0.0mm 30.3mm
< 100 l μ < 1 0μl < 0μl < 3 0μl
131 ℃( . ℉)
utocla e at 1 3℃ at 1 bar fo 0 minutes( 3. ℉@1 . psi)
< 0. ml as determined b h est
. ar 3. ar . bar . ar
Femal ue oc
al uer Slip
Femal ue oc
al ue oc
Femal ue oc
al uer Slip
Female ue oc
ale ue oc
ale uer Slip
ale uer Slip
Female ue oc
ale uer Slip
Please contact us for more details.
m
PP
0.1 m
1 .0m . mm
< 1 l μ
.0 bar
Femal uer Slip
al uer Slip
51 www.lauterfilter.com
Biop
harm
ac
eutic
al
Or der in g I n f or m at ion
【 】【 】
022 P 08N
【 】【 】【 】
T
【 】 【 【 【 】【 】
P
None_
PPP
Glass FiberG
1HN 100 Non-Sterile
2HN50S
1HS
200 Non-Sterile50 Sterile, EO
100 Sterile, EO
【 】
P
H
PP
HDPE
010022
045
0.1μm0. μm
0. μm100 1.0μm
S PESlon
T drophobic PTFE
V drophobic PVDF
EF lass Fiber
P PP
T drophobic PTFE fo ir
T drophilic PTFE
S
【 】【 】
nlet emale luer loc
utlet ale luer unloc
nlet ale luer unloc
utlet ale luer unloc
nlet emale luer loc
utlet ale luer loc
300 3.0μm00 .0μm
【 】
S
【 】
13
mm
13mm
0 0mm
mm
33 33mm0S
1 S
0 Sterile amma
100 Sterile amma
www.anowfilter.com53
Appl icat ion
Nylon
� Good mechanical strength � Resistant to alkaline solutions and most
organic solvent
� Alkali
� Organic solvents
� Transfer membrane
� Broad chemical compatibility
� Low protein binding and low extractables
� Terminal filtration
� Environment analysis
� Low protein binding
� Very suitable for biologics filtration
� Clarification
� Biologics
� Microbiological analysis
� Liquids contain protein
� SDI membrane
� Broad chemical compatibility
� Naturally hydrophobic
� Good heat resistance
� Gases
� Organic solvents � Corrosive liquid
� Naturally hydrophobic
� Low protein binding
� Good heat and chemical
resistance
� Gases
� Biologics
� Corrosive liquid
� Transfer membrane
53 www.lauterfilter.com
【 】【 】
MP 045 293 25
【 】【 】【 】
NN
【 】
Membrane【 【
54
Biop
harm
ac
eutic
al
This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact
【 】 【 】
G
【 】
Water flow2 rate(ml/cm min
△p=0.1Mpa)20 10 16 4 35 15 30 6 7 3
Sterilization By autoclave at 123 (253.4 ) or EO℃ ℉)
Material
Pore size(μm) 0.45 0.22 0.45 0.22 0.45 0.22 0.45 0.22 0.45 0.22
Bubble point(mbar)
Water@23 (73.4 )℃ ℉ 60%IPA@23 (73.4 )℃ ℉
150 310 150 310 250 350 60 100 40 70
Thickness(μm) 85-110 90-140 110-140 150-250 90-100
pH 3.5-8.0 6-13 1-14 1-14 2-10
010
022
045
0.1μm
0 22. μm
0.45μm
065 0.65μm
080
120
0 8. μm
1.2μm
300 3.0μm
047
090
142
47mm90mm
142mm150 150mm200
250
200mm250mm
293 293mm300 300mm
WithGWithoutN
NN Nylon
T Hydrophobic PTFE
TLHydrophilic
PTFE
M MCE
S PES
V PVDF
25 2550 50
Lauter.
www.anowfilter.com55
HY series sanitary housings are developed specifically for liquid filtration in the pharmaceutical, food&beverage, microelectronic and chemicalindustry.� Corrosion resistance and durability with 316L/304 stainless steel wetted parts and mirror-polished inner and outer surface� Enhanced cleanability and microbiological safety due to crevice-free, polished and hygienic design� Multiple choices for connections� Single-round and multi-round filter housings are available with cartridges of 10/ 20/ 30/ 40 inch� Cost-effective without sacrificing quality and performance
F eat u r es a n d B en ef i t s S peci f icat ion
Max im u m O per at in g P r es s u r e
Series Stainless Steel Filter Housing for Sanitary Liquid FiltrationH Y
�
�
�
�
�
Operator-friendly and long service life
Low adsorption, easy clean-up and back
washing
No shedding and no leakage
Good heat and corrosion resistance
Suitable for CIP and SIP
-marked�
6bar(87psi)
Max im u m Oper at in g T em per at u r e
Car t r idge Capaci t y
1-round, 3-round, 5-round, 7-round, 9-round, 11-round...
Con n ect ion
Inlet/Outlet
Gauge Port
Cartridge 222/Fin, 226/Fin, DOE
Flange/ Tri-Clamp
Flange/ Tri-Clamp
Housing
Clamp
Seal Silicone/EPDM/Viton/TEV
316L/304 stainless steel
304 stainless steel
140�( 284�)
55 www.lauterfilter.com
Order in g In f or m at ion
【 】【 】
HY 001 10
【 】【 】 【 】
D
【 【
56
Biop
harm
ac
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This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact
Single-round standard housings
05
10
20
30
225(8.9)
350(13.8)
600(23.6)
850(33.5)
84(3.3)
84(3.3)
84(3.3)
84(3.3)
110(4.3)
110(4.3)
110(4.3)
110(4.3)
127(5)
254(10)
508(20)
762(30)
111.6(4.0)
111.6(4.0)
111.6(4.0)
111.6(4.0)
200(7.9)
200(7.9)
200(7.9)
200(7.9)
C SUS304
D SUS316L
001003
005
009
13
57
0119
007
11
10
2030
40
10inch
20inch30inch
40inch
【 】【 】
T
【 】【 】
C
A 222/Fin
E DOEC 226/Fin S
E EPDM
V Viton
T TEVSilicone
【 】 【 】
F
K Tri-Clamp
F Flange
【 】【 】
25
20 DN20
2538
DN25DN38
40 DN40
Lauter
Lauter.
F eat u r es a n d B en ef i t s S peci f icat ion
Car t r idge Capaci t y
Con n ect ion
Inlet/Outlet
Gauge Port
Cartridge 222/Fin, 226/Fin, DOE
Flange/ Tri-Clamp
Flange/ Tri-Clamp
Housing
Clamp
Seal Silicone/EPDM/Viton/TEV
316L/304 stainless steel
304 stainless steel
www.anowfilter.com57
Max im u m O per at in g P r es s u r e
6bar(87psi)
140℃(284℉)
Series Stainless Steel Filter Housing for Gas&Air Filtration
HK series sanitary housings are developed specifically for gas&air filtration in
� Corrosion resistance and durability with 316L/304 stainless steel wetted parts and mirror-polished inner and outer surface� Enhanced cleanability and microbiological safety due to crevice-free, polished and hygienic design� Multiple choices for connections� Single-round and multi-round filter housings are available with cartridges of 10/ 20/ 30/ 40 inch� Cost-effective without sacrificing quality and performance
pharmaceutical, food&beverage, microelectronic andchemical industry.
�
�
�
�
Operator-friendly and long service life
Low adsorption
Mirror-polished inner and outer surface
No shedding and no leakage
-marked�
1-round, 3-round, 5-round, ...
57 www.lauterfilter.com
【 】【 】
HK 001 10
【 】【 】 【 】
D
【 【
Biop
harm
ac
eutic
al
This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact
C SUS304
D SUS316L
001
003
005
009
1
3
57
0119
007
11
10
203040
10inch
20inch30inch40inch
【 】【 】
T
【 】 【 】
C
A 222/Fin
E DOE
C 226/Fin SE EPDM
V Viton
T TEV
Silicone
【 】【 】
F
K Tri-Clamp
F Flange
【 】【 】
25
20 DN20
25 DN25
05
10
20
30
40
185(7.3)
310(2.2)
560(22.0)
810(31.9)
1060(41.7)
75(3.0)
75(3.0)
75(3.0)
75(3.0)
75(3.0)
158(6.2)
158(6.2)
158(6.2)
158(6.2)
158(6.2)
127(5)
254(10)
508(20)
762(30)
1016(40)
101.6(4.0)
101.6(4.0)
101.6(4.0)
101.6(4.0)
101.6(4.0)
250(9.8)
250(9.8)
250(9.8)
250(9.8)
250(9.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
20(0.8)
5 5inch
Lauter
Lauter
Lauter.
F eat u r es a n d B en ef i t s S peci f icat ion
Con n ect ion
Inlet/Outlet Flange/ Tri-Clamp
www.anowfilter.com59
Max im u m O per at in g P r es s u r e
6bar(87psi)
140�( 284�)
Series Filter Sanitary Disc Holder
HM series sanitary housings are developed specifically for
liquid and gas filtration in the
Corrosion resistance and durability with 316L/304
stainless steel wetted parts and mirror-polished inner
and outer surface
PTFE lining is available to provide advanced protection
from corrosion
pharmaceutical, food&beverage,
microelectronic and chemical industry.
●
●
●
●
●
Long service life
Low adsorption
Easy installation, clean up, and adjustment
No shedding and no leakage
Good heat and corrosion resistance
-marked�
Housing
Membrane Diameter
Seal Silicone/EPDM/Viton/TEV
316L/304 stainless steel
47mm, 90mm, 100mm, 142mm, 150mm, 293mm
59 www.lauterfilter.com
HM 293
【 】【 】【 】
D
【 【
Biop
harm
ac
eutic
al
This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact
C SUS304
D SUS316L
【 】【 】
S
【 】【 】
A
SE EPDM
V VitonT TEV
Silicone
【 】【 】
K
K Tri-Clamp
F Flange
【 】【 】
25
A
B
1
2
293mm Disc Filter Holder
293 294(11.5) 15(0.6) 15(0.6) 150(5.9) 293(11.5) 360(14.2)
047
090100
150
47
90100
142
293150
142
293
15 DN15
20 DN20
25 DN25
Lauter
Lauter.
F eat u r es a n d B en ef i t s S peci f icat ion
Con n ect ion
www.anowfilter.com61
Max im u m O per at in g P r es s u r e
6bar(87psi)
140℃(284℉)
Series Titanium Filter Housing
HT series sanitary housings are developed for liquid filtration in the pharmaceutical, food and beverage, microelectronic industry, especially suitable for carbon removal, high temperature and corrosive liquid filtration in infusion and injection manufacturing.� Corrosion resistance and durability with 316L/304 stainless steel wetted parts and mirror-polished inner and outer surface� Use titanium powder sintered filter� Side-in and down-out structure, with multiple choices for inlet and outlet connections� Easy clean up and backwash� Single-round and multi-round filter housings are available with cartridges of 10/ 20/ 30/ 40 inch
�
�
�
�
�
Long service life
Low adsorption
No shedding and no leakage
Good corrosion and acid and alkali resistance
Titanium filter is reusable
-marked�
Housing
Clamp
1-round, 3-round, 5-round, 7-round, 9-round, 11-round
Inlet/Outlet
Cartridge
Seal Silicone/EPDM/Viton/TEV
316L/304 stainless steel
Flange/ Tri-Clamp
316L/304 stainless steel
Gauge Port Flange/ Tri-Clamp
M20/M30 Thread
61 www.lauterfilter.com
HT 011
【 】【 】【 】
D
【 【
Biop
harm
ac
eutic
al
This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact Lauter.
C SUS304
D SUS316L
【 】【 】
S
【 】【 】
M2
S
E EPDM
V Viton
T TEV
Silicone
【 】【 】
K
K Tri-Clamp
F Flange
【 】【 】
25
25 DN25
38 DN3840 DN40
M2
M3
M20
M30
10
20
30
40
10inch
20inch
30inch
40inch
5-Round standard housing of 20”
20 508(20) 440(17.3) 420(16.5) 200(7.9) 200(7.9) 290(11.4) 14(0.6) 14(0.6) 121(4.8)
001
003
005
009
1
3
5
7
0119
007
11013 13
【 】【 】
10
50 DN50
Lauter
F eat u r es a n d B en ef i t sS peci f icat ion
Con n ect ion
www.anowfilter.com63
Max im u m O per at in g P r es s u r e
6bar(87psi)
140℃(284℉)
●
●
●
Fast filtration, long service life
Mirror-polished inner and outer surface
Low adsorption, no shedding and no leakage
-marked�
Series Sanitary In-line Liquid and Gas Filter Housing
HG series sanitary housings are developed specifically for liquid filtration
in the
such as pure water, ultra pure water, drinking water, distilled water,
acid and alkali, and other chemicals.
Corrosion resistance and durability with 316L/304 stainless steel wetted
parts and mirror-polished inner and outer surface
Enhanced cleanability and microbiological safety due to
crevice-free, polished and hygienic design
Multiple choices for inlet and outlet connections
Single-round and multi-round filter housings are available
pharmaceutical, food&beverage, microelectronic and chemical
industry
Housing
Clamp
1-round, 3-round, 5-round
Inlet/Outlet
Cartridge
Seal Silicone/EPDM/Viton/TEV
316L/304 stainless steel
304 stainless steel
Flange/ Tri-Clamp
222/Fin, 226/Fin, DOE
63 www.lauterfilter.com
Biop
harm
ac
eutic
al
This information is a guide to the Part No. structure and possible options. For availability of specific options and housing details, please contact
Single-round standard housings
05102030
127(5)
254(10)
508(20)
762(30)
225(8.9)
350(13.8)
600(23.6)
850(33.5)
44(1.7)
44(1.7)
44(1.7)
44(1.7)
101.6(4.0)
101.6(4.0)
101.6(4.0)
101.6(4.0)
HG 001
【 】【 】 【 】
D
【 【
C SUS304
D SUS316L
【 】【 】
S
【 】 【 】
C
S
E EPDM
V VitonT TEV
Silicone
【 】 【 】
K
K Tri-Clamp
F Flange
【 】【 】
25
10
2030
10inch
20inch30inch
001003005
009
1357
011
9007
11
【 】【 】
10
A
C
222/Fin
226/Fin5 5inch DN15
20 DN
25
38
40
15
20
DN 25
DN 38
DN 40
Lauter.
Lauter.
Ch em ical Com pat ibi l i t y Gu ide
Classification Name Nylon PVDF PTFE PES PP MCE Silicone EPDM Viton TEV
Acids
Acetic Acid NR R R NR R LR LR R NR RHydrochloric Acid (conc.) NR R R R R NR NR NR NR RHydrochloric Acid (6N) NR R R R R NR NR NR R RNitric Acid (conc.) NR R R - R NR NR NR R RNitric Acid (6N) NR R R - R NR LR NR R RPhosphoric Acid (conc.) NR R R - R NR NR R R R
Sulfuric Acid (conc.) NR R R NR R NR NR NR R RHydrofluoric Acid (6N) NR R R - NR NR NR NR - R
Bases
Ammonium Hydroxide (1N) R LR R R R R R R R R Ammonium Hydroxide (3N) R NR R R R NR R LR LR R Potassium Hydroxide (3N) R LR R R R NR LR R R R Sodium Hydroxide (3N) R LR R R R NR R R R R Sodium Hydroxide (6N) R NR R R R NR R R R R
Alcohols
Amyl Alcohol R R R R R NR NR R R R Benzyl Alcohol (100%) R R R R R NR LR R R R Butanol R R R R R R R R LR R Isopropanol R R R R R - R R R R Methanol LR R R R R LR R R NR R
Ketones
Acetone R LR R NR R NR NR R NR R Cyclohexanone - LR R NR R NR NR NR NR R Methyl Ethyl Ketone LR LR R - R - NR R NR R Methyl Isobutyl Ketone LR LR R NR R - NR R NR R
Oils
Cottonseed R R R - R - R R R Lubricant R R R NR R - R R R R Peanut R R R - R - R R R R
Sesame R R R R R - R R R R
Aromatic
Hydrocarbons
Benzene LR LR R LR NR R NR NR R R Toluene NR LR R NR NR R NR NR R R
Xylene LR LR R NR NR R NR NR R R
Halogenated Hydrocarbons
Carbon Tetrachloride LR LR R LR LR NR NR NR R R Chloroform LR LR R NR LR NR NR NR R R
Ethylene Dichloride LR LR R NR LR R NR NR LR R Freon TF R R R R LR R NR NR R R
Freon TMC LR LR R NR LR R NR NR LR R Methylene Dichloride NR LR R NR LR NR NR NR LR R Perchloroethylene - LR R LR LR R NR NR R R
Trichloroethylene LR NR R LR LR R NR NR R R
65 www.lauterfilter.com
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66
Glycols Ethylene Glycol R R R LR R - R R R R
Glycerol R R R LR R R R R R R Propylene Glycol R R R LR R R R R
Ethers
Ethyl Ether NR R R R LR NR LR NR NR R Isopropyl Ether - R R - R NR NR NR NR R
Dioxane R R R - R NR NR NR NR R Tetrahydrofuran NR LR R NR LR NR NR NR NR R
Esters
Amyl Acetate LR R R - R NR NR R NR R Butyl Acetate LR R R - LR NR NR R R R
Cellosolve Acetate - R R R R NR NR R NR R Ethyl Acetate LR R R LR LR NR R R R R Methyl Acetate LR R R NR R NR - R R R
Isopropyl Acetate - R R R R NR LR R NR R
Classification Name Nylon PVDF PTFE PES PP MCE Silicone EPDM Viton TEV
Connections
Aniline LR R R NR LR - NR R R R Dimethyl Formamide R NR R NR R - R R NR R
Formaldehyde (37%) R R R R R - R R NR R Gasoline LR LR LR R LR R NR R R R Hexane (dry) - LR LR LR LR R NR NR R R
Kerosene - R R R R - NR NR R R Phenol R R R NR R R NR NR R R
Pyridine LR R R NR LR NR NR R NR R Turpentine - R R R LR - NR NR R R
Water R R R R R R LR R R R Acetonitrile LR R R R LR NR - R NR R Nickel Sulfate Solution R R R - R - R R - R
Notes: This table is intended to serve as a guide only. Accuracy cannot be guaranteed. Users are responsible
for verifying chemical compatibility under their own conditions of use. Chemical compatibility is affected by
many variables including temperature, pressure, concentration, and chemical purity.
R: Resistance;
LR: Limited resistance;
NR: No resistance;
“-”: No data available.
R
Miscellaneous
222/Fin 222/Flat 226/Fin 226/Flat DOE
Lauter Filter a brand manufactured by:Hangzhou Anow Mincrofiltration Co., Lta.
Website: www.lauterfilter.comE-mail: sales@lauterfilter.com
www.lauterfilter.com
Office: Room 901-903, Central Building, No. 271, HushuS outhRoad, Hangzhou, ChinaPlant: Qingming Bridge,X in deng industrial Zone, Fuyang, Hangzhou,China
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