Post on 14-Jul-2015
Malabsorption of iron, folate, calcium and fat soluble vitamins results in iron deficiency, folate deficiency and reduced bone density
Infants and young children present with diarrhoea, abdominal distension and FAILURE TO THRIVE
Calcium malabsorption Vitamin D malabsorption Secondary hyperparathyroidism Failure of peak bone density as child Reduced gonadal function in men Autoimmunity
Delayed menarche Premature menopause Amenorrhoea recurrent miscarriages Infertility & low birthweight babies Increased perinatal mortality
Coeliac Disease Diabetes Mellitus Autoimmune Thyroid Disease / MS Rheumatoid Arthritis / Psoriasis Glomerulonephritis
Antibodies disappear on a gluten free diet
Anaemia Allergies Thyroid Disease Lactose Intolerance IBS, CFS
IDDM Thyroid disease Sjogrens
D�isease Renal Disease
Addisons Disease
Cardiomyopathy Neurological
disorders Autoimmune
liver disease
Antibodies against gliadin (IgA-AGA, IgG-AGA) Endomysial antibody (IgA-EMA) Tissue transglutaminase antibody (IgA-tTG) Total IgA
Malignant diseases are more frequent in coeliacs
Small bowel CA Oesophageal & oropharangeal CA Non-Hogkins lymphoma
Autistic children respond to gluten-free,casein-free diet
Improved speech, social behaviour, sleeping habits
Food peptides affect ADHD
Depression & morphine-like exorphins
Oats are not toxic to patients with Coeliac Disease or Dermatitis Herpetiformis
Genetic link (HLA-DQ2 and HLA-DQ8) in patients with coeliac disease
Alpha-gliadin has immunoreactve peptides
Hyphal wall protein (HWP 1) in C. albicans. Similar epitopes in gliadin
Yeasts adhere to gut via transglutaminases
Gliadin deamidated via transglutaminases
Yeast & gluten provide T-cell epitopes (reactive peptides which trigger antibodies) Autoreactive antibodies form against tissue
transglutaminases and endomysium peptides
Increased candida overgrowth Damage to gut Increased exposure of transglutaminases Increased binding of candida HWP 1 Tissue transaminases (autoantigen)
recognised by autoreactive antibodies
Introduce gluten while breast feeding Small quantities of gluten only Keep breast feeding after gluten exposure Breast feeding at exposure increases oral
tolerance Breast feeding protects against Diabetes
type 1, IBS and Leukaemia
Milk Allergy
Milk Intolerance
Uncommon, Small amounts trigger IgE mediated Reactions sudden
Common Normal amounts trigger Not IgE mediated Skin tests Negative Reactions delayed (4-26 days)
Masking- Remove dust, mould, dogs etc
Glue ear- Are parents atopic?
IBS- Milk & wheat increase rectal PGʼs
Asthma- Look for milk addiction
Eczema- >2 allergens (related to asthma)
Total Fat (% total energy) No IHD IHD Framington 38.8 40.0 Puerto Rico (urban) 36.6 37.7 Puerto Rico (rural) 32.2 32.0 Honolulu 33.3 35.2 London 40.5 40.0 Zutphen 41.7 41.8 Ireland/Boston 38.5 39.4 Caerphilly 40.1 40.9
Glucose-Galactose (disaccharide) 12g per 250ml milk Reduced in yogurt/fermented milk Absent in hard cheese Intolerance when lactase deficient
Examination of 23,207 sets of coronary arteries and aortas revealed severity of atherosclerosis was related to:
Highest daily milk consumption Those with highest lactase activity
Men 55-64 yrs had the same cholesterol and sat. fat intake (1950-1980) but IHD mortality was highest in Finland. Why?
(Wine and ethanol intake was the same)
The Finns drank 3.4 times more milk
During 1972-92 there was a dramatic decline in IHD in Finland as milk consumption declined .
Cheese intake increased 3 times during this period
Japan,China, Greenland Eskimos (heavy smokers, low wine intake)
Masai of East Africa (drink fermented milk low in lactose)
South African Blacks, Afro-Carribeans, Prima Indians, Shri Lankans (low milk,low lactose)
North Indians, Pakistanis and British have elevated IHD, high milk intake and high lactase levels
Milk intake - 66% less than UK Fat intake - 33% more than UK Cheese intake 300% more than fresh milk
Lactase activity: Northern France - 50% less than Europe Southern France - 25% less than Europe
Galactose (and Fructose) preferentially glycate proteins especially LDL.
This makes LDL more susceptible to oxidation and thus atherosclerosis
Is high lactose consumption merely
a marker for β-casein intake?
“The rate of β-Casein A1 consumption (excluding cheese) is a more accurate predictor of heart disease…. Than that reported for traditional risk factors”
CHOLESTEROL BLOOD PRESSURE SATURATED FATS OBESITY Varied in relative contribution to illness
A survey of 39 centres in 26 countries
0100200300400500600
Relative Indidence of
Diabetes
Low MilkDiet
High MilkDiet
Ulcer withSippy
Ulcer with no Sippy
No Ulcer
05
10152025303540
% Relative
Incidence of Myocardial
Infarct
USA Britain
A1 CHD
A1
00.5
11.5
22.5
33.5
Relative Incidence of
Heart Disease
Toulouse Belfast
CHD
Rennet and subsequent enzymatic action as cheese ages causes alterations to
the cheese protein structure causing cross-linking of casein molecules.
Casomorphin-7 is absent in most cheeses
Casein causes heart disease in animals Casein accelerates hypercholesterolaemia and atherosclerosis in animals Apo E deficient atherosclerosis prone mice
get more lesions Longevity in animals decreased by casein (compared with soy and whey) Pigs fed casein have elevated homocysteine