4th International Workshop on Clinical Tolerance

4th INTERNATIONAL WORKSHOP ON CLINICAL

TOLERANCE September 5 – 6, 2019

University Club, Ballroom B 123 University Place

Pittsburgh, PA

4th International Workshop on Clinical Tolerance September 5 – 6, 2019 Pittsburgh, PA – USA

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TABLE OF CONTENTS 1

Welcome 2

International & Local Organizing Committee 3

Program Thursday, September 5th 4

Friday, September 6th 8

Speakers 11

Map 13

Notes 14

Reimbursement Information 18

W-8 Form 19

W-9 Form 20

Conference Organizer

Kristie Bowman University of Pittsburgh BowmanKL2@upmc.edu Cell: (412) 915 - 2432

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On behalf of Dr. Angus Thomson, Dr. Fadi Lakkis and the International Advisory Committee, we would like to welcome you to the 4th International Workshop on Clinical Tolerance.

We would like to thank our generous sponsors in helping support this workshop:

Previous Workshops:

2017: Stanford, California

2015: Chicago, Illinois

2014: Boston, Massachusetts

Welcome to Pittsburgh, Pennsylvania!

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International Organizing Committee

Fadi Issa University of Oxford fadi.issa@nds.ox.ac.uk

Tatsuo Kawai Massachusetts General Hospital Tkawai@mgh.harvard.edu

Joe Leventhal Northwestern University jleventh@nm.org

Samuel Strober Stanford University sstrober@stanford.edu

Megan Sykes Columbia University ms3976@cumc.columbia.edu

Larry Turka Harvard University lturka@partners.org

Kathryn Wood University of Oxford Kathryn.wood@nds.ox.ac.uk

Local Organizing Committee

Angus Thomson University of Pittsburgh thomsonaw@upmc.edu

Fadi Lakkis University of Pittsburgh lakkisf@upmc.edu

Abhi Humar University of Pittsburgh humara2@upm.edu

Warren Shlomchik University of Pittsburgh warrens@pitt.edu

Paul Szabolcs University of Pittsburgh szabolcsp@upmc.edu

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THURSDAY, SEPTEMBER 5, 2019 Ballroom B, 2nd floor

7:00 am – 8:00 am: REGISTRATION & BREAKFAST

8:00 am – 8:15 am: WELCOME AND INTRODUCTION – Angus Thomson (Co-Chair, Local Committee)

8:15 am – 9:55 am: TOLERANCE/IMMUNOSUPPRESSION WITHDRAWAL TRIALS: KIDNEY

MODERATORS: Christian Larsen Sam Strober

8:15 – 8:35: Sam Strober – Update on Stanford Chimerism Trials 8:35 – 8:40: QUESTION/ANSWER SESSION

8:40 – 9:00: Dixon Kaufman – Update on HLA-matched Chimerism Trial 9:00 – 9:05: QUESTION/ANSWER SESSION 9:05 – 9:25: Joe Leventhal – Update on Northwestern Chimerism Trial 9:25 – 9:30: QUESTION/ANSWER SESSION 9:30 – 9:50: Tatsuo Kawai – Update on the MGH Chimerism Protocol 9:50 – 10:00: Kyowon Lee – Update on the SMC Tolerance Induction Trial 10:00 – 10:05: QUESTION/ANSWER SESSION

10:05 – 10:15 am: COFFEE BREAK

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10:15 am – 12:55 pm: TOLERANCE/IMMUNOSUPPRESSION WITHDRAWAL TRIALS: LIVER

MODERATORS: Stuart J. Knechtle Joe Leventhal

10:15 – 10:35: Abhi Humar – Pitt LDLT DCreg Trial 10:35 – 10:40: QUESTION/ANSWER SESSION

10:40 – 11:00: Sandy Feng – UCSF Liver Immunosuppression Withdrawal 11:00 – 11:05: QUESTION/ANSWER SESSION

11:05 – 11:25: Josh Levitsky – ITN Liver Immunosuppression Withdrawal Update 11:25 – 11:30: QUESTION/ANSWER SESSION

11:30 – 11:40 am: BREAK

11:40 am – 12:00 pm: Alberto Sanchez-Fueyo – London Delayed Withdrawal Studies 12:00 – 12:05: QUESTION/ANSWER SESSION

12:05 – 12:25: Satoru Todo / Ryoichi Gotou – Anti-donor Treg Therapy – An Update 12:25 – 12:30: QUESTION/ANSWER SESSION

12:30 – 12:50: Ling Lu – Nanjing Trial 12:50 – 12:55: QUESTION/ANSWER SESSION

1:00 – 1:50 pm: LUNCH

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1:55 – 2:20 pm: TOLERANCE/IMMUNOSUPPRESSION WITHDRAWAL TRIALS: LUNG

INTRODUCTION: Fadi Lakkis

1:55 – 2:15: Paul Szabolcs – Pitt Combined HSCT + LUNG Transplantation 2:15 – 2:20: QUESTION/ANSWER SESSION

2:20 pm – 3:40 pm: NIH UPDATES

MODERATOR: Joren Madsen

2:20 – 2:35: Nancy Bridges – NIAID Clinical Trials in Organ Transplantation Update 2:35 – 2:40: QUESTION/ANSWER SESSION

2:40 – 2:55: Lis Welniak – NHLBI Clinical Trials in HSCT Update 2:55 -3:00: QUESTION/ANSWER SESSION

3:00 – 3:15: Sindhu Chandran – ITN Update 3:15 – 3:20: QUESTION/ANSWER SESSION

3:20 – 3:35: Joren Madsen – NHP Transplantation Tolerance Cooperative Study Group (NHPCSG) Update

3:35 – 3:40: QUESTION/ANSWER SESSION

3:40 pm – 3:55 pm: COFFEE BREAK

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3:55 pm – 5:15 pm: CELL THERAPY AND IMMUNOSUPPRESSION MINIMIZATION

MODERATOR: Qizhi Tang

3:55 – 4:15: Ed Geissler –ONE Study Clinical Results 4:15 – 4:20: QUESTION/ANSWER SESSION 4:20 – 4:40: Fadi Issa – Oxford/London ONE & TWO Study Updates 4:40 – 4:45: QUESTION/ANSWER SESSION

4:45 – 5:15: Sindhu Chandran/Joe Leventhal – U.S. Treg Trials Update 5:15 – 5:20: QUESTION/ANSWER SESSION

5:30 – 6:30 pm Cocktails on the Rooftop Terrace

6:30 pm Dinner Ballroom A, 1st Floor

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FRIDAY, SEPTEMBER 6, 2019 Ballroom B, 2nd floor

7:45 am – 8:30 am: BREAKFAST

8:30 – 9:20 am: MAKING CLINICAL HSCT SAFER

MODERATOR: Ephraim Fuchs

8:30 – 8:50: Warren Shlomchik – Memory T Cell Trial (Pitt & Hutch) 8:50 – 8:55: QUESTION/ANSWER SESSION

8:55 – 9:15: Sam Strober – Memory T Cell Trial (Stanford) 9:15 – 9:20: QUESTION/ANSWER SESSION

9:20 – 9:40: Everett Meyer - CAR-Treg Development 9:40 – 9:45: QUESTION/ANSWER SESSION

9:45 am – 10:00 am: COFFEE BREAK

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10:00 – 11:40 am: MECHANISTIC STUDIES & IMMUNE MONITORING

MODERATOR: Tatsuo Kawai

10:00 – 10:20: Angus Thomson – DCreg Mechanisms of Action and Monitoring 10:20 – 10:25: QUESTION/ANSWER SESSION

10:25 – 10:45: Megan Sykes – Tolerance Biomarkers 10:45 – 10:50: QUESTION/ANSWER SESSION

10:50 – 11:10: Birgit Sawitzki – ONE Study Mechanistic Insights 11:10 – 11:15: QUESTION/ANSWER SESSION

11:15 – 11:35: Valeria Mas – Intragraft Molecular Pathways Associated with Tolerance Induction 11:35 – 11:40: QUESTION/ANSWER SESSION

11:40 am – 1:00 pm: BUFFET LUNCH

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1:00 – 1:50 pm: TISSUE TYPING AND PATHOLOGY

MODERATOR: Robert Colvin

1:00 – 1:20: Peter Nickerson – HLA Molecular Mismatch a Prognostic Predictive Biomarker of Primary Alloimmunity

1:20 – 1:25: QUESTION/ANSWER SESSION

1:25 – 1:45: Jake Demetris – Importance of Tissue Pathology in Tolerance Trials 1:45 – 1:50 : QUESTION/ANSWER SESSION

1:50 – 2:55 pm: Summary & Panel Discussion

3:00 pm: Adjourn

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Speakers

Nancy Bridges National Institutes of Health Nancy.bridges@nih.gov

Sindhu Chandran University of California, San Francisco Sindhu.Chandran@ucsf.edu

Jake Demetris University of Pittsburgh demetrisaj@upmc.edu

Sandy Feng University of California, San Francisco sandy.feng@ucsf.edu

Ed Geissler University of Regensburg Edward.geissler@klinik.uni-regensburg.de

Ryoichi Goto University Hospital, Japan r-gotoh@mba.ocn.ne.jp

Abhi Humar University of Pittsburgh humara2@upmc.edu

Fadi Issa University of Oxford fadi.issa@nds.ox.ac.uk

Dixon Kaufman University of Wisconsin kaufman@surgery.wisc.edu

Tatsuo Kawai Massachusetts General Hospital Tkawai@mgh.harvard.edu

Kyowon Lee Samsung Medical Center kw1980.lee@gmail.com

Joe Leventhal Northwestern University jleventh@nm.org

Josh Levitsky Northwestern University j-levitsky@northwestern.edu

Ling Lu Nanjing Medical University lvling@njmu.edu.cn

Joren Madsen Harvard University jcmadsen@partners.org

Valeria Mas University of Tennessee vmas@uthsc.edu

Everett Meyer Stanford University evmeyer@stanford.edu

Peter Nickerson University of Manitoba peter.nickerson@umanitoba.ca

Alberto Sanchez-Fueyo King’s College London Sanchez_fueyo@kci.ac.uk

Birgit Sawitzki Charité University Hospital, Berlin Birgit.sawitzki@charite.de

Warren Shlomchik University of Pittsburgh warrens@pitt.edu

Samuel Strober Stanford University sstrober@stanford.edu

Megan Sykes Columbia University ms3976@cumc.columbia.edu

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Speakers Continued

Paul Szabolcs University of Pittsburgh szabolcsp@upmc.edu

Angus Thomson University of Pittsburgh thomsonaw@upmc.edu

Satoru Todo s-todo@st-mary-med-or.jp

Liz Welniak National Institutes of Health lis.welniak@nih.gov

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The University Club is just a short walk down Fifth Avenue from The Oaklander Hotel, or a scenic route in front of Soldiers & Sailors Memorial Hall.

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Speaker & Guest Reimbursement Information

We thank you for coming to Pittsburgh to attend and participate in the 4th International Workshop on Clinical Tolerance. We hope you found the meeting informative!

To ensure accurate and timely reimbursement, please review/complete the following:

For our International guests, please complete the attached W-8. o Scan/email the following to: Kristie Bowman, BOWMANKL2@UPMC.EDU

Completed W-8 Legible ground transportation receipts Airfare receipt (must contain the form of payment, with at least the last 4-digits of the credit

card number used to purchase the ticket)

For our Domestic guests, please complete the attached W-9. o Scan/email the following to: Kristie Bowman, BOWMANKL2@UPMC.EDU

Completed W-8 Legible ground transportation receipts Airfare receipt (must contain the form of payment, with at least the last 4-digits of the credit

card number used to purchase the ticket)

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W-8 Form

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W-9 Form

4th International Workshop on Clinical Tolerance

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