Basic catalytic principles

• Covalent catalysis: The active site contains a reactive group (nucleophile) that becomes covalently modified

• General acid-base catalysis: a molecule other than water plays proton donor or acceptor

• Metal ion catalysis: Electrophilic catalyst or water activator

• Catalysis by aproximation

Serine is part of a Asp-His-Ser catalytic triad

Serine- acid-donate proton to the Histidine to form the nucleophic O-. His- base. Em hieu nhu vay dung chua anh?

Anh giai thich dum em phan nay voi, trogn sach noi la: dua tren Base-acid catalyse, va covalent catalysis. Ko biet co che nao di voi hinh nao. Co phai phan ung 3, 4, 5,6 la pu dua tren covalent catalysis? Cach nao de biet dc vay?em ko hieu phan nay.