Applied Bioinformatics & Chemoinformatics: Techniques, Tools and Opportunities.

FATOKI, Toluwase H.Department of Biochemistry,

Federal University of Technology, Akure, Nigeria. +2347032219821

hezekiahfatoki@gmail.com www.linkedin.com/in/hezekiahfatoki

www.fheztbioinformatics.wordpress.com

“None of us is as smart as all of us” – Ken Blanchard.“If you want to go fast, go alone. If you want to go far, go together.” – African Proverb.

OUTLINES• Introduction to Genetic Engineering• Sequencing: The Next Generation• Introduction to Bioinformatics• Overview of Bioinformatics in Africa• Essential Bioinformatics• Introduction to Database and Tools• Introduction to Chemoinformatics/Pharmacoinformatics• Applications of Bioinformatics• Application in Biotechnology Industries• Application in Biomedical and Biopharmaceuticals Industries• Current Trends and Opportunities• Questions and Answers

Introduction to Genetic Engineering

• The Central Dogma

• Concept Maps of Genetic Engineering

Sequencing: The Next GenerationA Life Decoded is the story of this singular milestone in our history, told by the man who through a combination of vision, tenacity, ingenuity, and insight challenged conventional wisdom and refuted his critics to reveal the human genetic code.

Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Introduction to Bioinformatics

Overview of Bioinformatics in Africa

Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Medha Bhagwat, PhD. NIH Library Bioinformatics Support Program

Essential Bioinformatics• Section I: Introduction And Biological Databases• Section II: Sequence Alignment• Section III: Gene And Promoter Prediction• Section IV: Molecular Phylogenetics• Section V: Structural Bioinformatics• Section VI: Genomics and Proteomics

Arthur M. Lesk,(2002). Introduction to Bioinformatics, Oxford University Press, New York

Introduction to Databases and Toolshttp://www.cbs.dtu.dk/biotools/http://molbiol-tools.ca/molecular_biology_freeware.htmhttp://www.hpc.cam.ac.uk/compbio/softwarehttp://bioinformaticssoftwareandtools.co.in/bio_tools.phphttp://www.bioafrica.net/software.php

• NCBI: The National Center for Biotechnology Information (USA): http://ncbi.nlm.nih.gov

• EBI:The European Bioinformatics Institute: www.ebi.ac.uk

• SIB:The Swiss Institute of BioinformaticsExpasy (Expert Protein analysis system): www.expasy.org

• Canadian Bioinformatics Resource http://cbr-rbc.nrc-cnrc.gc.ca/

Chemoinformatics/Pharmacoinformatics

Darren Green, (2016). Computational Drug discovery.

The computational methods for in silico drug discovery have been

broadly categories into two fields bioinformatics and chemoinformatics.

In case of bioinformatics, major emphasis is on identification and

validation of drug targets, mainly based on functional/structural annotation

of genomes.

In case of cheminformatics or pharmacoinformatics, major emphasis is

on designing of drug molecules or ligands and their interaction with drug

targets.

Frank K. Brown (1998) defined Chemoinformatics as the mixing of

information resources to transform data into information, and information

into knowledge, for the intended purpose of making better decisions faster

in the arena of drug lead identification and optimization.https

://fheztbioinformatics.wordpress.com/2017/02/04/bioinformatics-chemoinformatics-and-drug-discovery/

APPLICATIONS OF BIOINFORMATICS

Application in Biotechnology Industries

Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Application in Biomedical and Biopharmaceuticals Industries

Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.

Jurgen Drews (2000). Drug Discovery: A Historical Perspective, Science/Drug Discovery, vol.287, 1960-1964.

Current Trends and Opportunities

Jobs, PhDs and Networkshttp://blog.biogem.org/2013/03/bioinformatics-carrer-opportunities.htmlhttp://www.sib.swiss/about-us/careershttp://www.nature.com/naturejobs/science/jobs?q=bioinformaticshttp://www.bioinformatics.org/jobs/http://www.linkedin.com/topic/bioinformatics http://www.linkedin.com/topic/computational-biology Online Courseshttps://www.futurelearn.com https://www.coursera.org

Thanks for

listening