The College of Judea and Samaria.Dept of Chemical Engineering and Biotechnology

: 778693630 436554430

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1 . , . ' . . ' . ' : , - .

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2 . in vitro .in vivo , . . , , , . , , . , . . , , (~ )0.1m, , .

3 2 3 3 4 5 1 2 3 4 5

1.5 ....................................................................................................5 1.1.5 -5...............................................................ECM 2.1.5 ...........................................................................6 3.1.5 -..............................................................................8 2.5 .............................................................................................................9 1.2.5 : .......................01

4 2.2.5 : .....................01 3.2.5 - ..............................11 4.2.5 ......................................................31 3.5 ...........................................................................................81 02 6

1.6 ..........................................................................................................02 1.1.6 .......................................................................................02 2.6 ..................................................................................................02 1.2.6 220............................................................................HepG 2.2.6 2-21...................................................................................C 3.2.6 ................................................................................................12 3.6 ...........................................................................................................22 1.3.6 .........................................................................................22 2.3.6 ............................................................................................32 3.3.6 - .........................................................................32 42 7

1.7 ..................................................................................................42 2.7 ...........................................................................................................42 82 8

1.8 ..................................................................................................82 2.8 ...........................................................................................................82 92 9

4 7 1 - . 2 . ........................................8

5 3 - 9.............................S. epidermidis 01 4 - 2

5- ( ) ( ) 41 ()1991,.Chang et al 6- 14.....................................................................S. aureus 7- 16.................................................AA, DMEA 8- S. epidermidis 16.....................PS/BSM,Si/BSM,PMMA/BSM 9 - S. aureus ................................................................71 01 - U-....V 81 11- 224.......................................................................HepG 21- Acinetobacter baumannii 42 ...........52 31- E. coli 42 ..................................................62 41 - E. coli 84 .............................................62 51- E. coli 84 ................................................72 61- 84 ....................................72

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1.5

1.1.5 -ECM (, , ,DNA ). , . , , , , .

6 , ( ,)actin ( ,)myosin (,)actinin ( ,)tropomyosin , ( ,)cytoskeleton . (,)integrins . . , , (, ). ( )ECM ' . ECM , . ECM : (, ) . ECM : , , , .

2.1.5 .ECM, . , . , , , . : ( :)focal adhesion . 10-20nm . ( :)close contact 30-50nm . :)ECM )extracellular matrix contact ECM . >001 .nm

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1.

1 - .

)a )b )c . -MF, -M , -AP , -FN, -ECMC -ECM, C , -F .

8 ECM . -, : ( )nexsus, ; ( )desmosome , ; (-)hemidesmosome ;ECM - . . .

3.1.5 - , . , . , , , . , 2.

2 .

* , , , , .

9 , , , , , .

2.5 - ( )extracellular material 3.

3 - S. epidermidis

- . , , , exhaustion conditions , slime . slime . slime , , , , . , .

01

1.2.5 : . . , ( ,)Brownain motion , , , ( )chemotaxis ( )hepatotaxis . - - chemoattractants: ,, . - -. , . ( , > )50nm , . (