Post on 30-Dec-2015
ACRIN Fall Meeting 2008
Mitchell Schnall MD, PhDProfessor of RadiologyUniversity of PennsylvaniaACRIN Network Chair
State of ACRIN : 10 years of investment
ACRIN Fall Meeting 2008
1. Strategies for Imaging Surveillance of Populations at High Risk for Cancer
2. Imaging Approaches to the Characterization of Disease in Order to Guide Targeted Therapy
3. Biomarkers of Therapeutic Response for Implementation in Clinical Trials and Clinical Care
Primary Scientific Objectives
ACRIN Fall Meeting 2008
ACRIN ORGANIZATION: 1999
Data and Safety Monitoring Committee
Network ChairNetwork Deputy Chair
Advisory Panel
Vice ChairModalities
Vice ChairBasic Sciences
Vice Chair for Institutional
Participants
Vice ChairIndustry/Insurers
Vice ChairPublications
Urinary
GYN
Breast
Head & Neck
CNS
Musculoskeletal
Lung
Pediatrics
Heart & Vasculature
Receptor Delivery Sys
Nuc MedPET/Spect
Ultrasound
Conventional/CT
Psychophysics
MRI/MRS
GI
Design & Analysis
NetworkAdministration
Biostatistical & DataManagement Center
Vice ChairDisease Sites
Functional/Meta-bolic Imaging
InterventionalMin Invasive
Image & InfoTech
Outcomes andQuality of Life
Economics and Cost Impact
Oncologic Pathology
Quality Contol
Medical Specialties
Advisory Comm.
SpecialPopulations
Physics &Engineering
InstitutionalParticipants
Vice ChairMethods
Scientific Committees
ACRIN Fall Meeting 2008
ACRIN Organizational Chart
Institutional Participants CommitteeVice Chair
Chris Comstock, MDUCSD
Institutional Participants CommitteeVice Chair
Chris Comstock, MDUCSD
Media / Publications and
DisseminationCommitteeVice Chair
Laurie Fajardo, MDUniversity of Iowa
Media / Publications and
DisseminationCommitteeVice Chair
Laurie Fajardo, MDUniversity of Iowa
Special PopulationsElizabeth Patterson, MD
Special PopulationsElizabeth Patterson, MD
Research AssociatesWendy Smith, RT
Rhode Island Hospital
Research AssociatesWendy Smith, RT
Rhode Island Hospital
Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania
Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania
Patient AdvocacyBarbara LeStage, MHP
Patient AdvocacyBarbara LeStage, MHP
Outcomes & Economics Core
LaboratoryWilliam Black, MD
Dartmouth Medical School
Outcomes & Economics Core
LaboratoryWilliam Black, MD
Dartmouth Medical School
Advisory PanelHal Kundel, MD
University of Pennsylvania
Advisory PanelHal Kundel, MD
University of PennsylvaniaLeadership Council
Mitchell Schnall, MD, PhDUniversity of Pennsylvania
Leadership CouncilMitchell Schnall, MD, PhD
University of Pennsylvania
Biostatistical & Data Management Center
Brown UniversityChair
Constantine Gatsonis, PhD
Deputy Chair Jeffrey Blume, PhD.
Biostatistical & Data Management Center
Brown UniversityChair
Constantine Gatsonis, PhD
Deputy Chair Jeffrey Blume, PhD.
Steering Committee
Network ChairMitchell Schnall, MD,
PhDUniversity of Pennsylvania
Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD
UCLA
Molecular ImagingBarry Siegel, MD
Washington University
Steering Committee
Network ChairMitchell Schnall, MD,
PhDUniversity of Pennsylvania
Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD
UCLA
Molecular ImagingBarry Siegel, MD
Washington University
AbdominalFergus Coakley, MDUniv Calif San Francisco
AbdominalFergus Coakley, MDUniv Calif San Francisco
Head/Neck/CNSGreg Sorensen, MD
Massachusetts General Hosp
Head/Neck/CNSGreg Sorensen, MD
Massachusetts General Hosp
BreastEtta Pisano, MD
University North Carolina
BreastEtta Pisano, MD
University North Carolina
ThoracicCaroline Chiles, MDWake Forest University
ThoracicCaroline Chiles, MDWake Forest University
Gynecological Gynecological
Disease SiteCommittees
Scientific SupportCommittees
Experimental ImagingDavid Mankoff, MD
University of Washington
Experimental ImagingDavid Mankoff, MD
University of Washington
InformaticsDaniel Rubin
Stanford University
InformaticsDaniel Rubin
Stanford University
Core Laboratory
PET/Nuc MedicineBarry Siegel, MD
Washington University
MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania
Core Laboratory
PET/Nuc MedicineBarry Siegel, MD
Washington University
MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania
Ultrasound Working Group
Barry Goldberg, MDThomas Jefferson University
Ultrasound Working Group
Barry Goldberg, MDThomas Jefferson University
NCIJim Tatum, MD
Cancer Imaging Program
NCIJim Tatum, MD
Cancer Imaging Program
Network AdministrationCharles Apgar
ACR Philadelphia
Network AdministrationCharles Apgar
ACR Philadelphia
Data & Safety Monitoring Committee
Daniel Sargent, PhDMayo Clinic
Data & Safety Monitoring Committee
Daniel Sargent, PhDMayo Clinic
SupportCommittees
ACRIN Fall Meeting 2008
Scientific ProgressACRIN Trial Status by Disease Site
Disease Site OpenedCompleted
AccrualIn
DevelopmentClosed
Unsuccessfully
Breast 1 4 1 0
Abdominal 2 4 1 2
GYN 1 1 1 0
CNS/Head and Neck
1 2 2 0
Thoracic 2 1 1 1
EISC 0 0 2 0
ACRIN Fall Meeting 2008
ACRIN Success
117 sites have participated ACRIN trials Over 76,500patients have been accrued to
ACRIN trials Over 20 million images have been collected
into the ACRIN database Over 70 abstract presented
10 ACRIN research presentation scheduled at RSNA 2008 Over 50 Scientific publications
3 NEJM/1JAMA
ACRIN Fall Meeting 2008
Extending ACRIN’s Impact
Awarded RO1 for establishing VIEW Imaging core lab services to the cooperative groups Partner with QARC and CALGB
Established ACRIN PA Supported by PA tobacco fund Cartilage Assessment Radial DCE MRI Amyloid imaging Coronary CTA
*Developed the ACRIN Cardiovascular Committee ACRIN “projects”
*initiative supported by the ACRIN Fund for Imaging Innovation
ACRIN Fall Meeting 2008
Challenges
Strong scientific pipeline Balance in the research portfolio Focus on imaging science Engagement of clinical community
Maintaining accrual Build publication record
ACRIN Fall Meeting 2008
Cost per case has been increasing
Assuming 6 committees:
73 cases/committee/year
ACRIN Fall Meeting 2008
Primary Scientific Objectives
Presentation to Steering Committee Written Concept Trial PI / Committee Chair Present
ACRIN SCIENTIFIC COMMITTEESReview Idea Impact Feasibility Strategy
Develop Concept Assemble Experts Symposium at Fall Meeting Define Imaging Approach Identify Collaborators
ACRIN STEERING COMMITTEEReview with Respect to: Scientific Impact Generalizability of Technology Feasibility Cost
IndividualInvestigators
Committee Members
CooperativeGroups
Trial Ideas
OutcomeEconomics
Biostatistics
Steering Committee Response Approve for Development and CTEP Concept Submission Disapprove Request Revision
PatientAdvocacy
SpecialPopulations
INPUT from ACRIN Resources
ImagingCore Lab