Post on 27-Jan-2020
NEW DIMENSION ! NOVEL INSIGHTS
IMMUNOTHERAPY Assessing tumor immune
response with AIM chips ex vivo ORGANOTYPIC TUMOR MODELS FOR IMMUNE BLOCKADE STUDIES 1
1. Jenkins, RW., et al., Ex vivo profiling of PD-1 blockade using organotypic tumor spheroids. Cancer Discov 2018; 8(2): 196-215.
3 POWERFUL TOOL FOR DRUG DISCOVERY
MDOTS cultured in AIM chips predict the effectiveness of novel combination therapies (PD-L1 blockade + TBK1 inhibitor), as
evidenced by in vivo tests using CT26 mice
Cmpd 1 : TBK1 Inhibitor
PRESERVES IMMUNE CELLS & TUMOR MICROENVIRONMENT
RECAPITULATES THE IN VIVO IMMUNE RESPONSE
SPEEDS UP DRUG DISCOVERY & DIAGNOSTICS
Workflow to develop murine-derived /patient-derived organotypic tumor spheroids (MDOTS/PDOTS) in AIM chips
VALIDATED AGAINST ANIMAL MODELS
MDOTS cultured in AIM chips capture the in vivo responses of PD-1 sensitive MC38 and PD-1 resistant
B16F10 under PD-1 treatment
PD-1 Sensitive PD-1 Resistant
2
Tumor Biopsies
AIM 3D Cell Culture Chips
PD -1 Blockade
• Dissociation • Size Selection • Immunophenotyping
Downstream Analysis • Live Cell Imaging • Immunofluorescence • Proteomic Profiling • Genomic Profiling • Flow Cytometry
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