A Little Lite Goes A Long Way®

The Litebook Company Ltd.

www.litebook.com

Presented by:

Larry Pederson, Founder

September 2007

The Light You Need … Every Day®www.litebook.com

The Litebook® Elite™

A New Generation of

Light Therapy™

We live in a light-deprived world...

…And we are paying for it with our health.

Why we are ‘light deprived’ Work indoors

Play indoors

Travel indoors

Many now believe that sunlight = bad

ozone layer depletion = > UV radiation

> risk of skin cancer

Avg. exposure 57 mins/day in sunny San Diego! (Dr. Kripke, UCSD 2004)

Are your customers ‘light deprived’…?Are they:

Office worker

Stay-at-home mom

Elderly

Teen

Shift-worker

Business traveler

Anyone…??

You…??

What is S.A.D.? DSM-IV Definition:

Major depression indications, plus:

Relationship between onset of major depressive episodes and particular time of year.

Full remissions also occur at characteristic time of year.

Seasonal depressive episodes substantially outnumber non-seasonal episodes, for > 2 years.

What is ‘Winter Blues’? Sub-syndromal Seasonal Affective Disorder

Similar but milder indications

Not ‘clinically depressed’ -- do not typically require Rx

Often mis-diagnosed or non-diagnosed

Seasonal component as with SAD

SAD Facts: Incidence in Canada:

2-5% (est.)

‘Winter Blues’ - additional 25% (NMHA’02)

Increases with latitude

Gender: 75% Female vs. 25% Male

Age: Typical onset is early 20’s - mid-40’s

SAD Symptoms (Seasonally): Depressed mood most of the day, nearly every day.

Marked diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day.

Decreased energy

Decreased self-esteem

Increased appetite and/or weight

Carbohydrate craving

Hypersomnia

Difficulty concentrating

Irritability

Social withdrawal

Decreased libido

Treatment Options for SAD:

Medications:

SSRI’s (Prozac, Zoloft, etc.)

Wellbutrin XL – newly approved by FDA

Light therapy:

Daily early morning scheduled exposure to bright artificial light

Response rate: range 60% - 90%; avg. 65%

Combined light & medication

Light Therapy for SAD: Long considered ‘alternative therapy’

Now becoming preferred treatment option with psychiatrists, GPs and psychologists

Patient-driven -- many w/ SAD don’t view themselves as having psychiatric illness = do not want to take Rx meds

Some patients do well on Rx; some don’t

Many do better on light therapy than on Rx

FDA review: data on light therapy for SAD is “overwhelming and irrefutable”

Other Indications for Light Therapy: Shift-work

Jet lag

Sleep Disorders –

Delayed Phase Sleep Disorder (DPSD)

Advanced Phase Sleep Disorder (APSD)

Fatigue Management (CFS, MS, Chemo pts.)

Performance enhancement – athletes, execs

‘Baby Blues’ & Post-partum depression

Contraindications for Light Therapy:

No evidence of danger using 10K light boxes – or The Litebook (in market since 2001; 46 countries)

Older patients w/ history of eye problems (cataracts, macular degeneration, diabetes w/ retinopathy) should have eye exam or consult eye doc before using

Corrective laser eye surgery in past 30 days

Currently taking any Rx w/ photosensitivity profile -- UV triggers reaction (Litebook Elite emits NO UV).

Bi-polar on antidepressants could become manic, trigger hypomania = use under careful medical supervision

Recommend consult with MD or ophthalmologist prior to using light therapy

Why does Light Therapy Work?

No definitive answer yet

Bright light does impact melatonin and serotonin levels

Melatonin produced in response to ‘low light’ or ‘no light’

Critical discovery (1979): bright light suppresses melatonin

Critical discovery (2001): blue wavelength light most effective for melatonin suppression

How Light Therapy Works

Mechanism:

Bright light strikes retinal non-visual photoreceptor (melanopsin)

optic nerve

Suprachiasmatic nucleus (SCN)

pineal gland

melatonin suppression

phase shift

Melatonin Suppression Curve

Primary = 464nm (blue) Secondary = 550nm (green)

Litebook’s white LEDs = Efficiency2

Sunlight & The Litebook®

Traditional Light therapy

Litebook ‘Knock-offs’

The Litebook® Elite™

What Makes The Litebook® Elite™ Unique:

Our Advantages: Clinically proven for SAD Patented LED technology Completely portable

Rechargeable lithium-Ion battery (2 hrs fully charged)

Timer: 15-30-45-60 mins.Compact: 12.5cm x 12.5cm x 2.5cm Lightweight – 327gLow power – 2.4 WattsLow heat UV-free, long-lasting white LEDsCustom Fresnel lens/diffusion system EU Medical Device Certified - CE0086 ISO 9001 & ISO 13485 certified

Litebook Leads in Research: SAD: Pub. Aug 07 – BioMed Central online journal

Canada: UBC; McGill; Royal Ottawa Hospital USA: Yale University Europe: U of Groningen, The Netherlands

Litebook + Exercise = Body Fat Reduction:

Pub. July07 – Journal of Obesity Vol. 15, No. 7

Toronto Western Hospital

Shift-work: Canada: McGill & Montreal Police (COMPLETED)

UK: U of Surrey - North Sea drilling platform (COMPLETED)

Teens with ADHD: U of Maryland – Baltimore, MD (ONGOING)

Anxiety Disorder: U of South Carolina – Columbia, SC (ONGOING)

Fatigue Mgmt in Chemo Patients: UC San Diego (ONGOING)

Litebook’s Scientific Advisory Board: Dr. Raymond Lam M.D.

Director, Mood Disorders Clinic, University of British Columbia

Dr. Dan Oren M.D.

Associate Clinical Professor of Psychiatry, Yale University

Dr. Siegfried Kasper M.D.

Professor & Chair, Dept. of Gen. Psychiatry, U of Vienna

Dr. Oscar Cuzzani M.D.

Ophthalmologist; Retinal Surgeon, Researcher (Light Toxicity)

Dr. James Maas Ph.D.

Professor & Past Chair, Dept. of Psychology, Cornell U.

(cont’d)

Litebook’s Scientific Advisory Board:

Dr. Carlan Silha Ph.D.

Systems & Engineering Mgmt; Lt. Col USAF (Ret.); Retired Boeing

Mr. Cal Koskowich P.Eng.

National Research Council of Canada

Mr. Larry Crabb

Col. RCAF (Ret.); ISO Compliance & Business Development Consultant

Litebook Usage:

The Litebook® Elite™ Packaging

- Strong shelf appeal - Every unit has ‘demo’ feature- Bilingual packaging – Canada/EU

Litebook Summary:

A new generation of light therapy

Patented white LEDs = safe, long life, low power

Blue wavelength peak = shorter treatment time

Feature-rich, user-friendly product design

Clinically proven

World-class Scientific Advisory Board

Industry leading 60-day money-back guarantee

Low return rate: < 0.5%

2-year warranty

A Little Lite Goes A Long Way®

The Litebook Company Ltd.

www.litebook.com

Presented by:

Larry Pederson, Founder

September 2007

The Light You Need … Every Day®www.litebook.com